ID   GDAS1_HUMAN             Reviewed;         250 AA.
AC   Q5U4N7; A6PVI8;
DT   29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-MAY-2009, sequence version 2.
DT   03-AUG-2022, entry version 96.
DE   RecName: Full=Protein GDF5-AS1, mitochondrial;
DE   AltName: Full=GDF5 antisense RNA 1 {ECO:0000312|HGNC:HGNC:33435};
DE   AltName: Full=Growth/differentiation factor 5 opposite strand transcript protein;
DE   Flags: Precursor;
GN   Name=GDF5-AS1 {ECO:0000312|HGNC:HGNC:33435}; Synonyms=GDF5OS;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=11780052; DOI=10.1038/414865a;
RA   Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R.,
RA   Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L.,
RA   Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P.,
RA   Bird C.P., Blakey S.E., Bridgeman A.M., Brown A.J., Buck D., Burrill W.D.,
RA   Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G.,
RA   Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E.,
RA   Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D.,
RA   Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P.,
RA   Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E.,
RA   Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J.,
RA   Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D.,
RA   Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S.,
RA   Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D.,
RA   Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A.,
RA   Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T.,
RA   Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I.,
RA   Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M.,
RA   Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D.,
RA   Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M.,
RA   Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A.,
RA   Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L.,
RA   Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L.,
RA   Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.;
RT   "The DNA sequence and comparative analysis of human chromosome 20.";
RL   Nature 414:865-871(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Ovary;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- INTERACTION:
CC       Q5U4N7; Q6NTF9-3: RHBDD2; NbExp=3; IntAct=EBI-17590774, EBI-17589229;
CC   -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000305}.
CC   -!- CAUTION: Product of a dubious CDS prediction. {ECO:0000305}.
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DR   EMBL; AL121586; CAO03344.1; -; Genomic_DNA.
DR   EMBL; BC085019; AAH85019.1; -; mRNA.
DR   AlphaFoldDB; Q5U4N7; -.
DR   SMR; Q5U4N7; -.
DR   IntAct; Q5U4N7; 2.
DR   iPTMnet; Q5U4N7; -.
DR   PhosphoSitePlus; Q5U4N7; -.
DR   BioMuta; GDF5OS; -.
DR   PaxDb; Q5U4N7; -.
DR   PRIDE; Q5U4N7; -.
DR   ProteomicsDB; 65226; -.
DR   UCSC; uc061wmk.1; human.
DR   GeneCards; GDF5-AS1; -.
DR   HGNC; HGNC:33435; GDF5-AS1.
DR   MalaCards; GDF5-AS1; -.
DR   neXtProt; NX_Q5U4N7; -.
DR   eggNOG; ENOG502TE8X; Eukaryota.
DR   HOGENOM; CLU_074369_0_0_1; -.
DR   InParanoid; Q5U4N7; -.
DR   PhylomeDB; Q5U4N7; -.
DR   PathwayCommons; Q5U4N7; -.
DR   SignaLink; Q5U4N7; -.
DR   Pharos; Q5U4N7; Tdark.
DR   PRO; PR:Q5U4N7; -.
DR   Proteomes; UP000005640; Unplaced.
DR   RNAct; Q5U4N7; protein.
DR   GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
DR   InterPro; IPR039711; GDF5OS.
DR   PANTHER; PTHR42152; PTHR42152; 1.
PE   5: Uncertain;
KW   Mitochondrion; Reference proteome; Transit peptide.
FT   TRANSIT         1..48
FT                   /note="Mitochondrion"
FT                   /evidence="ECO:0000255"
FT   CHAIN           49..250
FT                   /note="Protein GDF5-AS1, mitochondrial"
FT                   /id="PRO_0000289167"
FT   REGION          86..108
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          124..148
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          204..250
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        124..140
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        204..223
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        144
FT                   /note="E -> A (in Ref. 2; AAH85019)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   250 AA;  28211 MW;  11AEE309332C6EE5 CRC64;
     MIQSSQPMSL KLTCSAFRLQ RALRFLLGRL PWRVASGARR FRRWLNRYSY TVLSSWPERA
     LISLKNRSRF LVRPNTRNRA FSWTCRAARS KPRPRRSTAL PRSQASSSRH SWAEFLKFRK
     SFQMSNTSQP DPSRPGTERT SSKEAGCRPL GQLDSFSWAA RPPPGAAGLA VSEGFFRKIR
     SSAPSSPSFS RALMSNTYLC FLTTGPRSSR ENTQKSFPAT SPREPVTSRL RGKAPALSPS
     RELSFTSAPF