ID   GDA0_WHEAT              Reviewed;         286 AA.
AC   P02863;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   21-JUL-1986, sequence version 2.
DT   03-AUG-2022, entry version 104.
DE   RecName: Full=Alpha/beta-gliadin;
DE   AltName: Full=Prolamin;
DE   Flags: Precursor;
OS   Triticum aestivum (Wheat).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC   Pooideae; Triticodae; Triticeae; Triticinae; Triticum.
OX   NCBI_TaxID=4565;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=cv. Newton;
RX   PubMed=6204862; DOI=10.1002/j.1460-2075.1984.tb01985.x;
RA   Rafalski J.A., Scheets K., Metzler M., Peterson D.M., Hedgcoth C.,
RA   Soll D.G.;
RT   "Developmentally regulated plant genes: the nucleotide sequence of a wheat
RT   gliadin genomic clone.";
RL   EMBO J. 3:1409-1415(1984).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=3839304; DOI=10.1093/nar/13.11.3905;
RA   Sumner-Smith M., Rafalski J.A., Sugiyama T., Stoll M., Soell D.;
RT   "Conservation and variability of wheat alpha/beta-gliadin genes.";
RL   Nucleic Acids Res. 13:3905-3916(1985).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=6095191; DOI=10.1093/nar/12.21.8129;
RA   Anderson O.D., Litts J.C., Gautier M.-F., Greene F.C.;
RT   "Nucleic acid sequence and chromosome assignment of a wheat storage protein
RT   gene.";
RL   Nucleic Acids Res. 12:8129-8144(1984).
CC   -!- FUNCTION: Gliadin is the major seed storage protein in wheat.
CC   -!- PTM: Substrate of transglutaminase. {ECO:0000250}.
CC   -!- ALLERGEN: Causes an allergic reaction in human. Is the cause of the
CC       celiac disease, also known as celiac sprue or gluten-sensitive
CC       enteropathy (By similarity). {ECO:0000250}.
CC   -!- MISCELLANEOUS: The alpha/beta-gliadins can be divided into 5 homology
CC       classes. Sequence divergence between the classes is due to single base
CC       substitutions and to duplications or deletions within or near direct
CC       repeats. There are more than a 100 copies of the gene for alpha/beta-
CC       gliadin per haploid genome.
CC   -!- SIMILARITY: Belongs to the gliadin/glutenin family. {ECO:0000305}.
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DR   EMBL; K03076; AAA34280.1; -; mRNA.
DR   EMBL; X02539; CAA26384.1; -; Genomic_DNA.
DR   EMBL; X01130; CAA25593.1; -; Genomic_DNA.
DR   PIR; A03354; EEWTA.
DR   PIR; S07923; S07923.
DR   AlphaFoldDB; P02863; -.
DR   PRIDE; P02863; -.
DR   ABCD; P02863; 6 sequenced antibodies.
DR   Proteomes; UP000019116; Unplaced.
DR   ExpressionAtlas; P02863; baseline and differential.
DR   GO; GO:0045735; F:nutrient reservoir activity; IEA:UniProtKB-KW.
DR   CDD; cd00261; AAI_SS; 1.
DR   Gene3D; 1.10.110.10; -; 1.
DR   InterPro; IPR044723; AAI_SS_dom.
DR   InterPro; IPR036312; Bifun_inhib/LTP/seed_sf.
DR   InterPro; IPR016140; Bifunc_inhib/LTP/seed_store.
DR   InterPro; IPR001954; Glia_glutenin.
DR   PANTHER; PTHR33454; PTHR33454; 1.
DR   Pfam; PF00234; Tryp_alpha_amyl; 1.
DR   PRINTS; PR00208; GLIADGLUTEN.
DR   SMART; SM00499; AAI; 1.
DR   SUPFAM; SSF47699; SSF47699; 1.
PE   2: Evidence at transcript level;
KW   Allergen; Reference proteome; Repeat; Seed storage protein; Signal;
KW   Storage protein.
FT   SIGNAL          1..20
FT   CHAIN           21..286
FT                   /note="Alpha/beta-gliadin"
FT                   /id="PRO_0000032267"
FT   REGION          51..120
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        57..108
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        37
FT                   /note="Q -> L (in Ref. 1)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        93
FT                   /note="P -> Q (in Ref. 2; CAA26384)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        193..194
FT                   /note="HN -> LK (in Ref. 3; CAA25593)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   286 AA;  32963 MW;  E5EBD3BBE292E0C6 CRC64;
     MKTFLILVLL AIVATTATTA VRFPVPQLQP QNPSQQQPQE QVPLVQQQQF LGQQQPFPPQ
     QPYPQPQPFP SQLPYLQLQP FPQPQLPYSQ PQPFRPQQPY PQPQPQYSQP QQPISQQQQQ
     QQQQQQQQQQ QQQILQQILQ QQLIPCMDVV LQQHNIAHGR SQVLQQSTYQ LLQELCCQHL
     WQIPEQSQCQ AIHNVVHAII LHQQQKQQQQ PSSQVSFQQP LQQYPLGQGS FRPSQQNPQA
     QGSVQPQQLP QFEEIRNLAL QTLPAMCNVY IPPYCTIAPF GIFGTN