ID   GC_GAHVG                Reviewed;         505 AA.
AC   P10681;
DT   01-JAN-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1990, sequence version 1.
DT   29-SEP-2021, entry version 99.
DE   RecName: Full=Envelope glycoprotein C homolog;
DE   AltName: Full=A antigen;
DE   AltName: Full=Glycoprotein A;
DE            Short=GA;
DE   AltName: Full=Secretory glycoprotein GP57-65;
DE   Flags: Precursor;
GN   Name=gC; ORFNames=GA;
OS   Gallid herpesvirus 2 (strain GA) (GaHV-2) (Marek's disease herpesvirus type
OS   1).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Alphaherpesvirinae; Mardivirus.
OX   NCBI_TaxID=10388;
OH   NCBI_TaxID=9031; Gallus gallus (Chicken).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=2836620; DOI=10.1128/jvi.62.7.2373-2379.1988;
RA   Coussens P.M., Velicer L.F.;
RT   "Structure and complete nucleotide sequence of the Marek's disease
RT   herpesvirus gp57-65 gene.";
RL   J. Virol. 62:2373-2379(1988).
CC   -!- FUNCTION: May play an immunoevasive role in the pathogenesis of Marek's
CC       disease. It is a candidate for causing the early-stage
CC       immunosuppression that occurs after MDHV infection.
CC   -!- SUBCELLULAR LOCATION: Secreted. Host cell membrane; Single-pass
CC       membrane protein. Note=Predominantly secreted. Secreted, but a small
CC       amount of mature GP57-65 is anchored in the plasma membrane or held by
CC       other interactions.
CC   -!- SIMILARITY: Belongs to the herpesviridae glycoprotein C family.
CC       {ECO:0000305}.
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DR   EMBL; M20001; AAA46114.1; -; Genomic_DNA.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR001038; GA_GC.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR001654; Marek_A.
DR   Pfam; PF02124; Marek_A; 1.
DR   PRINTS; PR00675; MAREKSGPA.
DR   SUPFAM; SSF48726; SSF48726; 1.
DR   PROSITE; PS50835; IG_LIKE; 1.
PE   3: Inferred from homology;
KW   Glycoprotein; Host cell membrane; Host membrane; Host-virus interaction;
KW   Immunoglobulin domain; Membrane; Secreted; Signal; Transmembrane;
KW   Transmembrane helix.
FT   SIGNAL          1..27
FT                   /evidence="ECO:0000255"
FT   CHAIN           28..505
FT                   /note="Envelope glycoprotein C homolog"
FT                   /id="PRO_0000038208"
FT   TOPO_DOM        28..464
FT                   /note="Virion surface"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        465..491
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        492..505
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          257..355
FT                   /note="Ig-like"
FT   REGION          51..85
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        59..85
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        45
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        90
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        99
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        119
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        211
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        353
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        399
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        428
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   505 AA;  56809 MW;  D06D75D7D9C6666D CRC64;
     MLTPRVLRAL GWTGLFFLLL SPSNVLGASL SRDLEHPILS FDPSNISING APLTEVPHAP
     STESVSTNSE STNEHTITET TGKNAYIHNN ASTDKQNAND THKTPNILCD TEEVFVFLNE
     TGRFVCTLKV DPPSDSEWSN FVLDLIFNPI EYHANEKNVE AARIAGLYGV PGSDYAYPRQ
     SELISSIRRD PQGTFWTSPS PHGNKYFIWI NKTTNTMGVE IRNVDYADNG YMQVIMRDHF
     NRPLIDKHIY IRVCQRPASV DVLAPPVLSG ENYKASCIVR HFYPPGSVYV SWRQNGNIAT
     PRKDRDGSFW WFESGRGATL VSTITLGNSG IDFPPKISCL VAWKQGDMIS TTNATAIPTV
     YHHPRLSLAF KDGYAICTIE CVPSEITVRW LVHDEAQPNT TYNTVVTGLC RTIDRHRNLL
     SRIPVWDNWT KTKYTCRLIG YPFDEDKFQD SEYYDATPSA RGTPMVITVN GSFGIGCNFR
     VGDNHDCPMF IHSTRKIFDY NLIVM