GDA4_WHEAT
ID GDA4_WHEAT Reviewed; 297 AA.
AC P04724;
DT 13-AUG-1987, integrated into UniProtKB/Swiss-Prot.
DT 13-AUG-1987, sequence version 1.
DT 03-AUG-2022, entry version 96.
DE RecName: Full=Alpha/beta-gliadin A-IV;
DE AltName: Full=Prolamin;
DE Flags: Precursor;
OS Triticum aestivum (Wheat).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Pooideae; Triticodae; Triticeae; Triticinae; Triticum.
OX NCBI_TaxID=4565;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=2989281; DOI=10.1016/s0021-9258(17)39582-0;
RA Okita T.W., Cheesbrough V., Reeves C.D.;
RT "Evolution and heterogeneity of the alpha-/beta-type and gamma-type gliadin
RT DNA sequences.";
RL J. Biol. Chem. 260:8203-8213(1985).
CC -!- FUNCTION: Gliadin is the major seed storage protein in wheat.
CC -!- PTM: Substrate of transglutaminase. {ECO:0000250}.
CC -!- ALLERGEN: Causes an allergic reaction in human. Is the cause of the
CC celiac disease, also known as celiac sprue or gluten-sensitive
CC enteropathy (By similarity). {ECO:0000250}.
CC -!- MISCELLANEOUS: The alpha/beta-gliadins can be divided into 5 homology
CC classes. Sequence divergence between the classes is due to single base
CC substitutions and to duplications or deletions within or near direct
CC repeats. There are more than a 100 copies of the gene for alpha/beta-
CC gliadin per haploid genome.
CC -!- SIMILARITY: Belongs to the gliadin/glutenin family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; M11075; AAA34282.1; -; mRNA.
DR PIR; D22364; D22364.
DR PIR; T06500; T06500.
DR AlphaFoldDB; P04724; -.
DR PRIDE; P04724; -.
DR Proteomes; UP000019116; Unplaced.
DR ExpressionAtlas; P04724; baseline and differential.
DR GO; GO:0045735; F:nutrient reservoir activity; IEA:UniProtKB-KW.
DR CDD; cd00261; AAI_SS; 1.
DR Gene3D; 1.10.110.10; -; 1.
DR InterPro; IPR044723; AAI_SS_dom.
DR InterPro; IPR036312; Bifun_inhib/LTP/seed_sf.
DR InterPro; IPR016140; Bifunc_inhib/LTP/seed_store.
DR InterPro; IPR001954; Glia_glutenin.
DR PANTHER; PTHR33454; PTHR33454; 1.
DR Pfam; PF13016; Gliadin; 1.
DR PRINTS; PR00208; GLIADGLUTEN.
DR SMART; SM00499; AAI; 1.
DR SUPFAM; SSF47699; SSF47699; 1.
PE 2: Evidence at transcript level;
KW Allergen; Reference proteome; Repeat; Seed storage protein; Signal;
KW Storage protein.
FT SIGNAL 1..20
FT CHAIN 21..297
FT /note="Alpha/beta-gliadin A-IV"
FT /id="PRO_0000032271"
FT REGION 29..127
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 234..257
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 29..54
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 55..107
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 108..127
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 297 AA; 34239 MW; 0025ED289AE9588B CRC64;
MKTFLILALR AIVATTATIA VRVPVPQLQP QNPSQQQPQK QVPLVQQQQF PGQQQPFPPQ
QPYPQQQPFP SQQPYMQLQP FPQPQLPYPQ PQLPYPQPQP FRPQQSYPQP QPQYSQPQQP
ISQQQQQQQQ QQQQQQQILQ QILQQQLIPC RDVVLQQHSI AHGSSQVLQQ STYQLVQQFC
CQQLWQIPEQ SRCQAIHNVV HAIILHQQQQ QQQQQQQQQQ QPLSQVCFQQ SQQQYPSGQG
SFQPSQQNPQ AQGSVQPQQL PQFEEIRNLA LETLPAMCNV YIPPYCTIAP VGIFGTN