ID   GC_GAHVR                Reviewed;         501 AA.
AC   P33500;
DT   01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1994, sequence version 1.
DT   29-SEP-2021, entry version 93.
DE   RecName: Full=Envelope glycoprotein C homolog;
DE   AltName: Full=A antigen;
DE   AltName: Full=Glycoprotein A;
DE            Short=GA;
DE   AltName: Full=Secretory glycoprotein GP57-65;
DE   Flags: Precursor;
GN   Name=gC; ORFNames=GA;
OS   Gallid herpesvirus 2 (strain RB-1b) (GaHV-2) (Marek's disease herpesvirus
OS   type 1).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Alphaherpesvirinae; Mardivirus.
OX   NCBI_TaxID=33707;
OH   NCBI_TaxID=9031; Gallus gallus (Chicken).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=2543160; DOI=10.1016/0168-1702(89)90094-4;
RA   Binns M.M., Ross N.L.J.;
RT   "Nucleotide sequence of the Marek's disease virus (MDV) RB-1B A antigen
RT   gene and the identification of the MDV A antigen as the herpes simplex
RT   virus-1 glycoprotein C homologue.";
RL   Virus Res. 12:371-382(1989).
CC   -!- FUNCTION: May play an immunoevasive role in the pathogenesis of Marek's
CC       disease. It is a candidate for causing the early-stage
CC       immunosuppression that occurs after MDHV infection.
CC   -!- SUBCELLULAR LOCATION: Secreted. Host cell membrane; Single-pass
CC       membrane protein. Note=Predominantly secreted. Secreted, but a small
CC       amount of mature GP57-65 is anchored in the plasma membrane or held by
CC       other interactions.
CC   -!- SIMILARITY: Belongs to the herpesviridae glycoprotein C family.
CC       {ECO:0000305}.
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DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR001038; GA_GC.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR001654; Marek_A.
DR   Pfam; PF02124; Marek_A; 1.
DR   PRINTS; PR00675; MAREKSGPA.
DR   SUPFAM; SSF48726; SSF48726; 1.
DR   PROSITE; PS50835; IG_LIKE; 1.
PE   3: Inferred from homology;
KW   Glycoprotein; Host cell membrane; Host membrane; Host-virus interaction;
KW   Immunoglobulin domain; Membrane; Secreted; Signal; Transmembrane;
KW   Transmembrane helix.
FT   SIGNAL          1..27
FT                   /evidence="ECO:0000255"
FT   CHAIN           28..501
FT                   /note="Envelope glycoprotein C homolog"
FT                   /id="PRO_0000038206"
FT   TOPO_DOM        28..465
FT                   /note="Virion surface"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        466..492
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        493..501
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          258..356
FT                   /note="Ig-like"
FT   REGION          53..86
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        60..86
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        46
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        91
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        100
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        120
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        212
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        354
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        400
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        429
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   501 AA;  56105 MW;  438473B1DD79340A CRC64;
     MLTPRVLRAL GWTGLFFLLL SPSNVLGASL SRDLETPPFL SFDPSNISIN GAPLTEVPHA
     PSTESVSTNS ESTNEHTITE TTGKNAYIHN NASTDKQNAN DTHKTPNILC DTEEVFVFLN
     ETGRFVCTLK VDPPSDSEWS NFVLDLIFNP IEYHANEKNV EAARIAGLYG VPGSDYAYPR
     QSELISSIRR DPQGTFWTSP SPHGNKYFIW INKTTNTMGV EIRNVDYADN GYMQVIMRDH
     FNRPLIDKHI YIRVCQRPAS VDVLAPPVLS GENYKASCIV RHFYPPGSVY VSWRQNGNIA
     TPRKDRDGSF WWFESGRGAT LVSTITLGNS GIDFPPKISC LVAWKQGDMI STTNATAIPT
     VYHHPRLSLA FKDGYAICTI ECVPSEITVR WLVHDEAQPN TTYNTVVTGL CRTIDRHRNL
     LSRIPVWDNW TKTKYTCRLI GYPFDEDKFQ DSEYYDATPS ARGTPMVITV TAVLGLAVIL
     GMGIIMTALC LYNSTRKNIR L