位置:首页 > 蛋白库 > GCYA2_RAT
GCYA2_RAT
ID   GCYA2_RAT               Reviewed;         730 AA.
AC   Q9WVI4; Q54A43;
DT   11-JUL-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 2.
DT   03-AUG-2022, entry version 151.
DE   RecName: Full=Guanylate cyclase soluble subunit alpha-2;
DE            Short=GCS-alpha-2;
DE            EC=4.6.1.2 {ECO:0000305|PubMed:11121588};
GN   Name=Gucy1a2;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], CATALYTIC ACTIVITY, ACTIVITY REGULATION, AND
RP   FUNCTION.
RC   STRAIN=Wistar Kyoto; TISSUE=Aorta;
RX   PubMed=11121588; DOI=10.1016/s0167-4781(00)00211-6;
RA   Koglin M., Behrends S.;
RT   "Cloning and functional expression of the rat alpha(2) subunit of soluble
RT   guanylyl cyclase.";
RL   Biochim. Biophys. Acta 1494:286-289(2000).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Yao Y., Yamamoto T., Suzuki N.;
RT   "Rat soluble guanylate cyclase alpha 2 subunit.";
RL   Submitted (NOV-2002) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Has guanylyl cyclase on binding to the beta-1 subunit.
CC       {ECO:0000305|PubMed:11121588}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=GTP = 3',5'-cyclic GMP + diphosphate; Xref=Rhea:RHEA:13665,
CC         ChEBI:CHEBI:33019, ChEBI:CHEBI:37565, ChEBI:CHEBI:57746; EC=4.6.1.2;
CC         Evidence={ECO:0000305|PubMed:11121588};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:13666;
CC         Evidence={ECO:0000305|PubMed:11121588};
CC   -!- ACTIVITY REGULATION: Activated by nitric oxide in the presence of
CC       magnesium or manganese ions. {ECO:0000250,
CC       ECO:0000269|PubMed:11121588}.
CC   -!- SUBUNIT: Heterodimer of an alpha and a beta chain. {ECO:0000250}.
CC   -!- INTERACTION:
CC       Q9WVI4; P31016: Dlg4; NbExp=7; IntAct=EBI-7665590, EBI-375655;
CC       Q9WVI4; Q62108: Dlg4; Xeno; NbExp=3; IntAct=EBI-7665590, EBI-300895;
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- MISCELLANEOUS: There are two types of guanylate cyclases: soluble forms
CC       and membrane-associated receptor forms.
CC   -!- SIMILARITY: Belongs to the adenylyl cyclase class-4/guanylyl cyclase
CC       family. {ECO:0000255|PROSITE-ProRule:PRU00099}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AF109963; AAD42949.2; -; mRNA.
DR   EMBL; AB096080; BAC24017.1; -; mRNA.
DR   RefSeq; NP_076446.1; NM_023956.1.
DR   AlphaFoldDB; Q9WVI4; -.
DR   SMR; Q9WVI4; -.
DR   IntAct; Q9WVI4; 5.
DR   MINT; Q9WVI4; -.
DR   STRING; 10116.ENSRNOP00000040361; -.
DR   iPTMnet; Q9WVI4; -.
DR   PhosphoSitePlus; Q9WVI4; -.
DR   PaxDb; Q9WVI4; -.
DR   PRIDE; Q9WVI4; -.
DR   DNASU; 66012; -.
DR   GeneID; 66012; -.
DR   KEGG; rno:66012; -.
DR   UCSC; RGD:621655; rat.
DR   CTD; 2977; -.
DR   RGD; 621655; Gucy1a2.
DR   VEuPathDB; HostDB:ENSRNOG00000029876; -.
DR   eggNOG; KOG4171; Eukaryota.
DR   HOGENOM; CLU_011614_5_0_1; -.
DR   InParanoid; Q9WVI4; -.
DR   OMA; SLMLHYF; -.
DR   OrthoDB; 531253at2759; -.
DR   PhylomeDB; Q9WVI4; -.
DR   PRO; PR:Q9WVI4; -.
DR   Proteomes; UP000002494; Chromosome 8.
DR   Bgee; ENSRNOG00000029876; Expressed in testis and 15 other tissues.
DR   Genevisible; Q9WVI4; RN.
DR   GO; GO:0005829; C:cytosol; TAS:Reactome.
