ID   GC_MEHVH                Reviewed;         489 AA.
AC   P18535;
DT   01-NOV-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1990, sequence version 1.
DT   29-SEP-2021, entry version 89.
DE   RecName: Full=Envelope glycoprotein C homolog;
DE   AltName: Full=A antigen;
DE   AltName: Full=Glycoprotein A;
DE   Flags: Precursor;
GN   Name=gC; ORFNames=GA;
OS   Meleagrid herpesvirus 1 (strain H2) (MeHV-1) (Turkey herpesvirus).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Alphaherpesvirinae; Mardivirus.
OX   NCBI_TaxID=10392;
OH   NCBI_TaxID=9031; Gallus gallus (Chicken).
OH   NCBI_TaxID=9103; Meleagris gallopavo (Wild turkey).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=2558972; DOI=10.1016/0378-1119(89)90514-3;
RA   Kato A., Sato I., Ihara T., Ueda S., Ishihama A., Hirai K.;
RT   "Homologies between herpesvirus of turkey and Marek's disease virus type-1
RT   DNAs within two co-linearly arranged open reading frames, one encoding
RT   glycoprotein A.";
RL   Gene 84:399-405(1989).
CC   -!- SUBCELLULAR LOCATION: Virion membrane {ECO:0000305}; Single-pass
CC       membrane protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the herpesviridae glycoprotein C family.
CC       {ECO:0000305}.
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DR   EMBL; M33303; AAA46107.1; -; Genomic_DNA.
DR   EMBL; D90003; BAA14056.1; -; Genomic_DNA.
DR   PIR; JQ0162; VGBETA.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell.
DR   Gene3D; 2.60.40.10; -; 1.
DR   InterPro; IPR001038; GA_GC.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR001654; Marek_A.
DR   Pfam; PF02124; Marek_A; 1.
DR   PRINTS; PR00675; MAREKSGPA.
DR   SUPFAM; SSF48726; SSF48726; 1.
DR   PROSITE; PS50835; IG_LIKE; 1.
PE   3: Inferred from homology;
KW   Glycoprotein; Host-virus interaction; Immunoglobulin domain; Membrane;
KW   Signal; Transmembrane; Transmembrane helix; Virion.
FT   SIGNAL          1..32
FT                   /evidence="ECO:0000255"
FT   CHAIN           33..489
FT                   /note="Envelope glycoprotein C homolog"
FT                   /id="PRO_0000038211"
FT   TOPO_DOM        33..455
FT                   /note="Virion surface"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        456..486
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        487..489
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          250..348
FT                   /note="Ig-like"
FT   REGION          59..94
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        59..91
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        92
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        112
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        204
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        346
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        392
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   489 AA;  54718 MW;  F4140C71342FCC5C CRC64;
     MVSNMRVLRV LRLTGWVGIF LVLSLQQTSC AGLPHNVDTH HILTFNPSPI SADGVPLSEV
     PNSPTTELST TVATKTAVPT TESTSSSEAH RNSSHKIPDI ICDREEVFVF LNNTGRILCD
     LIVDPPSDDE WSNFALDVTF NPIEYHANEK NVEVARVAGL YGVPGSDYAY PRKSELISSI
     RRDPQGSFWT SPTPRGNKYF IWINKTMHTM GVEVRNVDYK DNGYFQVILR DRFNRPLVEK
     HIYMRVCQRP ASVDVLAPPV LSGENYKASC IVRHFYPPGS VYVSWRRNGN IATPRKDRDG
     SFWWFESGRG ATLVSTITLG NSGLESPPKV SCLVAWRQGD MISTSNATAV PTVYYHPRIS
     LAFKDGYAIC TIECVPSGIT VRWLVHDEPQ PNTTYDTVVT GLCRTIDRYR NLASRIPVQD
     NWAKTKYTCR LIGYPFDVDR FQNSEYYDAT PSARGMPMIV TITAVLGLAL FLGIGIIITA
     LCFYLPGRN