ID   GDC_BOVIN               Reviewed;         330 AA.
AC   Q01888;
DT   01-APR-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-APR-1993, sequence version 1.
DT   03-AUG-2022, entry version 118.
DE   RecName: Full=Solute carrier family 25 member 16;
DE   AltName: Full=Graves disease carrier protein;
DE            Short=GDC;
DE   AltName: Full=Mitochondrial solute carrier protein homolog;
GN   Name=SLC25A16; Synonyms=GDA, GDC;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC   TISSUE=Heart;
RX   PubMed=1457817; DOI=10.3109/10425179209033999;
RA   Fiermonte G., Runswick M.J., Walker J.E., Palmieri F.;
RT   "Sequence and pattern of expression of a bovine homologue of a human
RT   mitochondrial transport protein associated with Grave's disease.";
RL   DNA Seq. 3:71-78(1992).
CC   -!- FUNCTION: Required for the accumulation of coenzyme A in the
CC       mitochondrial matrix. {ECO:0000250|UniProtKB:P16260}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC       {ECO:0000250|UniProtKB:P16260}; Multi-pass membrane protein
CC       {ECO:0000255}.
CC   -!- TISSUE SPECIFICITY: Mostly in thyroid, liver, lung, kidney and to a
CC       lesser extent in heart and skeletal muscle.
CC       {ECO:0000269|PubMed:1457817}.
CC   -!- SIMILARITY: Belongs to the mitochondrial carrier (TC 2.A.29) family.
CC       {ECO:0000305}.
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DR   EMBL; X66035; CAA46834.1; -; mRNA.
DR   PIR; S26596; S26596.
DR   RefSeq; NP_777097.1; NM_174672.2.
DR   AlphaFoldDB; Q01888; -.
DR   SMR; Q01888; -.
DR   STRING; 9913.ENSBTAP00000031299; -.
DR   TCDB; 2.A.29.12.1; the mitochondrial carrier (mc) family.
DR   PaxDb; Q01888; -.
DR   GeneID; 282524; -.
DR   KEGG; bta:282524; -.
DR   CTD; 8034; -.
DR   eggNOG; KOG0752; Eukaryota.
DR   InParanoid; Q01888; -.
DR   OrthoDB; 612054at2759; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0055085; P:transmembrane transport; IEA:InterPro.
DR   Gene3D; 1.50.40.10; -; 1.
DR   InterPro; IPR002167; Graves_DC.
DR   InterPro; IPR002067; Mit_carrier.
DR   InterPro; IPR018108; Mitochondrial_sb/sol_carrier.
DR   InterPro; IPR023395; Mt_carrier_dom_sf.
DR   Pfam; PF00153; Mito_carr; 3.
DR   PRINTS; PR00928; GRAVESDC.
DR   PRINTS; PR00926; MITOCARRIER.
DR   SUPFAM; SSF103506; SSF103506; 1.
DR   PROSITE; PS50920; SOLCAR; 3.
PE   2: Evidence at transcript level;
KW   Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW   Repeat; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..330
FT                   /note="Solute carrier family 25 member 16"
FT                   /id="PRO_0000090615"
FT   TRANSMEM        33..52
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        95..112
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        132..149
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        189..209
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        242..262
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        297..317
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   REPEAT          32..118
FT                   /note="Solcar 1"
FT   REPEAT          126..214
FT                   /note="Solcar 2"
FT   REPEAT          236..326
FT                   /note="Solcar 3"
SQ   SEQUENCE   330 AA;  36085 MW;  4C614701D2B8DEA9 CRC64;
     MAAAAAALAA TEPPPAMPQA AGAGGPAARR DFYWLRSFLA GGIAGCCAKT TVAPLDRVKV
     LLQAHNHHYR HLGVFSTLRA VPKKEGYLGL YKGNGAMMIR IFPYGAIQFM AFEHYKTLIT
     TKLGVSGHVH RLMAGSMAGM TAVICTYPLD MVRVRLAFQV KGEHTYTGII HAFKTIYAKE
     GGFLGFYRGL MPTILGMAPY AGVSFFTFGT LKSVGLSYAP TLLGRPSSDN PNVLVLKTHI
     NLLCGGVAGA IAQTISYPFD VTRRRMQLGA VLPEFEKCLT MRETMKYVYG HHGIRKGLYR
     GLSLNYIRCV PSQAVAFTTY ELMKQFFHLN