GC_VZVD
ID GC_VZVD Reviewed; 591 AA.
AC P09256; P10241;
DT 01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
DT 24-MAR-2009, sequence version 2.
DT 02-JUN-2021, entry version 93.
DE RecName: Full=Envelope glycoprotein C;
DE Short=gC;
DE AltName: Full=Glycoprotein V;
DE Short=gpV;
GN Name=gC; ORFNames=14;
OS Varicella-zoster virus (strain Dumas) (HHV-3) (Human herpesvirus 3).
OC Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC Herpesvirales; Herpesviridae; Alphaherpesvirinae; Varicellovirus.
OX NCBI_TaxID=10338;
OH NCBI_TaxID=9606; Homo sapiens (Human).
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=3018124; DOI=10.1099/0022-1317-67-9-1759;
RA Davison A.J., Scott J.E.;
RT "The complete DNA sequence of varicella-zoster virus.";
RL J. Gen. Virol. 67:1759-1816(1986).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=Scott;
RX PubMed=3016329; DOI=10.1128/jvi.59.3.660-668.1986;
RA Kinchington P.R., Remenick J., Ostrove J.M., Straus S.E., Ruyechan W.T.,
RA Hay J.;
RT "Putative glycoprotein gene of varicella-zoster virus with variable copy
RT numbers of a 42-base-pair repeat sequence has homology to herpes simplex
RT virus glycoprotein C.";
RL J. Virol. 59:660-668(1986).
CC -!- FUNCTION: Essential for the initial attachment to heparan sulfate
CC moieties of the host cell surface proteoglycans. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Virion membrane {ECO:0000305}; Single-pass
CC membrane protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the herpesviridae glycoprotein C family.
CC {ECO:0000305}.
CC -!- CAUTION: It is uncertain whether Met-1 or Met-32 is the initiator.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAA27897.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; X04370; CAA27897.1; ALT_INIT; Genomic_DNA.
DR EMBL; M13795; AAA69563.1; -; Genomic_DNA.
DR PIR; E27342; VGBE14.
DR PRIDE; P09256; -.
DR Proteomes; UP000002602; Genome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0098671; P:adhesion receptor-mediated virion attachment to host cell; IEA:UniProtKB-KW.
DR GO; GO:0039573; P:suppression by virus of host complement activation; IEA:UniProtKB-KW.
DR GO; GO:0046718; P:viral entry into host cell; IEA:UniProtKB-KW.
DR Gene3D; 2.60.40.10; -; 1.
DR InterPro; IPR001038; GA_GC.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR Pfam; PF02124; Marek_A; 1.
DR PRINTS; PR00668; GLYCPROTEINC.
DR SUPFAM; SSF48726; SSF48726; 1.
PE 3: Inferred from homology;
KW Disulfide bond; Glycoprotein; Host-virus interaction;
KW Inhibition of host complement factors by virus; Membrane;
KW Reference proteome; Transmembrane; Transmembrane helix;
KW Viral attachment to host adhesion receptor; Viral attachment to host cell;
KW Viral immunoevasion; Virion; Virus entry into host cell.
FT CHAIN 1..591
FT /note="Envelope glycoprotein C"
FT /id="PRO_0000115762"
FT TOPO_DOM 1..561
FT /note="Virion surface"
FT /evidence="ECO:0000255"
FT TRANSMEM 562..582
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 583..591
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 70..179
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 237
FT /note="N-linked (GlcNAc...) asparagine; by host"
FT /evidence="ECO:0000255"
FT CARBOHYD 356
FT /note="N-linked (GlcNAc...) asparagine; by host"
FT /evidence="ECO:0000255"
FT CARBOHYD 375
FT /note="N-linked (GlcNAc...) asparagine; by host"
FT /evidence="ECO:0000255"
FT CARBOHYD 463
FT /note="N-linked (GlcNAc...) asparagine; by host"
FT /evidence="ECO:0000255"
FT DISULFID 189..207
FT /evidence="ECO:0000250"
FT DISULFID 374..436
FT /evidence="ECO:0000250"
FT DISULFID 475..533
FT /evidence="ECO:0000250"
FT DISULFID 479..507
FT /evidence="ECO:0000250"
FT VARIANT 26
FT /note="V -> G (in strain: Scott)"
FT VARIANT 96
FT /note="S -> T (in strain: Scott)"
FT VARIANT 124
FT /note="T -> S (in strain: Scott)"
FT VARIANT 138
FT /note="S -> T (in strain: Scott)"
FT VARIANT 154
FT /note="K -> N (in strain: Scott)"
FT VARIANT 166
FT /note="S -> T (in strain: Scott)"
FT VARIANT 175
FT /note="T -> A (in strain: Scott)"
FT VARIANT 184
FT /note="Y -> F (in strain: Scott)"
SQ SEQUENCE 591 AA; 64862 MW; A0104C906019D589 CRC64;
MSKKTFPSFK FRGGCFNLLF KGSVDVSIKT RMKRIQINLI LTIACIQLST ESQPTPVSIT
ELYTSAATRK PDPAVAPTSA ASRKPDPAVA PTSAASRKPD PAVAPTSAAS RKPDPAVAPT
SAATRKPDPA VAPTSAASRK PDPAVAPTSA ATRKPDPAVA PTSAASRKPD PAANTQHSQP
PFLYENIQCV HGGIQSIPYF HTFIMPCYMR LTTGQQAAFK QQQKTYEQYS LDPEGSNITR
WKSLIRPDLH IEVWFTRHLI DPHRQLGNAL IRMPDLPVML YSNSADLNLI NNPEIFTHAK
ENYVIPDVKT TSDFSVTILS MDATTEGTYI WRVVNTKTKN VISEHSITVT TYYRPNITVV
GDPVLTGQTY AAYCNVSKYY PPHSVRVRWT SRFGNIGKNF ITDAIQEYAN GLFSYVSAVR
IPQQKQMDYP PPAIQCNVLW IRDGVSNMKY SAVVTPDVYP FPNVSIGIID GHIVCTAKCV
PRGVVHFVWW VNDSPINHEN SEITGVCDQN KRFVNMQSSC PTSELDGPIT YSCHLDGYPK
KFPPFSAVYT YDASTYATTF SVVAVIIGVI SILGTLGLIA VIATLCIRCC S
