GDF1_MOUSE
ID GDF1_MOUSE Reviewed; 357 AA.
AC P20863; Q6AXH1;
DT 01-FEB-1991, integrated into UniProtKB/Swiss-Prot.
DT 27-JUL-2011, sequence version 2.
DT 03-AUG-2022, entry version 160.
DE RecName: Full=Embryonic growth/differentiation factor 1;
DE Short=GDF-1;
DE Flags: Precursor;
GN Name=Gdf1; Synonyms=Gdf-1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=1704486; DOI=10.1210/mend-4-7-1034;
RA Lee S.-J.;
RT "Identification of a novel member (GDF-1) of the transforming growth
RT factor-beta superfamily.";
RL Mol. Endocrinol. 4:1034-1040(1990).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=2034669; DOI=10.1073/pnas.88.10.4250;
RA Lee S.-J.;
RT "Expression of growth/differentiation factor 1 in the nervous system:
RT conservation of a bicistronic structure.";
RL Proc. Natl. Acad. Sci. U.S.A. 88:4250-4254(1991).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May mediate cell differentiation events during embryonic
CC development.
CC -!- SUBUNIT: Homodimer; disulfide-linked. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- TISSUE SPECIFICITY: Expressed almost exclusively in the nervous system.
CC -!- MISCELLANEOUS: This protein is produced by a bicistronic gene which
CC also produces the CERS1 protein from a non-overlapping reading frame.
CC -!- SIMILARITY: Belongs to the TGF-beta family. {ECO:0000305}.
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DR EMBL; M57639; AAA37674.1; -; mRNA.
DR EMBL; M62301; AAA37676.1; -; mRNA.
DR EMBL; BC079555; AAH79555.1; -; mRNA.
DR CCDS; CCDS52571.1; -.
DR PIR; A39364; A39364.
DR RefSeq; NP_001156754.1; NM_001163282.2.
DR RefSeq; NP_032133.2; NM_008107.4.
DR AlphaFoldDB; P20863; -.
DR SMR; P20863; -.
DR STRING; 10090.ENSMUSP00000045892; -.
DR GlyGen; P20863; 1 site.
DR PhosphoSitePlus; P20863; -.
DR PaxDb; P20863; -.
DR PRIDE; P20863; -.
DR DNASU; 14559; -.
DR Ensembl; ENSMUST00000165819; ENSMUSP00000128325; ENSMUSG00000087408.
DR Ensembl; ENSMUST00000207684; ENSMUSP00000146749; ENSMUSG00000109523.
DR GeneID; 14559; -.
DR KEGG; mmu:14559; -.
DR UCSC; uc009lzz.4; mouse.
DR CTD; 2657; -.
DR MGI; MGI:95683; Gdf1.
DR VEuPathDB; HostDB:ENSMUSG00000087408; -.
DR VEuPathDB; HostDB:ENSMUSG00000109523; -.
DR eggNOG; KOG3900; Eukaryota.
DR GeneTree; ENSGT00940000162926; -.
DR HOGENOM; CLU_020515_4_0_1; -.
DR InParanoid; P20863; -.
DR OMA; LMWRLFR; -.
DR OrthoDB; 1106226at2759; -.
DR PhylomeDB; P20863; -.
DR TreeFam; TF351789; -.
DR BioGRID-ORCS; 14559; 3 hits in 26 CRISPR screens.
DR ChiTaRS; Gdf1; mouse.
DR PRO; PR:P20863; -.
DR Proteomes; UP000000589; Chromosome 8.
DR RNAct; P20863; protein.
DR Bgee; ENSMUSG00000087408; Expressed in striatum and 44 other tissues.
DR ExpressionAtlas; P20863; baseline and differential.
DR Genevisible; P20863; MM.
DR GO; GO:0005576; C:extracellular region; TAS:Reactome.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0005125; F:cytokine activity; IBA:GO_Central.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR GO; GO:0030509; P:BMP signaling pathway; IBA:GO_Central.
DR GO; GO:0007492; P:endoderm development; IGI:MGI.
DR GO; GO:0001701; P:in utero embryonic development; IMP:MGI.
DR GO; GO:0007498; P:mesoderm development; IGI:MGI.
DR GO; GO:0010862; P:positive regulation of pathway-restricted SMAD protein phosphorylation; IBA:GO_Central.
DR GO; GO:0007165; P:signal transduction; IMP:MGI.
DR GO; GO:0060395; P:SMAD protein signal transduction; IBA:GO_Central.
DR Gene3D; 2.10.90.10; -; 1.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR001839; TGF-b_C.
DR InterPro; IPR015615; TGF-beta-rel.
DR InterPro; IPR017948; TGFb_CS.
DR PANTHER; PTHR11848; PTHR11848; 1.
DR Pfam; PF00019; TGF_beta; 1.
DR SMART; SM00204; TGFB; 1.
DR SUPFAM; SSF57501; SSF57501; 1.
DR PROSITE; PS00250; TGF_BETA_1; 1.
DR PROSITE; PS51362; TGF_BETA_2; 1.
PE 2: Evidence at transcript level;
KW Cleavage on pair of basic residues; Cytokine; Disulfide bond; Glycoprotein;
KW Growth factor; Reference proteome; Secreted; Signal.
FT SIGNAL 1..23
FT /evidence="ECO:0000255"
FT PROPEP 24..237
FT /evidence="ECO:0000255"
FT /id="PRO_0000033900"
FT CHAIN 238..357
FT /note="Embryonic growth/differentiation factor 1"
FT /id="PRO_0000033901"
FT CARBOHYD 191
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 251..322
FT /evidence="ECO:0000250"
FT DISULFID 280..354
FT /evidence="ECO:0000250"
FT DISULFID 284..356
FT /evidence="ECO:0000250"
FT DISULFID 321
FT /note="Interchain"
FT /evidence="ECO:0000250"
FT CONFLICT 145
FT /note="S -> C (in Ref. 1; AAA37674)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 357 AA; 38660 MW; CF3EA5056F9D6A49 CRC64;
MLPVCHRFCD HLLLLLLLPS TTLAPAPASM GPAAALLQVL GLPEAPRSVP THRPVPPVMW
RLFRRRDPQE ARVGRPLRPC HVEELGVAGN IVRHIPDSGL SSRPAQPART SGLCPEWTVV
FDLSNVEPTE RPTRARLELR LEAESEDTGG WELSVALWAD AEHPGPELLR VPAPPGVLLR
ADLLGTAVAA NASVPCTVRL ALSLHPGATA ACGRLAEASL LLVTLDPRLC PLPRLRRHTE
PRVEVGPVGT CRTRRLHVSF REVGWHRWVI APRGFLANFC QGTCALPETL RGPGGPPALN
HAVLRALMHA AAPTPGAGSP CCVPERLSPI SVLFFDNSDN VVLRHYEDMV VDECGCR
