GDAP2_MOUSE
ID GDAP2_MOUSE Reviewed; 498 AA.
AC Q9DBL2; O88742; Q8C468;
DT 29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 147.
DE RecName: Full=Ganglioside-induced differentiation-associated protein 2;
GN Name=Gdap2;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], INDUCTION, DEVELOPMENTAL STAGE, AND TISSUE
RP SPECIFICITY.
RC STRAIN=ICR; TISSUE=Brain;
RX PubMed=10217254; DOI=10.1046/j.1471-4159.1999.0721781.x;
RA Liu H., Nakagawa T., Kanematsu T., Uchida T., Tsuji S.;
RT "Isolation of 10 differentially expressed cDNAs in differentiated Neuro2a
RT cells induced through controlled expression of the GD3 synthase gene.";
RL J. Neurochem. 72:1781-1790(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC STRAIN=C57BL/6J; TISSUE=Amnion, Liver, and Spinal cord;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=FVB/N; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Spleen;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9DBL2-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9DBL2-2; Sequence=VSP_033187;
CC -!- TISSUE SPECIFICITY: Expressed at high levels in brain and testis, and
CC at low levels in liver and kidney. {ECO:0000269|PubMed:10217254}.
CC -!- DEVELOPMENTAL STAGE: In the brain, expression starts at 12 dpc and
CC increases until adulthood. {ECO:0000269|PubMed:10217254}.
CC -!- INDUCTION: By differentiation in neurons.
CC {ECO:0000269|PubMed:10217254}.
CC -!- SIMILARITY: Belongs to the GDAP2 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAA76894.1; Type=Erroneous translation; Note=Wrong choice of frame.; Evidence={ECO:0000305};
CC Sequence=CAA76894.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; Y17851; CAA76894.1; ALT_SEQ; mRNA.
DR EMBL; AK004887; BAB23645.1; -; mRNA.
DR EMBL; AK082958; BAC38709.1; -; mRNA.
DR EMBL; AK146835; BAE27470.1; -; mRNA.
DR EMBL; AK166799; BAE39027.1; -; mRNA.
DR EMBL; AK166859; BAE39075.1; -; mRNA.
DR EMBL; AC102209; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL606742; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC025070; AAH25070.1; -; mRNA.
DR CCDS; CCDS17675.1; -. [Q9DBL2-1]
DR RefSeq; NP_034399.1; NM_010269.3. [Q9DBL2-1]
DR RefSeq; XP_006501064.1; XM_006501001.2. [Q9DBL2-1]
DR AlphaFoldDB; Q9DBL2; -.
DR SMR; Q9DBL2; -.
DR STRING; 10090.ENSMUSP00000029459; -.
DR iPTMnet; Q9DBL2; -.
DR PhosphoSitePlus; Q9DBL2; -.
DR EPD; Q9DBL2; -.
DR MaxQB; Q9DBL2; -.
DR PaxDb; Q9DBL2; -.
DR PeptideAtlas; Q9DBL2; -.
DR PRIDE; Q9DBL2; -.
DR ProteomicsDB; 273035; -. [Q9DBL2-1]
DR ProteomicsDB; 273036; -. [Q9DBL2-2]
DR Antibodypedia; 46950; 120 antibodies from 20 providers.
DR DNASU; 14547; -.
DR Ensembl; ENSMUST00000029459; ENSMUSP00000029459; ENSMUSG00000027865. [Q9DBL2-1]
DR Ensembl; ENSMUST00000106997; ENSMUSP00000102610; ENSMUSG00000027865. [Q9DBL2-2]
DR GeneID; 14547; -.
DR KEGG; mmu:14547; -.
DR UCSC; uc008qqq.2; mouse. [Q9DBL2-2]
DR UCSC; uc008qqr.2; mouse. [Q9DBL2-1]
DR CTD; 54834; -.
DR MGI; MGI:1338001; Gdap2.
DR VEuPathDB; HostDB:ENSMUSG00000027865; -.
