GCVR_SHIFL
ID GCVR_SHIFL Reviewed; 190 AA.
AC P0A9I4; O30979; P23483; P77652;
DT 19-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 2.
DT 25-MAY-2022, entry version 105.
DE RecName: Full=Glycine cleavage system transcriptional repressor;
DE AltName: Full=Gcv operon repressor;
GN Name=gcvR; OrderedLocusNames=SF2522, S2672;
OS Shigella flexneri.
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Shigella.
OX NCBI_TaxID=623;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=301 / Serotype 2a;
RX PubMed=12384590; DOI=10.1093/nar/gkf566;
RA Jin Q., Yuan Z., Xu J., Wang Y., Shen Y., Lu W., Wang J., Liu H., Yang J.,
RA Yang F., Zhang X., Zhang J., Yang G., Wu H., Qu D., Dong J., Sun L.,
RA Xue Y., Zhao A., Gao Y., Zhu J., Kan B., Ding K., Chen S., Cheng H.,
RA Yao Z., He B., Chen R., Ma D., Qiang B., Wen Y., Hou Y., Yu J.;
RT "Genome sequence of Shigella flexneri 2a: insights into pathogenicity
RT through comparison with genomes of Escherichia coli K12 and O157.";
RL Nucleic Acids Res. 30:4432-4441(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700930 / 2457T / Serotype 2a;
RX PubMed=12704152; DOI=10.1128/iai.71.5.2775-2786.2003;
RA Wei J., Goldberg M.B., Burland V., Venkatesan M.M., Deng W., Fournier G.,
RA Mayhew G.F., Plunkett G. III, Rose D.J., Darling A., Mau B., Perna N.T.,
RA Payne S.M., Runyen-Janecky L.J., Zhou S., Schwartz D.C., Blattner F.R.;
RT "Complete genome sequence and comparative genomics of Shigella flexneri
RT serotype 2a strain 2457T.";
RL Infect. Immun. 71:2775-2786(2003).
CC -!- FUNCTION: Possible negative transcriptional regulator of the glycine
CC cleavage system operon (GCV). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
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DR EMBL; AE005674; AAN44025.1; -; Genomic_DNA.
DR EMBL; AE014073; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; NP_708318.1; NC_004337.2.
DR RefSeq; WP_000176187.1; NZ_WPGW01000011.1.
DR AlphaFoldDB; P0A9I4; -.
DR SMR; P0A9I4; -.
DR STRING; 198214.SF2522; -.
DR EnsemblBacteria; AAN44025; AAN44025; SF2522.
DR GeneID; 1025873; -.
DR GeneID; 66673656; -.
DR KEGG; sfl:SF2522; -.
DR PATRIC; fig|198214.7.peg.3015; -.
DR HOGENOM; CLU_095322_0_0_6; -.
DR OMA; TGGTMLN; -.
DR OrthoDB; 1859752at2; -.
DR Proteomes; UP000001006; Chromosome.
DR Proteomes; UP000002673; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR InterPro; IPR045865; ACT-like_dom_sf.
DR InterPro; IPR002912; ACT_dom.
DR InterPro; IPR016867; GcvR.
DR Pfam; PF01842; ACT; 1.
DR PIRSF; PIRSF028103; GcvR; 1.
DR SUPFAM; SSF55021; SSF55021; 2.
DR PROSITE; PS51671; ACT; 2.
PE 3: Inferred from homology;
KW Cytoplasm; Reference proteome; Repeat; Repressor; Transcription;
KW Transcription regulation.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000250"
FT CHAIN 2..190
FT /note="Glycine cleavage system transcriptional repressor"
FT /id="PRO_0000087449"
FT DOMAIN 10..91
FT /note="ACT 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01007"
FT DOMAIN 97..176
FT /note="ACT 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01007"
SQ SEQUENCE 190 AA; 20769 MW; 66A1998E767B556B CRC64;
MTLSSQHYLV ITALGADRPG IVNTITRHVS SCGCNIEDSR LAMLGEEFTF IMLLSGSWNA
ITLIESTLPL KGAELDLLIV MKRTTARPRP PMPASVWVQV DVADSPHLIE RFTALFDAHH
MNIAELVSRT QPAENERAAQ LHIQITAHSP ASADAANIEQ AFKALCTELN AQGSINVVNY
SQHDEQDGVK
