GDAP2_DROME
ID GDAP2_DROME Reviewed; 540 AA.
AC Q7JUR6;
DT 29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 03-OCT-2006, sequence version 1.
DT 03-AUG-2022, entry version 110.
DE RecName: Full=Protein GDAP2 homolog {ECO:0000303|PubMed:30084953};
GN Name=Gdap2 {ECO:0000303|PubMed:30084953, ECO:0000312|FlyBase:FBgn0042135};
GN ORFNames=CG18812 {ECO:0000312|FlyBase:FBgn0042135};
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley; TISSUE=Head;
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
RN [4]
RP DISRUPTION PHENOTYPE.
RX PubMed=30084953; DOI=10.1093/brain/awy198;
RA Eidhof I., Baets J., Kamsteeg E.J., Deconinck T., van Ninhuijs L.,
RA Martin J.J., Schuele R., Zuechner S., De Jonghe P., Schenck A.,
RA van de Warrenburg B.P.;
RT "GDAP2 mutations implicate susceptibility to cellular stress in a new form
RT of cerebellar ataxia.";
RL Brain 141:2592-2604(2018).
CC -!- DISRUPTION PHENOTYPE: Shortened lifespan, impaired locomotor behavior,
CC and increased sensitivity to deleterious effects of stressors such as
CC reactive oxygen species and nutrient deprivation. Locomotor anomalies
CC include righting defects, reduced and uncoordinated walking behavior,
CC and compromised flight. {ECO:0000269|PubMed:30084953}.
CC -!- SIMILARITY: Belongs to the GDAP2 family. {ECO:0000305}.
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DR EMBL; AE013599; AAG22308.2; -; Genomic_DNA.
DR EMBL; AY122088; AAM52600.1; -; mRNA.
DR RefSeq; NP_724597.1; NM_165552.5.
DR AlphaFoldDB; Q7JUR6; -.
DR SMR; Q7JUR6; -.
DR BioGRID; 72830; 4.
DR IntAct; Q7JUR6; 1.
DR STRING; 7227.FBpp0088009; -.
DR PaxDb; Q7JUR6; -.
DR PRIDE; Q7JUR6; -.
DR DNASU; 59173; -.
DR EnsemblMetazoa; FBtr0088935; FBpp0088009; FBgn0042135.
DR GeneID; 59173; -.
DR KEGG; dme:Dmel_CG18812; -.
DR UCSC; CG18812-RC; d. melanogaster.
DR CTD; 54834; -.
DR FlyBase; FBgn0042135; Gdap2.
DR VEuPathDB; VectorBase:FBgn0042135; -.
DR eggNOG; KOG2633; Eukaryota.
DR GeneTree; ENSGT00940000156336; -.
DR InParanoid; Q7JUR6; -.
DR OMA; LYFPRDR; -.
DR PhylomeDB; Q7JUR6; -.
DR BioGRID-ORCS; 59173; 0 hits in 1 CRISPR screen.
DR GenomeRNAi; 59173; -.
DR PRO; PR:Q7JUR6; -.
DR Proteomes; UP000000803; Chromosome 2R.
DR Bgee; FBgn0042135; Expressed in adult Malpighian tubule (Drosophila) and 27 other tissues.
DR ExpressionAtlas; Q7JUR6; baseline and differential.
DR Genevisible; Q7JUR6; DM.
DR GO; GO:0006979; P:response to oxidative stress; IDA:FlyBase.
DR GO; GO:0042594; P:response to starvation; IDA:FlyBase.
DR CDD; cd02905; Macro_GDAP2-like; 1.
DR CDD; cd00170; SEC14; 1.
DR Gene3D; 3.40.220.10; -; 1.
DR Gene3D; 3.40.525.10; -; 1.
DR InterPro; IPR001251; CRAL-TRIO_dom.
DR InterPro; IPR036865; CRAL-TRIO_dom_sf.
DR InterPro; IPR002589; Macro_dom.
DR InterPro; IPR043472; Macro_dom-like.
DR InterPro; IPR035793; Macro_GDAP2.
DR Pfam; PF13716; CRAL_TRIO_2; 1.
DR Pfam; PF01661; Macro; 1.
DR SMART; SM00506; A1pp; 1.
DR SMART; SM00516; SEC14; 1.
DR SUPFAM; SSF52087; SSF52087; 1.
DR SUPFAM; SSF52949; SSF52949; 1.
DR PROSITE; PS50191; CRAL_TRIO; 1.
DR PROSITE; PS51154; MACRO; 1.
PE 2: Evidence at transcript level;
KW Reference proteome.
FT CHAIN 1..540
FT /note="Protein GDAP2 homolog"
FT /id="PRO_0000331401"
FT DOMAIN 56..235
FT /note="Macro"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00490"
FT DOMAIN 371..528
FT /note="CRAL-TRIO"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00056"
SQ SEQUENCE 540 AA; 61441 MW; 0A99F9BEFEB5F24C CRC64;
MRLDTNSNVD FKAFESSSSS CPVKLDNLAT WGGSQKTDTR LPITDYSNLG GPRHNRSPFP
LCKDVNNRFV IWDGDMTTLE VDAITNTSDE TLTESNSISE RIFAVAGNQL REELSTTVKE
CRTGDVRITR GYNLPAKYVL HTVAPAYREK FKTAAENTLH CCYRNVLCKA KELNLHTIAL
CNISAHQKSF PADVAAHIAL RTIRRYLDKC TLQVVILCVG SSERGTYEVL APLYFPRDQL
EERSALWQLP KDIGGEFGEP QHPDPDRQIR IIRNPQHSVH MRHHLADDDS DVSPHDMEGN
SSDLEYGARD MNGLSLNSYS SGLQAQLQRD LDRQHLLSDR PRTGVYENVI SEGVEGIEHQ
ERYERLLRRA QVEDLTEVSG IGCLYQSGVD RLGRPVIVFC GKWFPAQNID LEKALLYLIK
LLDPIVKGDY VISYFHTLTS TNNYPSLHWL REVYSVLPYK YKKNLKAFYI VHPTFWTKMM
TWWFTTFMAP AIKAKVHSLP GVEHLYSAIT KDQLEIPAYI TEYDMATNGL HYFNPVPTAS
