ID   GDA2_WHEAT              Reviewed;         291 AA.
AC   P04722;
DT   13-AUG-1987, integrated into UniProtKB/Swiss-Prot.
DT   13-AUG-1987, sequence version 1.
DT   03-AUG-2022, entry version 99.
DE   RecName: Full=Alpha/beta-gliadin A-II;
DE   AltName: Full=Prolamin;
DE   Flags: Precursor;
OS   Triticum aestivum (Wheat).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC   Pooideae; Triticodae; Triticeae; Triticinae; Triticum.
OX   NCBI_TaxID=4565;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=2989281; DOI=10.1016/s0021-9258(17)39582-0;
RA   Okita T.W., Cheesbrough V., Reeves C.D.;
RT   "Evolution and heterogeneity of the alpha-/beta-type and gamma-type gliadin
RT   DNA sequences.";
RL   J. Biol. Chem. 260:8203-8213(1985).
CC   -!- FUNCTION: Gliadin is the major seed storage protein in wheat.
CC   -!- PTM: Substrate of transglutaminase. {ECO:0000250}.
CC   -!- ALLERGEN: Causes an allergic reaction in human. Is the cause of the
CC       celiac disease, also known as celiac sprue or gluten-sensitive
CC       enteropathy (By similarity). {ECO:0000250}.
CC   -!- MISCELLANEOUS: The alpha/beta-gliadins can be divided into 5 homology
CC       classes. Sequence divergence between the classes is due to single base
CC       substitutions and to duplications or deletions within or near direct
CC       repeats. There are more than a 100 copies of the gene for alpha/beta-
CC       gliadin per haploid genome.
CC   -!- SIMILARITY: Belongs to the gliadin/glutenin family. {ECO:0000305}.
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DR   EMBL; M10092; AAA34276.1; -; mRNA.
DR   PIR; C22364; C22364.
DR   PIR; T06498; T06498.
DR   AlphaFoldDB; P04722; -.
DR   SMR; P04722; -.
DR   PRIDE; P04722; -.
DR   Proteomes; UP000019116; Unplaced.
DR   ExpressionAtlas; P04722; baseline and differential.
DR   GO; GO:0045735; F:nutrient reservoir activity; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.110.10; -; 1.
DR   InterPro; IPR036312; Bifun_inhib/LTP/seed_sf.
DR   InterPro; IPR016140; Bifunc_inhib/LTP/seed_store.
DR   InterPro; IPR001954; Glia_glutenin.
DR   PANTHER; PTHR33454; PTHR33454; 1.
DR   Pfam; PF00234; Tryp_alpha_amyl; 1.
DR   PRINTS; PR00208; GLIADGLUTEN.
DR   SMART; SM00499; AAI; 1.
DR   SUPFAM; SSF47699; SSF47699; 1.
PE   2: Evidence at transcript level;
KW   Allergen; Reference proteome; Repeat; Seed storage protein; Signal;
KW   Storage protein.
FT   SIGNAL          1..20
FT   CHAIN           21..291
FT                   /note="Alpha/beta-gliadin A-II"
FT                   /id="PRO_0000032269"
FT   REGION          32..120
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          227..250
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        32..56
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        57..108
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   291 AA;  33661 MW;  9B39F93B0825A2E0 CRC64;
     MKTFPILALL AIVATTATTA VRVPVPQLQL QNPSQQQPQE QVPLVQEQQF QGQQQPFPPQ
     QPYPQPQPFP SQQPYLQLQP FPQPQLPYPQ PQPFRPQQPY PQPQPQYSQP QQPISQQQQQ
     QQQQQQQQQQ ILQQILQQQL IPCRDVVLQQ HNIAHGSSQV LQESTYQLVQ QLCCQQLWQI
     PEQSRCQAIH NVVHAIILHQ QHHHHQQQQQ QQQQQPLSQV SFQQPQQQYP SGQGFFQPSQ
     QNPQAQGSFQ PQQLPQFEEI RNLALQTLPA MCNVYIPPYC TIAPFGIFGT N