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GCY_ARBPU
ID   GCY_ARBPU               Reviewed;         986 AA.
AC   P11528;
DT   01-OCT-1989, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1989, sequence version 1.
DT   03-AUG-2022, entry version 106.
DE   RecName: Full=Resact receptor;
DE            EC=4.6.1.2;
DE   AltName: Full=Guanylate cyclase;
DE   Flags: Precursor;
OS   Arbacia punctulata (Punctuate sea urchin).
OC   Eukaryota; Metazoa; Echinodermata; Eleutherozoa; Echinozoa; Echinoidea;
OC   Euechinoidea; Echinacea; Arbacioida; Arbaciidae; Arbacia.
OX   NCBI_TaxID=7641;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND PARTIAL PROTEIN SEQUENCE.
RC   TISSUE=Testis;
RX   PubMed=2901039; DOI=10.1038/334708a0;
RA   Singh S., Lowe D.G., Thorpe D.S., Rodriguez H., Kuang W.-J., Dangott L.J.,
RA   Chinkers M., Goeddel D.V., Garbers D.L.;
RT   "Membrane guanylate cyclase is a cell-surface receptor with homology to
RT   protein kinases.";
RL   Nature 334:708-712(1988).
CC   -!- FUNCTION: Implicated as a cell-surface receptor on spermatozoa for
CC       'resact' a chemotactic peptide, and on various other cells as a
CC       receptor for atrial natriuretic peptide.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=GTP = 3',5'-cyclic GMP + diphosphate; Xref=Rhea:RHEA:13665,
CC         ChEBI:CHEBI:33019, ChEBI:CHEBI:37565, ChEBI:CHEBI:57746; EC=4.6.1.2;
CC   -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
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DR   EMBL; X12874; CAA31367.1; -; mRNA.
DR   PIR; S05480; OYURGA.
DR   AlphaFoldDB; P11528; -.
DR   SMR; P11528; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004383; F:guanylate cyclase activity; IEA:UniProtKB-EC.
DR   GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR   GO; GO:0006468; P:protein phosphorylation; IEA:InterPro.
DR   Gene3D; 3.30.70.1230; -; 1.
DR   InterPro; IPR001828; ANF_lig-bd_rcpt.
DR   InterPro; IPR011645; HNOB_dom_associated.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR029787; Nucleotide_cyclase.
DR   InterPro; IPR028082; Peripla_BP_I.
DR   InterPro; IPR000719; Prot_kinase_dom.
DR   InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR   Pfam; PF01094; ANF_receptor; 1.
DR   Pfam; PF07701; HNOBA; 1.
DR   Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR   SUPFAM; SSF53822; SSF53822; 1.
DR   SUPFAM; SSF56112; SSF56112; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PE   1: Evidence at protein level;
KW   cGMP biosynthesis; Direct protein sequencing; Glycoprotein; GTP-binding;
KW   Lyase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Signal;
KW   Transmembrane; Transmembrane helix.
FT   SIGNAL          1..21
FT   CHAIN           22..986
FT                   /note="Resact receptor"
FT                   /id="PRO_0000012389"
FT   TOPO_DOM        22..507
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        508..528
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        529..986
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          568..836
FT                   /note="Protein kinase"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
FT   CARBOHYD        185
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        361
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        410
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   986 AA;  111284 MW;  B40238A74CCAFC52 CRC64;
     MATTRLLFLL VVAVMITMVR SATLHYNPTV INLDRGRPKL HIGMLTSWTN ADNSQGTGFP
     SAGAFPLAIQ YANNDMDILH GYDINFEWVD THCDINLGMA AISDWWKRGF LGVIGPGCGC
     TYEGRLASAL NFPMIDYACD ENPVSNKEFY PTFLRTIPPS IQVVDSILLT LDMYDWNQVT
     VVVENITKYR NVFNTMKEQF DMREEWEILH EEYYAGFDPW DPDAAEPFTD IIQRTKKTTR
     IYVFFGDSGD LRQFAISALD VGILNSGDYA IVGAVIDLEI RDSQDYHSLE YTLEASDYLE
     QINQAYEQMF KLREYTRTDD ERALEAMKSV LIVTGEPVLR SQAWHIYSAI VIDNALDEPF
     NGTLELKTDI DMASVYIFDA TTELLKALDA TLQAGGDMYD GSQVVSNLFN TSYRSKAKAD
     YQFDENGDGV KSYVLLHRIP IPVGDGGMPP GSPGMYPIGT FVRAESGHWS FNKDPDLNPV
     WHNRDDPPLD MPVCGFHGEL CTNWGLYLGT LIPAFIIIFG GGLGYYIYRK RAYEAALDSL
     VWKVDWKEVQ TRESETNSQG FSMKSMVLSA ISVISNAEKQ QIFATIGTYR GTICAIHAVH
     KNHIDLTRAV RTELKLMRDM RHDNICPFIG ACIDRPHICI LMHYCAKGSL QDIMENDDIK
     LDSMFLASLI ADLVKGLVYL HSSEIKSHGH LKSSNCVVDN RWVLQITDYG LHEFRKGQKE
     DVDLGEHAKL ARKLWTAPEH LREGKSMHPG GTPKGDIYSF SIILTEMYSR QEPFHENDLE
     LADIIARVSK GEVPPYRPVL NAVNEAAPDC VLTAIRACWV EDPMERPNII EVRTMLAPLQ
     KGLKPNILDN MIAIMERYTN NLEELVDERT QELQKEKAKT EQLLHRMLPP SIASQLIKGI
     SVLPETFDMV SIFFSDIVGF LIHFSLSSCR LFCSSQVLPL LVPWLHSLLT LPLHLPLIWM
     NPLISSFAQP SWSALHSHSC SALHSS
 
 
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