ID   GDC_RAT                 Reviewed;         322 AA.
AC   P16261;
DT   01-AUG-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1990, sequence version 1.
DT   03-AUG-2022, entry version 126.
DE   RecName: Full=Solute carrier family 25 member 16;
DE   AltName: Full=Graves disease carrier protein;
DE            Short=GDC;
DE   AltName: Full=Mitochondrial solute carrier protein homolog;
DE   Flags: Fragment;
GN   Name=Slc25a16; Synonyms=Gda;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Thyroid;
RX   PubMed=2575220; DOI=10.1210/mend-3-9-1498;
RA   Zarrilli R., Oates E.L., McBride O.W., Lerman M.I., Chan J.Y.,
RA   Santisteban P., Ursini M.V., Notkins A.L., Kohn L.D.;
RT   "Sequence and chromosomal assignment of a novel cDNA identified by
RT   immunoscreening of a thyroid expression library: similarity to a family of
RT   mitochondrial solute carrier proteins.";
RL   Mol. Endocrinol. 3:1498-1505(1989).
CC   -!- FUNCTION: Required for the accumulation of coenzyme A in the
CC       mitochondrial matrix. {ECO:0000250|UniProtKB:P16260}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC       {ECO:0000250|UniProtKB:P16260}; Multi-pass membrane protein
CC       {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the mitochondrial carrier (TC 2.A.29) family.
CC       {ECO:0000305}.
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DR   EMBL; M32973; AAA41639.1; -; mRNA.
DR   AlphaFoldDB; P16261; -.
DR   SMR; P16261; -.
DR   STRING; 10116.ENSRNOP00000052899; -.
DR   PaxDb; P16261; -.
DR   PeptideAtlas; P16261; -.
DR   PRIDE; P16261; -.
DR   UCSC; RGD:1311311; rat.
DR   RGD; 1311311; Slc25a16.
DR   eggNOG; KOG0752; Eukaryota.
DR   InParanoid; P16261; -.
DR   Reactome; R-RNO-196783; Coenzyme A biosynthesis.
DR   Proteomes; UP000002494; Unplaced.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0055085; P:transmembrane transport; IEA:InterPro.
DR   Gene3D; 1.50.40.10; -; 1.
DR   InterPro; IPR002167; Graves_DC.
DR   InterPro; IPR002067; Mit_carrier.
DR   InterPro; IPR018108; Mitochondrial_sb/sol_carrier.
DR   InterPro; IPR023395; Mt_carrier_dom_sf.
DR   Pfam; PF00153; Mito_carr; 3.
DR   PRINTS; PR00928; GRAVESDC.
DR   PRINTS; PR00926; MITOCARRIER.
DR   SUPFAM; SSF103506; SSF103506; 1.
DR   PROSITE; PS50920; SOLCAR; 3.
PE   2: Evidence at transcript level;
KW   Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW   Repeat; Transmembrane; Transport.
FT   CHAIN           1..>322
FT                   /note="Solute carrier family 25 member 16"
FT                   /id="PRO_0000090618"
FT   REPEAT          34..120
FT                   /note="Solcar 1"
FT   REPEAT          128..219
FT                   /note="Solcar 2"
FT   REPEAT          241..>322
FT                   /note="Solcar 3"
FT   NON_TER         322
SQ   SEQUENCE   322 AA;  35056 MW;  F78CBDA36CA9DC9A CRC64;
     MAALVAAAAL AAAEPPPAVP AAAGSGGPTS RRDFYWLRSF LAGSIAGCCA KTTVAPLDRV
     KVLLQAHNHH YKHLGVLSPL RAVPQKEGYL GLYKGNGAMM IRIFPYGAIQ FMAFEHYKTF
     ITTKLGVSGH VHRLMAGSMA GKMSMTAVIC TYPLDVVRVR LAFQVKGEHT YSGIIHAFKT
     IYAKEGGFLG FYRGLMPTIL GMAPYASVSF FTFGTLKSVG LSYAPTLLGR PSSDNPNVLV
     LKTHINLLCG GVARAIAQTI SYPFDVTRRR MQLGAVLPEF EKCLTMRETM KYVYGHHGIR
     RGLYRGLSLN YIRCIPSQAV AF