GDC_MOUSE
ID GDC_MOUSE Reviewed; 332 AA.
AC Q8C0K5; B2RSS4; Q6P6K8;
DT 06-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 144.
DE RecName: Full=Solute carrier family 25 member 16;
DE AltName: Full=Graves disease carrier protein homolog;
DE Short=GDC;
DE AltName: Full=Mitochondrial solute carrier protein homolog;
GN Name=Slc25a16; Synonyms=Gda;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=C57BL/6J; TISSUE=Thymus;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Brain, Jaw, and Limb;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brown adipose tissue, Kidney, and Liver;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Required for the accumulation of coenzyme A in the
CC mitochondrial matrix. {ECO:0000250|UniProtKB:P16260}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC {ECO:0000250|UniProtKB:P16260}; Multi-pass membrane protein
CC {ECO:0000255}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8C0K5-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8C0K5-2; Sequence=VSP_016549, VSP_016550;
CC -!- SIMILARITY: Belongs to the mitochondrial carrier (TC 2.A.29) family.
CC {ECO:0000305}.
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DR EMBL; AK030865; BAC27163.1; -; mRNA.
DR EMBL; BC062168; AAH62168.1; -; mRNA.
DR EMBL; BC138983; AAI38984.1; -; mRNA.
DR EMBL; BC138984; AAI38985.1; -; mRNA.
DR CCDS; CCDS23893.1; -. [Q8C0K5-1]
DR RefSeq; NP_780403.1; NM_175194.2. [Q8C0K5-1]
DR AlphaFoldDB; Q8C0K5; -.
DR SMR; Q8C0K5; -.
DR IntAct; Q8C0K5; 1.
DR STRING; 10090.ENSMUSP00000043370; -.
DR PhosphoSitePlus; Q8C0K5; -.
DR jPOST; Q8C0K5; -.
DR MaxQB; Q8C0K5; -.
DR PaxDb; Q8C0K5; -.
DR PeptideAtlas; Q8C0K5; -.
DR PRIDE; Q8C0K5; -.
DR ProteomicsDB; 273037; -. [Q8C0K5-1]
DR ProteomicsDB; 273038; -. [Q8C0K5-2]
DR Antibodypedia; 28525; 72 antibodies from 17 providers.
DR DNASU; 73132; -.
DR Ensembl; ENSMUST00000044977; ENSMUSP00000043370; ENSMUSG00000071253. [Q8C0K5-1]
DR GeneID; 73132; -.
DR KEGG; mmu:73132; -.
DR UCSC; uc007fjh.1; mouse. [Q8C0K5-1]
DR UCSC; uc029qye.1; mouse. [Q8C0K5-2]
DR CTD; 8034; -.
DR MGI; MGI:1920382; Slc25a16.
DR VEuPathDB; HostDB:ENSMUSG00000071253; -.
DR eggNOG; KOG0752; Eukaryota.
DR GeneTree; ENSGT00940000157520; -.
DR InParanoid; Q8C0K5; -.
DR OMA; KLPGMWA; -.
DR OrthoDB; 1173026at2759; -.
DR PhylomeDB; Q8C0K5; -.
DR TreeFam; TF314806; -.
DR Reactome; R-MMU-196783; Coenzyme A biosynthesis.
DR BioGRID-ORCS; 73132; 2 hits in 73 CRISPR screens.
DR ChiTaRS; Slc25a16; mouse.
DR PRO; PR:Q8C0K5; -.
DR Proteomes; UP000000589; Chromosome 10.
DR RNAct; Q8C0K5; protein.
DR Bgee; ENSMUSG00000071253; Expressed in left lobe of liver and 213 other tissues.
DR ExpressionAtlas; Q8C0K5; baseline and differential.
DR Genevisible; Q8C0K5; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005739; C:mitochondrion; HDA:MGI.
DR GO; GO:0055085; P:transmembrane transport; IEA:InterPro.
DR Gene3D; 1.50.40.10; -; 1.
DR InterPro; IPR002167; Graves_DC.
DR InterPro; IPR002067; Mit_carrier.
DR InterPro; IPR018108; Mitochondrial_sb/sol_carrier.
DR InterPro; IPR023395; Mt_carrier_dom_sf.
DR Pfam; PF00153; Mito_carr; 3.
DR PRINTS; PR00928; GRAVESDC.
DR PRINTS; PR00926; MITOCARRIER.
DR SUPFAM; SSF103506; SSF103506; 1.
DR PROSITE; PS50920; SOLCAR; 3.
PE 1: Evidence at protein level;
KW Alternative splicing; Membrane; Mitochondrion;
KW Mitochondrion inner membrane; Reference proteome; Repeat; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..332
FT /note="Solute carrier family 25 member 16"
FT /id="PRO_0000090617"
FT TRANSMEM 37..57
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TRANSMEM 88..108
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TRANSMEM 134..154
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TRANSMEM 191..211
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TRANSMEM 244..264
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TRANSMEM 299..319
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT REPEAT 34..120
FT /note="Solcar 1"
FT REPEAT 128..216
FT /note="Solcar 2"
FT REPEAT 238..328
FT /note="Solcar 3"
FT VAR_SEQ 76..81
FT /note="VLSTLR -> EFYMQS (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_016549"
FT VAR_SEQ 82..332
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_016550"
SQ SEQUENCE 332 AA; 36220 MW; FEA5E7C41DF2C757 CRC64;
MAALVAAAAL AAAEPAPAVP QAAGSGGPTS RRDFYWLRSF LAGGIAGCCA KTTVAPLDRV
KVLLQAHNRH YKHLGVLSTL RAVPQKEGYL GLYKGNGAMM IRIFPYGAIQ FMAFEHYKTF
ITTKLGVSGH VHRLMAGSMA GMTAVICTYP LDVVRVRLAF QVKGEHTYSG IIHAFKTIYA
KEGGFLGFYR GLMPTILGMA PYAGVSFFTF GTLKSVGLSY APALLGRPSS DNPNVLVLKT
HINLLCGGVA GAIAQTISYP FDVTRRRMQL GAVLPEFEKC LTMRETMKYV YGQHGIRRGL
YRGLSLNYIR CIPSQAVAFT TYELMKQFFH LN
