GDC_HUMAN
ID GDC_HUMAN Reviewed; 332 AA.
AC P16260; Q8N2U1;
DT 01-AUG-1990, integrated into UniProtKB/Swiss-Prot.
DT 25-NOV-2008, sequence version 3.
DT 03-AUG-2022, entry version 190.
DE RecName: Full=Solute carrier family 25 member 16;
DE AltName: Full=Graves disease autoantigen;
DE Short=GDA;
DE AltName: Full=Graves disease carrier protein;
DE Short=GDC;
DE AltName: Full=Mitochondrial solute carrier protein homolog;
GN Name=SLC25A16; Synonyms=GDA;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Thyroid;
RX PubMed=2575220; DOI=10.1210/mend-3-9-1498;
RA Zarrilli R., Oates E.L., McBride O.W., Lerman M.I., Chan J.Y.,
RA Santisteban P., Ursini M.V., Notkins A.L., Kohn L.D.;
RT "Sequence and chromosomal assignment of a novel cDNA identified by
RT immunoscreening of a thyroid expression library: similarity to a family of
RT mitochondrial solute carrier proteins.";
RL Mol. Endocrinol. 3:1498-1505(1989).
RN [2]
RP SEQUENCE REVISION TO C-TERMINUS.
RX PubMed=1457817; DOI=10.3109/10425179209033999;
RA Fiermonte G., Runswick M.J., Walker J.E., Palmieri F.;
RT "Sequence and pattern of expression of a bovine homologue of a human
RT mitochondrial transport protein associated with Grave's disease.";
RL DNA Seq. 3:71-78(1992).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Colon;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15164054; DOI=10.1038/nature02462;
RA Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L.,
RA Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K.,
RA Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L.,
RA Taylor A., Battles J., Bird C.P., Ainscough R., Almeida J.P.,
RA Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y.,
RA Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N.,
RA Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A.,
RA Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C.,
RA Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D.,
RA Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C.,
RA Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K.,
RA Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A.,
RA Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S.,
RA McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S.,
RA Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V.,
RA Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A.,
RA Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M.,
RA Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A.,
RA Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P.,
RA Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y.,
RA Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D.,
RA Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.;
RT "The DNA sequence and comparative analysis of human chromosome 10.";
RL Nature 429:375-381(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [7]
RP FUNCTION, AND SUBCELLULAR LOCATION.
RX PubMed=11158296; DOI=10.1128/mcb.21.4.1089-1097.2001;
RA Prohl C., Pelzer W., Diekert K., Kmita H., Bedekovics T., Kispal G.,
RA Lill R.;
RT "The yeast mitochondrial carrier Leu5p and its human homologue Graves'
RT disease protein are required for accumulation of coenzyme A in the
RT matrix.";
RL Mol. Cell. Biol. 21:1089-1097(2001).
RN [8]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA Elledge S.J., Gygi S.P.;
RT "A quantitative atlas of mitotic phosphorylation.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
CC -!- FUNCTION: Required for the accumulation of coenzyme A in the
CC mitochondrial matrix. {ECO:0000269|PubMed:11158296}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC {ECO:0000269|PubMed:11158296}; Multi-pass membrane protein
CC {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the mitochondrial carrier (TC 2.A.29) family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAA36329.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; M31659; AAA36329.1; ALT_FRAME; mRNA.
DR EMBL; AK290255; BAF82944.1; -; mRNA.
DR EMBL; AL713888; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471083; EAW54298.1; -; Genomic_DNA.
DR EMBL; BC030266; AAH30266.1; -; mRNA.
DR CCDS; CCDS7280.1; -.
DR PIR; A40141; A40141.
DR RefSeq; NP_689920.1; NM_152707.3.
DR RefSeq; XP_011538513.1; XM_011540211.2.
DR AlphaFoldDB; P16260; -.
DR SMR; P16260; -.
DR BioGRID; 113727; 36.
DR IntAct; P16260; 13.
DR STRING; 9606.ENSP00000476815; -.
DR TCDB; 2.A.29.12.3; the mitochondrial carrier (mc) family.
DR GlyGen; P16260; 3 sites, 1 O-linked glycan (3 sites).
DR iPTMnet; P16260; -.
DR PhosphoSitePlus; P16260; -.
DR SwissPalm; P16260; -.
DR BioMuta; SLC25A16; -.
DR DMDM; 215274156; -.
DR EPD; P16260; -.
DR jPOST; P16260; -.
DR MassIVE; P16260; -.
DR MaxQB; P16260; -.
DR PaxDb; P16260; -.
DR PeptideAtlas; P16260; -.
DR PRIDE; P16260; -.
DR ProteomicsDB; 53331; -.
DR Antibodypedia; 28525; 72 antibodies from 17 providers.
DR DNASU; 8034; -.
DR Ensembl; ENST00000609923.6; ENSP00000476815.1; ENSG00000122912.15.
DR GeneID; 8034; -.
DR KEGG; hsa:8034; -.
DR MANE-Select; ENST00000609923.6; ENSP00000476815.1; NM_152707.4; NP_689920.1.
DR UCSC; uc001joi.4; human.
