ID   GDA7_WHEAT              Reviewed;         313 AA.
AC   P04727;
DT   13-AUG-1987, integrated into UniProtKB/Swiss-Prot.
DT   13-AUG-1987, sequence version 1.
DT   03-AUG-2022, entry version 85.
DE   RecName: Full=Alpha/beta-gliadin clone PW8142;
DE   AltName: Full=Prolamin;
DE   Flags: Precursor;
OS   Triticum aestivum (Wheat).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC   Pooideae; Triticodae; Triticeae; Triticinae; Triticum.
OX   NCBI_TaxID=4565;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=3839304; DOI=10.1093/nar/13.11.3905;
RA   Sumner-Smith M., Rafalski J.A., Sugiyama T., Stoll M., Soell D.;
RT   "Conservation and variability of wheat alpha/beta-gliadin genes.";
RL   Nucleic Acids Res. 13:3905-3916(1985).
CC   -!- FUNCTION: Gliadin is the major seed storage protein in wheat.
CC   -!- PTM: Substrate of transglutaminase. {ECO:0000250}.
CC   -!- ALLERGEN: Causes an allergic reaction in human. Is the cause of the
CC       celiac disease, also known as celiac sprue or gluten-sensitive
CC       enteropathy (By similarity). {ECO:0000250}.
CC   -!- MISCELLANEOUS: The alpha/beta-gliadins can be divided into 5 homology
CC       classes. Sequence divergence between the classes is due to single base
CC       substitutions and to duplications or deletions within or near direct
CC       repeats. There are more than a 100 copies of the gene for alpha/beta-
CC       gliadin per haploid genome.
CC   -!- SIMILARITY: Belongs to the gliadin/glutenin family. {ECO:0000305}.
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DR   EMBL; K03075; AAA34279.1; -; Genomic_DNA.
DR   AlphaFoldDB; P04727; -.
DR   PRIDE; P04727; -.
DR   Proteomes; UP000019116; Unplaced.
DR   ExpressionAtlas; P04727; baseline.
DR   GO; GO:0045735; F:nutrient reservoir activity; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.110.10; -; 2.
DR   InterPro; IPR036312; Bifun_inhib/LTP/seed_sf.
DR   InterPro; IPR016140; Bifunc_inhib/LTP/seed_store.
DR   InterPro; IPR001954; Glia_glutenin.
DR   PANTHER; PTHR33454; PTHR33454; 2.
DR   Pfam; PF00234; Tryp_alpha_amyl; 1.
DR   PRINTS; PR00208; GLIADGLUTEN.
DR   SMART; SM00499; AAI; 1.
DR   SUPFAM; SSF47699; SSF47699; 1.
PE   3: Inferred from homology;
KW   Allergen; Reference proteome; Repeat; Seed storage protein; Signal;
KW   Storage protein.
FT   SIGNAL          1..20
FT   CHAIN           21..313
FT                   /note="Alpha/beta-gliadin clone PW8142"
FT                   /id="PRO_0000032274"
FT   REGION          22..122
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          234..272
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        22..53
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        54..105
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        106..122
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   313 AA;  36118 MW;  BA1BD56378337514 CRC64;
     MKTFLILALV ATTATTAVRV PVPQLQPKNP SQQQPQEQVP LVQQQQFPGQ QQQFPPQQPY
     PQPQPFPSQQ PYLQLQPFPQ PQPFLPQLPY PQPQSFPPQQ PYPQQRPKYL QPQQPISQQQ
     AQQQQQQQQQ QQQQQQQQIL QQILQQQLIP CRDVVLQQHN IAHASSQVLQ QSTYQLLQQL
     CCQQLLQIPE QSRCQAIHNV VHAIIMHQQE QQQQLQQQQQ QQLQQQQQQQ QQQQQPSSQV
     SFQQPQQQYP SSQGSFQPSQ QNPQAQGSVQ PQQLPQFAEI RNLALQTLPA MCNVYIPPHC
     STTIAPFGIF GTN