DR   GO; GO:0008074; C:guanylate cyclase complex, soluble; IBA:GO_Central.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004383; F:guanylate cyclase activity; IDA:RGD.
DR   GO; GO:0020037; F:heme binding; IEA:InterPro.
DR   GO; GO:0044877; F:protein-containing complex binding; IPI:RGD.
DR   GO; GO:0019934; P:cGMP-mediated signaling; IBA:GO_Central.
DR   GO; GO:0007263; P:nitric oxide mediated signal transduction; IEA:Ensembl.
DR   GO; GO:0010750; P:positive regulation of nitric oxide mediated signal transduction; ISO:RGD.
DR   GO; GO:0070482; P:response to oxygen levels; IBA:GO_Central.
DR   CDD; cd07302; CHD; 1.
DR   Gene3D; 3.30.450.260; -; 1.
DR   Gene3D; 3.30.70.1230; -; 1.
DR   Gene3D; 3.90.1520.10; -; 1.
DR   InterPro; IPR001054; A/G_cyclase.
DR   InterPro; IPR018297; A/G_cyclase_CS.
DR   InterPro; IPR038158; H-NOX_domain_sf.
DR   InterPro; IPR011644; Heme_NO-bd.
DR   InterPro; IPR011645; HNOB_dom_associated.
DR   InterPro; IPR042463; HNOB_dom_associated_sf.
DR   InterPro; IPR024096; NO_sig/Golgi_transp_ligand-bd.
DR   InterPro; IPR029787; Nucleotide_cyclase.
DR   Pfam; PF00211; Guanylate_cyc; 1.
DR   Pfam; PF07700; HNOB; 1.
DR   Pfam; PF07701; HNOBA; 1.
DR   SMART; SM00044; CYCc; 1.
DR   SUPFAM; SSF111126; SSF111126; 1.
DR   SUPFAM; SSF55073; SSF55073; 1.
DR   PROSITE; PS00452; GUANYLATE_CYCLASE_1; 1.
DR   PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
PE   1: Evidence at protein level;
KW   cGMP biosynthesis; Cytoplasm; GTP-binding; Lyase; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..730
FT                   /note="Guanylate cyclase soluble subunit alpha-2"
FT                   /id="PRO_0000074114"
FT   DOMAIN          519..646
FT                   /note="Guanylate cyclase"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00099"
FT   REGION          1..53
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..19
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   730 AA;  81787 MW;  B8D790BFF81FB8F9 CRC64;
     MSRRKISSES FSSLGSDYLE TSPEEEGECP LSKLCWNGSR SPPGPPGSRA AAMAATPVPA
     ASVAAAAAAV AAGSKRAQRR RRVNLDSLGE SISLLTAPSP QTIHMTLKRT LQYYEHQVIG
     YRDAEKNFHN ISNRCSSADH SNKEEIEDVS GILRCTANVL GLKFQEIQER FGEEFFKICF
     DENERVLRAV GSTLQDFFNG FDALLEHIRT SFGKQATLES PSFLCKELPE GTLKLHYFHP
     HHTVGFAMLG MIKAAGKRIY HLNVEVEQIE NEKFCSDGST PSNYSCLTFL IKECETTQIT
     KNIPQGTSQI PTDLRISINT FCRTFPFHLM FDPNMVVLQL GEGLRKQLRC DNHKVLKFED
     CFEIVSPKVN ATFDRVLLRL STPFVIRTKP EASGTDNEDK VMEIKGQMIH VPESNAILFL
     GSPCVDKLDE LIGRGLHLSD IPIHDATRDV ILVGEQAKAQ DGLKKRMDKL KATLEKTHQA
     LEEEKKKTVD LLYSIFPGDV AQQLWQRQQV QARKFDDVTM LFSDIVGFTA ICAQCTPMQV
     ISMLNELYTR FDHQCGFLDI YKVETIGDAY CVASGLHRKS LCHAKPIALM ALKMMELSEE
     VLTPDGRPIQ MRIGIHSGSV LAGVVGVRMP RYCLFGNNVT LASKFESGSH PRRINISPTT
     YQLLKREDSF TFIPRSREEL PDNFPKEIPG VCYFLELRTG PKPPKPSLSS SRIKKVSYNI
     GTMFLRETSL
 
 
维奥蛋白资源库 - 中文蛋白资源 CopyRight © 2010-2024