GCY_ARBPU
ID GCY_ARBPU Reviewed; 986 AA.
AC P11528;
DT 01-OCT-1989, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1989, sequence version 1.
DT 03-AUG-2022, entry version 106.
DE RecName: Full=Resact receptor;
DE EC=4.6.1.2;
DE AltName: Full=Guanylate cyclase;
DE Flags: Precursor;
OS Arbacia punctulata (Punctuate sea urchin).
OC Eukaryota; Metazoa; Echinodermata; Eleutherozoa; Echinozoa; Echinoidea;
OC Euechinoidea; Echinacea; Arbacioida; Arbaciidae; Arbacia.
OX NCBI_TaxID=7641;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND PARTIAL PROTEIN SEQUENCE.
RC TISSUE=Testis;
RX PubMed=2901039; DOI=10.1038/334708a0;
RA Singh S., Lowe D.G., Thorpe D.S., Rodriguez H., Kuang W.-J., Dangott L.J.,
RA Chinkers M., Goeddel D.V., Garbers D.L.;
RT "Membrane guanylate cyclase is a cell-surface receptor with homology to
RT protein kinases.";
RL Nature 334:708-712(1988).
CC -!- FUNCTION: Implicated as a cell-surface receptor on spermatozoa for
CC 'resact' a chemotactic peptide, and on various other cells as a
CC receptor for atrial natriuretic peptide.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=GTP = 3',5'-cyclic GMP + diphosphate; Xref=Rhea:RHEA:13665,
CC ChEBI:CHEBI:33019, ChEBI:CHEBI:37565, ChEBI:CHEBI:57746; EC=4.6.1.2;
CC -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
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DR EMBL; X12874; CAA31367.1; -; mRNA.
DR PIR; S05480; OYURGA.
DR AlphaFoldDB; P11528; -.
DR SMR; P11528; -.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0004383; F:guanylate cyclase activity; IEA:UniProtKB-EC.
DR GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR GO; GO:0006468; P:protein phosphorylation; IEA:InterPro.
DR Gene3D; 3.30.70.1230; -; 1.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR011645; HNOB_dom_associated.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR029787; Nucleotide_cyclase.
DR InterPro; IPR028082; Peripla_BP_I.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR Pfam; PF01094; ANF_receptor; 1.
DR Pfam; PF07701; HNOBA; 1.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR SUPFAM; SSF53822; SSF53822; 1.
DR SUPFAM; SSF56112; SSF56112; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PE 1: Evidence at protein level;
KW cGMP biosynthesis; Direct protein sequencing; Glycoprotein; GTP-binding;
KW Lyase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Signal;
KW Transmembrane; Transmembrane helix.
FT SIGNAL 1..21
FT CHAIN 22..986
FT /note="Resact receptor"
FT /id="PRO_0000012389"
FT TOPO_DOM 22..507
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 508..528
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 529..986
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 568..836
FT /note="Protein kinase"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
FT CARBOHYD 185
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 361
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 410
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 986 AA; 111284 MW; B40238A74CCAFC52 CRC64;
MATTRLLFLL VVAVMITMVR SATLHYNPTV INLDRGRPKL HIGMLTSWTN ADNSQGTGFP
SAGAFPLAIQ YANNDMDILH GYDINFEWVD THCDINLGMA AISDWWKRGF LGVIGPGCGC
TYEGRLASAL NFPMIDYACD ENPVSNKEFY PTFLRTIPPS IQVVDSILLT LDMYDWNQVT
VVVENITKYR NVFNTMKEQF DMREEWEILH EEYYAGFDPW DPDAAEPFTD IIQRTKKTTR
IYVFFGDSGD LRQFAISALD VGILNSGDYA IVGAVIDLEI RDSQDYHSLE YTLEASDYLE
QINQAYEQMF KLREYTRTDD ERALEAMKSV LIVTGEPVLR SQAWHIYSAI VIDNALDEPF
NGTLELKTDI DMASVYIFDA TTELLKALDA TLQAGGDMYD GSQVVSNLFN TSYRSKAKAD
YQFDENGDGV KSYVLLHRIP IPVGDGGMPP GSPGMYPIGT FVRAESGHWS FNKDPDLNPV
WHNRDDPPLD MPVCGFHGEL CTNWGLYLGT LIPAFIIIFG GGLGYYIYRK RAYEAALDSL
VWKVDWKEVQ TRESETNSQG FSMKSMVLSA ISVISNAEKQ QIFATIGTYR GTICAIHAVH
KNHIDLTRAV RTELKLMRDM RHDNICPFIG ACIDRPHICI LMHYCAKGSL QDIMENDDIK
LDSMFLASLI ADLVKGLVYL HSSEIKSHGH LKSSNCVVDN RWVLQITDYG LHEFRKGQKE
DVDLGEHAKL ARKLWTAPEH LREGKSMHPG GTPKGDIYSF SIILTEMYSR QEPFHENDLE
LADIIARVSK GEVPPYRPVL NAVNEAAPDC VLTAIRACWV EDPMERPNII EVRTMLAPLQ
KGLKPNILDN MIAIMERYTN NLEELVDERT QELQKEKAKT EQLLHRMLPP SIASQLIKGI
SVLPETFDMV SIFFSDIVGF LIHFSLSSCR LFCSSQVLPL LVPWLHSLLT LPLHLPLIWM
NPLISSFAQP SWSALHSHSC SALHSS