DR CTD; 8034; -.
DR DisGeNET; 8034; -.
DR GeneCards; SLC25A16; -.
DR HGNC; HGNC:10986; SLC25A16.
DR HPA; ENSG00000122912; Low tissue specificity.
DR MalaCards; SLC25A16; -.
DR MIM; 139080; gene.
DR neXtProt; NX_P16260; -.
DR OpenTargets; ENSG00000122912; -.
DR PharmGKB; PA35862; -.
DR VEuPathDB; HostDB:ENSG00000122912; -.
DR eggNOG; KOG0752; Eukaryota.
DR GeneTree; ENSGT00940000157520; -.
DR HOGENOM; CLU_015166_10_1_1; -.
DR InParanoid; P16260; -.
DR OMA; KLPGMWA; -.
DR OrthoDB; 1173026at2759; -.
DR PhylomeDB; P16260; -.
DR TreeFam; TF314806; -.
DR PathwayCommons; P16260; -.
DR Reactome; R-HSA-196783; Coenzyme A biosynthesis.
DR SignaLink; P16260; -.
DR BioGRID-ORCS; 8034; 11 hits in 1081 CRISPR screens.
DR ChiTaRS; SLC25A16; human.
DR GenomeRNAi; 8034; -.
DR Pharos; P16260; Tbio.
DR PRO; PR:P16260; -.
DR Proteomes; UP000005640; Chromosome 10.
DR RNAct; P16260; protein.
DR Bgee; ENSG00000122912; Expressed in jejunal mucosa and 182 other tissues.
DR ExpressionAtlas; P16260; baseline and differential.
DR Genevisible; P16260; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005743; C:mitochondrial inner membrane; TAS:Reactome.
DR GO; GO:0005739; C:mitochondrion; IDA:HPA.
DR GO; GO:0015297; F:antiporter activity; NAS:UniProtKB.
DR GO; GO:0015291; F:secondary active transmembrane transporter activity; TAS:Reactome.
DR GO; GO:0015937; P:coenzyme A biosynthetic process; TAS:Reactome.
DR GO; GO:0006839; P:mitochondrial transport; NAS:UniProtKB.
DR Gene3D; 1.50.40.10; -; 1.
DR InterPro; IPR002167; Graves_DC.
DR InterPro; IPR002067; Mit_carrier.
DR InterPro; IPR018108; Mitochondrial_sb/sol_carrier.
DR InterPro; IPR023395; Mt_carrier_dom_sf.
DR Pfam; PF00153; Mito_carr; 3.
DR PRINTS; PR00928; GRAVESDC.
DR PRINTS; PR00926; MITOCARRIER.
DR SUPFAM; SSF103506; SSF103506; 1.
DR PROSITE; PS50920; SOLCAR; 3.
PE 1: Evidence at protein level;
KW Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW Repeat; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..332
FT /note="Solute carrier family 25 member 16"
FT /id="PRO_0000090616"
FT TRANSMEM 37..57
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TRANSMEM 88..108
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TRANSMEM 134..154
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TRANSMEM 191..211
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TRANSMEM 244..264
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TRANSMEM 299..319
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT REPEAT 34..120
FT /note="Solcar 1"
FT REPEAT 128..216
FT /note="Solcar 2"
FT REPEAT 238..328
FT /note="Solcar 3"
FT CONFLICT 21
FT /note="Q -> G (in Ref. 1; AAA36329)"
FT /evidence="ECO:0000305"
FT CONFLICT 44
FT /note="G -> S (in Ref. 1; AAA36329)"
FT /evidence="ECO:0000305"
FT CONFLICT 149..151
FT /note="YPL -> DPV (in Ref. 1; AAA36329)"
FT /evidence="ECO:0000305"
FT CONFLICT 167
FT /note="S -> R (in Ref. 1; AAA36329)"
FT /evidence="ECO:0000305"
FT CONFLICT 227
FT /note="R -> S (in Ref. 1; AAA36329)"
FT /evidence="ECO:0000305"
FT CONFLICT 251
FT /note="G -> R (in Ref. 1; AAA36329)"
FT /evidence="ECO:0000305"
FT CONFLICT 290
FT /note="V -> D (in Ref. 1; AAA36329)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 332 AA; 36224 MW; 71C2C3D413F80246 CRC64;
MAAATAAAAL AAADPPPAMP QAAGAGGPTT RRDFYWLRSF LAGGIAGCCA KTTVAPLDRV
KVLLQAHNHH YKHLGVFSAL RAVPQKEGFL GLYKGNGAMM IRIFPYGAIQ FMAFEHYKTL
ITTKLGISGH VHRLMAGSMA GMTAVICTYP LDMVRVRLAF QVKGEHSYTG IIHAFKTIYA
KEGGFFGFYR GLMPTILGMA PYAGVSFFTF GTLKSVGLSH APTLLGRPSS DNPNVLVLKT
HVNLLCGGVA GAIAQTISYP FDVTRRRMQL GTVLPEFEKC LTMRDTMKYV YGHHGIRKGL
YRGLSLNYIR CIPSQAVAFT TYELMKQFFH LN
