ID   GDAP2_BOVIN             Reviewed;         497 AA.
AC   Q2KIX2;
DT   29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   07-MAR-2006, sequence version 1.
DT   03-AUG-2022, entry version 87.
DE   RecName: Full=Ganglioside-induced differentiation-associated protein 2;
GN   Name=GDAP2;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Testis;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the GDAP2 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BC112475; AAI12476.1; -; mRNA.
DR   RefSeq; NP_001039478.1; NM_001046013.2.
DR   AlphaFoldDB; Q2KIX2; -.
DR   SMR; Q2KIX2; -.
DR   STRING; 9913.ENSBTAP00000021791; -.
DR   PaxDb; Q2KIX2; -.
DR   PRIDE; Q2KIX2; -.
DR   GeneID; 508774; -.
DR   KEGG; bta:508774; -.
DR   CTD; 54834; -.
DR   eggNOG; KOG2633; Eukaryota.
DR   HOGENOM; CLU_026877_0_0_1; -.
DR   InParanoid; Q2KIX2; -.
DR   OrthoDB; 937161at2759; -.
DR   TreeFam; TF324164; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005096; F:GTPase activator activity; IBA:GO_Central.
DR   GO; GO:2001136; P:negative regulation of endocytic recycling; IBA:GO_Central.
DR   GO; GO:0007264; P:small GTPase mediated signal transduction; IBA:GO_Central.
DR   CDD; cd02905; Macro_GDAP2-like; 1.
DR   CDD; cd00170; SEC14; 1.
DR   Gene3D; 3.40.220.10; -; 1.
DR   Gene3D; 3.40.525.10; -; 1.
DR   InterPro; IPR001251; CRAL-TRIO_dom.
DR   InterPro; IPR036865; CRAL-TRIO_dom_sf.
DR   InterPro; IPR002589; Macro_dom.
DR   InterPro; IPR043472; Macro_dom-like.
DR   InterPro; IPR035793; Macro_GDAP2.
DR   Pfam; PF13716; CRAL_TRIO_2; 1.
DR   Pfam; PF01661; Macro; 1.
DR   SMART; SM00506; A1pp; 1.
DR   SMART; SM00516; SEC14; 1.
DR   SUPFAM; SSF52087; SSF52087; 1.
DR   SUPFAM; SSF52949; SSF52949; 1.
DR   PROSITE; PS51154; MACRO; 1.
PE   2: Evidence at transcript level;
KW   Phosphoprotein; Reference proteome.
FT   CHAIN           1..497
FT                   /note="Ganglioside-induced differentiation-associated
FT                   protein 2"
FT                   /id="PRO_0000331393"
FT   DOMAIN          43..223
FT                   /note="Macro"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00490"
FT   DOMAIN          333..481
FT                   /note="CRAL-TRIO"
FT   REGION          251..273
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         280
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9NXN4"
SQ   SEQUENCE   497 AA;  56263 MW;  CC92946F4ECDB935 CRC64;
     MDPLGAPSQF VDVDTLPSWG NSCEDQLNAS EIAAETYQEE TIRSPFLYNK DINGKVVLWK
     GDVALLNCTA IVNTSNESLT DKNPVSESIF MLAGPDLKED LQKLRGCRTG EAKLTKGFNL
     AARFIIHTVG PKYKSRYRTA AESSLYSCYR NVLQLAKEQS MSSVGFCVIN SAKRGYPLED
     ATHIALRTVR RFLEIHGETL EKVVFAVSEL EEATYQKLLP LYFPRSLKEE SRSLPCLPAD
     IGNAEGEPVV PERQIRISEK PGAPEDNQEE EDEGLGVDLS FIGSHAFARM EGDIDKQRRL
     ILQGQLSEAA LQKQHQRNYN RWLCQARSED LSDIASLKAL YQTGVDNCGR TVMVVVGRNI
     PVTLIDMDKA LLYFIHVMDH IAVKEYVLVY FHTLTSEYNH LDSDFLKKLY DVVDVKYKRN
     LKAVYFVHPT FRSKVSTWFF TTFSVSGLKD KIHHVDSLHQ LFSAISPEQI DFPPFVLEYD
     ARENGPYYTS YLPSPDL