GDA6_WHEAT
ID GDA6_WHEAT Reviewed; 296 AA.
AC P04726;
DT 13-AUG-1987, integrated into UniProtKB/Swiss-Prot.
DT 13-AUG-1987, sequence version 1.
DT 03-AUG-2022, entry version 91.
DE RecName: Full=Alpha/beta-gliadin clone PW1215;
DE AltName: Full=Prolamin;
DE Flags: Precursor;
OS Triticum aestivum (Wheat).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Pooideae; Triticodae; Triticeae; Triticinae; Triticum.
OX NCBI_TaxID=4565;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=3839304; DOI=10.1093/nar/13.11.3905;
RA Sumner-Smith M., Rafalski J.A., Sugiyama T., Stoll M., Soell D.;
RT "Conservation and variability of wheat alpha/beta-gliadin genes.";
RL Nucleic Acids Res. 13:3905-3916(1985).
CC -!- FUNCTION: Gliadin is the major seed storage protein in wheat.
CC -!- PTM: Substrate of transglutaminase. {ECO:0000250}.
CC -!- ALLERGEN: Causes an allergic reaction in human. Is the cause of the
CC celiac disease, also known as celiac sprue or gluten-sensitive
CC enteropathy (By similarity). {ECO:0000250}.
CC -!- MISCELLANEOUS: The alpha/beta-gliadins can be divided into 5 homology
CC classes. Sequence divergence between the classes is due to single base
CC substitutions and to duplications or deletions within or near direct
CC repeats. There are more than a 100 copies of the gene for alpha/beta-
CC gliadin per haploid genome.
CC -!- SIMILARITY: Belongs to the gliadin/glutenin family. {ECO:0000305}.
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DR EMBL; X02538; CAA26383.1; -; Genomic_DNA.
DR EMBL; K03074; AAA34277.1; -; Genomic_DNA.
DR PIR; S07361; S07361.
DR AlphaFoldDB; P04726; -.
DR PRIDE; P04726; -.
DR EnsemblPlants; TraesCLE_scaffold_070025_01G000100.1; TraesCLE_scaffold_070025_01G000100.1; TraesCLE_scaffold_070025_01G000100.
DR EnsemblPlants; TraesROB_scaffold_071755_01G000100.1; TraesROB_scaffold_071755_01G000100.1; TraesROB_scaffold_071755_01G000100.
DR EnsemblPlants; TraesWEE_scaffold_105086_01G000100.1; TraesWEE_scaffold_105086_01G000100.1; TraesWEE_scaffold_105086_01G000100.
DR Gramene; TraesCLE_scaffold_070025_01G000100.1; TraesCLE_scaffold_070025_01G000100.1; TraesCLE_scaffold_070025_01G000100.
DR Gramene; TraesROB_scaffold_071755_01G000100.1; TraesROB_scaffold_071755_01G000100.1; TraesROB_scaffold_071755_01G000100.
DR Gramene; TraesWEE_scaffold_105086_01G000100.1; TraesWEE_scaffold_105086_01G000100.1; TraesWEE_scaffold_105086_01G000100.
DR Proteomes; UP000019116; Unplaced.
DR ExpressionAtlas; P04726; baseline and differential.
DR GO; GO:0045735; F:nutrient reservoir activity; IEA:UniProtKB-KW.
DR CDD; cd00261; AAI_SS; 1.
DR Gene3D; 1.10.110.10; -; 2.
DR InterPro; IPR044723; AAI_SS_dom.
DR InterPro; IPR036312; Bifun_inhib/LTP/seed_sf.
DR InterPro; IPR016140; Bifunc_inhib/LTP/seed_store.
DR InterPro; IPR001954; Glia_glutenin.
DR PANTHER; PTHR33454; PTHR33454; 2.
DR Pfam; PF00234; Tryp_alpha_amyl; 1.
DR PRINTS; PR00208; GLIADGLUTEN.
DR SMART; SM00499; AAI; 1.
DR SUPFAM; SSF47699; SSF47699; 1.
PE 3: Inferred from homology;
KW Allergen; Reference proteome; Repeat; Seed storage protein; Signal;
KW Storage protein.
FT SIGNAL 1..20
FT CHAIN 21..296
FT /note="Alpha/beta-gliadin clone PW1215"
FT /id="PRO_0000032273"
FT REGION 24..126
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 220..255
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 38..56
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 57..115
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 296 AA; 33941 MW; A9BDF590AD40F135 CRC64;
MKTFLILALL AIVATTATTA VRVPVPQPQP QNPSQPQPQG QVPLVQQQQF PGQQQQFPPQ
QPYPQPQPFP SQQPYLQLQP FPQPQPFPPQ LPYPQPPPFS PQQPYPQPQP QYPQPQQPIS
QQQAQQQQQQ QQQQQQQQQQ QQILQQILQQ QLIPCRDVVL QQHNIAHARS QVLQQSTYQP
LQQLCCQQLW QIPEQSRCQA IHNVVHAIIL HQQQRQQQPS SQVSLQQPQQ QYPSGQGFFQ
PSQQNPQAQG SVQPQQLPQF EEIRNLALQT LPRMCNVYIP PYCSTTIAPF GIFGTN
