ID   GDA5_WHEAT              Reviewed;         319 AA.
AC   P04725;
DT   13-AUG-1987, integrated into UniProtKB/Swiss-Prot.
DT   13-AUG-1987, sequence version 1.
DT   03-AUG-2022, entry version 86.
DE   RecName: Full=Alpha/beta-gliadin A-V;
DE   AltName: Full=Prolamin;
DE   Flags: Precursor;
OS   Triticum aestivum (Wheat).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC   Pooideae; Triticodae; Triticeae; Triticinae; Triticum.
OX   NCBI_TaxID=4565;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=2989281; DOI=10.1016/s0021-9258(17)39582-0;
RA   Okita T.W., Cheesbrough V., Reeves C.D.;
RT   "Evolution and heterogeneity of the alpha-/beta-type and gamma-type gliadin
RT   DNA sequences.";
RL   J. Biol. Chem. 260:8203-8213(1985).
CC   -!- FUNCTION: Gliadin is the major seed storage protein in wheat.
CC   -!- PTM: Substrate of transglutaminase. {ECO:0000250}.
CC   -!- ALLERGEN: Causes an allergic reaction in human. Is the cause of the
CC       celiac disease, also known as celiac sprue or gluten-sensitive
CC       enteropathy (By similarity). {ECO:0000250}.
CC   -!- MISCELLANEOUS: The alpha/beta-gliadins can be divided into 5 homology
CC       classes. Sequence divergence between the classes is due to single base
CC       substitutions and to duplications or deletions within or near direct
CC       repeats. There are more than a 100 copies of the gene for alpha/beta-
CC       gliadin per haploid genome.
CC   -!- SIMILARITY: Belongs to the gliadin/glutenin family. {ECO:0000305}.
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DR   EMBL; M11073; AAA34278.1; -; mRNA.
DR   PIR; A22364; A22364.
DR   AlphaFoldDB; P04725; -.
DR   Proteomes; UP000019116; Unplaced.
DR   ExpressionAtlas; P04725; baseline and differential.
DR   GO; GO:0045735; F:nutrient reservoir activity; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.110.10; -; 1.
DR   InterPro; IPR036312; Bifun_inhib/LTP/seed_sf.
DR   InterPro; IPR016140; Bifunc_inhib/LTP/seed_store.
DR   InterPro; IPR001954; Glia_glutenin.
DR   PANTHER; PTHR33454; PTHR33454; 2.
DR   Pfam; PF00234; Tryp_alpha_amyl; 1.
DR   PRINTS; PR00208; GLIADGLUTEN.
DR   SMART; SM00499; AAI; 1.
DR   SUPFAM; SSF47699; SSF47699; 1.
PE   2: Evidence at transcript level;
KW   Allergen; Reference proteome; Repeat; Seed storage protein; Signal;
KW   Storage protein.
FT   SIGNAL          1..20
FT   CHAIN           21..319
FT                   /note="Alpha/beta-gliadin A-V"
FT                   /id="PRO_0000032272"
FT   REGION          28..125
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          258..278
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        28..56
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        57..108
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        109..125
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   319 AA;  36666 MW;  C98ACA5FF58905B7 CRC64;
     MKTFLILALL AIVATTATTA VRVPVPQLQP QNPSQQQPQE QVPLVQQQQF PGQQQQFPPQ
     QPYPQPQPFP SQQPYLQLQP FPQPQPFPPQ LPYPQPQSFP PQQPYPQQQP QYLQPQQPIS
     QQQAQQQQQQ QQQQQQQQQI LQQILQQQLI PCRDVVLQQH NIAHASSQVL QQSTYQLLQQ
     LCCQQLLQIP EQSQCQAIHN VAHAIIMHQQ QQQQQEQKQQ LQQQQQQQQQ LQQQQQQQQQ
     QPSSQVSFQQ PQQQYPSSQV SFQPSQLNPQ AQGSVQPQQL PQFAEIRNLA LQTLPAMCNV
     YIPPHCSTTI APFGISGTN