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GDA4_WHEAT
ID   GDA4_WHEAT              Reviewed;         297 AA.
AC   P04724;
DT   13-AUG-1987, integrated into UniProtKB/Swiss-Prot.
DT   13-AUG-1987, sequence version 1.
DT   03-AUG-2022, entry version 96.
DE   RecName: Full=Alpha/beta-gliadin A-IV;
DE   AltName: Full=Prolamin;
DE   Flags: Precursor;
OS   Triticum aestivum (Wheat).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC   Pooideae; Triticodae; Triticeae; Triticinae; Triticum.
OX   NCBI_TaxID=4565;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=2989281; DOI=10.1016/s0021-9258(17)39582-0;
RA   Okita T.W., Cheesbrough V., Reeves C.D.;
RT   "Evolution and heterogeneity of the alpha-/beta-type and gamma-type gliadin
RT   DNA sequences.";
RL   J. Biol. Chem. 260:8203-8213(1985).
CC   -!- FUNCTION: Gliadin is the major seed storage protein in wheat.
CC   -!- PTM: Substrate of transglutaminase. {ECO:0000250}.
CC   -!- ALLERGEN: Causes an allergic reaction in human. Is the cause of the
CC       celiac disease, also known as celiac sprue or gluten-sensitive
CC       enteropathy (By similarity). {ECO:0000250}.
CC   -!- MISCELLANEOUS: The alpha/beta-gliadins can be divided into 5 homology
CC       classes. Sequence divergence between the classes is due to single base
CC       substitutions and to duplications or deletions within or near direct
CC       repeats. There are more than a 100 copies of the gene for alpha/beta-
CC       gliadin per haploid genome.
CC   -!- SIMILARITY: Belongs to the gliadin/glutenin family. {ECO:0000305}.
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DR   EMBL; M11075; AAA34282.1; -; mRNA.
DR   PIR; D22364; D22364.
DR   PIR; T06500; T06500.
DR   AlphaFoldDB; P04724; -.
DR   PRIDE; P04724; -.
DR   Proteomes; UP000019116; Unplaced.
DR   ExpressionAtlas; P04724; baseline and differential.
DR   GO; GO:0045735; F:nutrient reservoir activity; IEA:UniProtKB-KW.
DR   CDD; cd00261; AAI_SS; 1.
DR   Gene3D; 1.10.110.10; -; 1.
DR   InterPro; IPR044723; AAI_SS_dom.
DR   InterPro; IPR036312; Bifun_inhib/LTP/seed_sf.
DR   InterPro; IPR016140; Bifunc_inhib/LTP/seed_store.
DR   InterPro; IPR001954; Glia_glutenin.
DR   PANTHER; PTHR33454; PTHR33454; 1.
DR   Pfam; PF13016; Gliadin; 1.
DR   PRINTS; PR00208; GLIADGLUTEN.
DR   SMART; SM00499; AAI; 1.
DR   SUPFAM; SSF47699; SSF47699; 1.
PE   2: Evidence at transcript level;
KW   Allergen; Reference proteome; Repeat; Seed storage protein; Signal;
KW   Storage protein.
FT   SIGNAL          1..20
FT   CHAIN           21..297
FT                   /note="Alpha/beta-gliadin A-IV"
FT                   /id="PRO_0000032271"
FT   REGION          29..127
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          234..257
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        29..54
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        55..107
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        108..127
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   297 AA;  34239 MW;  0025ED289AE9588B CRC64;
     MKTFLILALR AIVATTATIA VRVPVPQLQP QNPSQQQPQK QVPLVQQQQF PGQQQPFPPQ
     QPYPQQQPFP SQQPYMQLQP FPQPQLPYPQ PQLPYPQPQP FRPQQSYPQP QPQYSQPQQP
     ISQQQQQQQQ QQQQQQQILQ QILQQQLIPC RDVVLQQHSI AHGSSQVLQQ STYQLVQQFC
     CQQLWQIPEQ SRCQAIHNVV HAIILHQQQQ QQQQQQQQQQ QPLSQVCFQQ SQQQYPSGQG
     SFQPSQQNPQ AQGSVQPQQL PQFEEIRNLA LETLPAMCNV YIPPYCTIAP VGIFGTN
 
 
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