DR eggNOG; KOG2633; Eukaryota.
DR GeneTree; ENSGT00940000156336; -.
DR HOGENOM; CLU_026877_0_0_1; -.
DR InParanoid; Q9DBL2; -.
DR OMA; LYFPRDR; -.
DR OrthoDB; 937161at2759; -.
DR PhylomeDB; Q9DBL2; -.
DR TreeFam; TF324164; -.
DR BioGRID-ORCS; 14547; 2 hits in 73 CRISPR screens.
DR ChiTaRS; Gdap2; mouse.
DR PRO; PR:Q9DBL2; -.
DR Proteomes; UP000000589; Chromosome 3.
DR RNAct; Q9DBL2; protein.
DR Bgee; ENSMUSG00000027865; Expressed in cleaving embryo and 268 other tissues.
DR ExpressionAtlas; Q9DBL2; baseline and differential.
DR Genevisible; Q9DBL2; MM.
DR GO; GO:0032526; P:response to retinoic acid; IDA:MGI.
DR CDD; cd02905; Macro_GDAP2-like; 1.
DR CDD; cd00170; SEC14; 1.
DR Gene3D; 3.40.220.10; -; 1.
DR Gene3D; 3.40.525.10; -; 1.
DR InterPro; IPR001251; CRAL-TRIO_dom.
DR InterPro; IPR036865; CRAL-TRIO_dom_sf.
DR InterPro; IPR002589; Macro_dom.
DR InterPro; IPR043472; Macro_dom-like.
DR InterPro; IPR035793; Macro_GDAP2.
DR Pfam; PF13716; CRAL_TRIO_2; 1.
DR Pfam; PF01661; Macro; 1.
DR SMART; SM00506; A1pp; 1.
DR SMART; SM00516; SEC14; 1.
DR SUPFAM; SSF52087; SSF52087; 1.
DR SUPFAM; SSF52949; SSF52949; 1.
DR PROSITE; PS51154; MACRO; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Phosphoprotein; Reference proteome.
FT CHAIN 1..498
FT /note="Ganglioside-induced differentiation-associated
FT protein 2"
FT /id="PRO_0000331396"
FT DOMAIN 43..223
FT /note="Macro"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00490"
FT DOMAIN 334..482
FT /note="CRAL-TRIO"
FT REGION 248..275
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 281
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9NXN4"
FT VAR_SEQ 484..498
FT /note="ENGPYFASYPPSPDL -> VSACPPLPGVVCRCAAAAGVSIWVCHGAAGVSL
FT CVSCYMPTMKAASQSFCLITCRYTPVCSVC (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_033187"
SQ SEQUENCE 498 AA; 56269 MW; E9968D639F8A43DB CRC64;
MDPLGAPSQF VDVDTLLSWG DSYEDEVDCA DSTAEAFQED ASRSPFVYSR DVNGKVVLWK
GDVALLNCTA IVNTSNESLT DKNPVSESIF MLAGPDLKED LQKLKGCRTG EAKLTKGFNL
AARFIIHTVG PKYKSRYRTA AESSLYSCYR NVLQLAKEQS MSSVGFCVIN SAKRGYPLED
ATHIALRTVR RFLEIHGENI EKVVFAVSEL EEATYQKLLP LYFPRSLKEE IRSLPYLPAD
IGNAEGEPVV PERQIRISEK PGASEDNEEE DEDEGLGVDL SFIGSHAFAR MEGDIDKQRK
LILQGQLSEA ALQKQHQRNY NRWLCQARSE DLSDIASLKA LYQTGVDNCG RTVMVVVGRN
IPVTLIDMDK ALLYFIHVMD HIAVKEYVLV YFHTLTSDYN HLDSDFLKKL YDVVDIKYKR
NLKAVYFVHP TFRSKVSTWF FTTFSVSGLK DKIHHVDSLQ QLFSAISPEQ IDFPPFVLEY
DARENGPYFA SYPPSPDL
