GDF6B_DANRE
ID GDF6B_DANRE Reviewed; 412 AA.
AC A8E7N9; O12938;
DT 01-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT 13-NOV-2007, sequence version 1.
DT 03-AUG-2022, entry version 86.
DE RecName: Full=Growth/differentiation factor 6-B;
DE Short=GDF-6-B;
DE AltName: Full=Growth differentiation factor 6b;
DE AltName: Full=Protein dynamo;
DE Flags: Precursor;
GN Name=gdf6b {ECO:0000312|ZFIN:ZDB-GENE-980526-442};
GN Synonyms=dynamo {ECO:0000312|EMBL:CAA68102.1}; ORFNames=si:ch211-244a23.2;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1] {ECO:0000305, ECO:0000312|EMBL:CAA68102.1}
RP NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND INDUCTION.
RC TISSUE=Embryo {ECO:0000312|EMBL:CAA68102.1};
RX PubMed=9076689; DOI=10.1016/s0925-4773(96)00641-7;
RA Bruneau S., Rosa F.M.;
RT "Dynamo, a new zebrafish DVR member of the TGF-beta superfamily is
RT expressed in the posterior neural tube and is up-regulated by Sonic
RT hedgehog.";
RL Mech. Dev. 61:199-212(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen;
RX PubMed=23594743; DOI=10.1038/nature12111;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
CC -!- SUBUNIT: Homodimer; disulfide-linked. {ECO:0000250|UniProtKB:P39905}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Expression is correlated temporally and spatially
CC with somitogenesis. At late gastrula stage, expressed in the posterior
CC presumptive neural plate. During somitogenesis, expression becomes
CC restricted along the dorsoventral axis of the trunk neural tube in an
CC anterior-to-posterior progression so that upon completion of
CC somitogenesis, expression is seen exclusively in the ventral spinal
CC cord with the exclusion of the floor plate and adjacent neural cells.
CC {ECO:0000269|PubMed:9076689}.
CC -!- INDUCTION: By shh. {ECO:0000269|PubMed:9076689}.
CC -!- SIMILARITY: Belongs to the TGF-beta family. {ECO:0000255}.
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DR EMBL; X99769; CAA68102.1; -; mRNA.
DR EMBL; BX649562; CAP09513.1; -; Genomic_DNA.
DR EMBL; BX571825; CAP09513.1; JOINED; Genomic_DNA.
DR EMBL; BX571825; CAP09561.1; -; Genomic_DNA.
DR EMBL; BX649562; CAP09561.1; JOINED; Genomic_DNA.
DR RefSeq; NP_571062.1; NM_130987.1.
DR AlphaFoldDB; A8E7N9; -.
DR SMR; A8E7N9; -.
DR STRING; 7955.ENSDARP00000126187; -.
DR PaxDb; A8E7N9; -.
DR Ensembl; ENSDART00000151090; ENSDARP00000126187; ENSDARG00000005510.
DR GeneID; 30180; -.
DR KEGG; dre:30180; -.
DR CTD; 30180; -.
DR ZFIN; ZDB-GENE-980526-442; gdf6b.
DR eggNOG; KOG3900; Eukaryota.
DR GeneTree; ENSGT00940000160140; -.
DR InParanoid; A8E7N9; -.
DR OMA; HRPKWEV; -.
DR OrthoDB; 749511at2759; -.
DR PhylomeDB; A8E7N9; -.
DR TreeFam; TF316134; -.
DR PRO; PR:A8E7N9; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 19.
DR Bgee; ENSDARG00000005510; Expressed in camera-type eye and 2 other tissues.
DR ExpressionAtlas; A8E7N9; baseline.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0005125; F:cytokine activity; IBA:GO_Central.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR GO; GO:0010862; P:positive regulation of pathway-restricted SMAD protein phosphorylation; IBA:GO_Central.
DR GO; GO:0060395; P:SMAD protein signal transduction; IBA:GO_Central.
DR Gene3D; 2.10.90.10; -; 1.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR001839; TGF-b_C.
DR InterPro; IPR001111; TGF-b_propeptide.
DR InterPro; IPR015615; TGF-beta-rel.
DR InterPro; IPR017948; TGFb_CS.
DR PANTHER; PTHR11848; PTHR11848; 1.
DR Pfam; PF00019; TGF_beta; 1.
DR Pfam; PF00688; TGFb_propeptide; 1.
DR SMART; SM00204; TGFB; 1.
DR SUPFAM; SSF57501; SSF57501; 1.
DR PROSITE; PS00250; TGF_BETA_1; 1.
DR PROSITE; PS51362; TGF_BETA_2; 1.
PE 2: Evidence at transcript level;
KW Cleavage on pair of basic residues; Disulfide bond; Glycoprotein;
KW Growth factor; Reference proteome; Secreted; Signal.
FT SIGNAL 1..21
FT /evidence="ECO:0000255"
FT PROPEP 22..287
FT /evidence="ECO:0000255"
FT /id="PRO_0000342705"
FT CHAIN 293..412
FT /note="Growth/differentiation factor 6-B"
FT /evidence="ECO:0000255"
FT /id="PRO_5000146904"
FT REGION 280..311
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 283..311
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 95
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 311..377
FT /evidence="ECO:0000250|UniProtKB:P39905"
FT DISULFID 340..409
FT /evidence="ECO:0000250|UniProtKB:P39905"
FT DISULFID 344..411
FT /evidence="ECO:0000250|UniProtKB:P39905"
FT DISULFID 376
FT /note="Interchain"
FT /evidence="ECO:0000250|UniProtKB:P39905"
FT CONFLICT 20
FT /note="H -> Q (in Ref. 1; CAA68102)"
FT /evidence="ECO:0000305"
FT CONFLICT 212
FT /note="T -> N (in Ref. 1; CAA68102)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 412 AA; 47068 MW; 984B6CE085B0001B CRC64;
MCACGILLTF TLLLHFLGVH SMNPLFPSAS RGMKVSKSVP AEGNRRAKYG KNVLSASLLS
GDIQSRRAIK DAIEPHDYMI SIYKTFSAAE KLGLNASFFR SSKAANTITS FVDEGQDDHL
NSPLWRQKYL FDVSTLSENV EILGAELRIY TKISGSFRAS ETGPVEIQLL SCQSHTVLDS
QTLDLEDAHK PKWEVFDVWE IFKERQHHSH GTRFCLELRA TLDNPEREID LQYLGFHRHG
RPQLKKAILV VFTRSKKRQS LFYEKREKIK LWGLDSIGKE RRSHSKTRRS RRTALPNRHG
KRHGKKSKSR CSKKPLHVNF RELGWDDWVI APLDYEAYHC EGMCDFPLRS HLEPTNHAII
QTLMNSMNPS NMPPSCCVPS KLSPISILYI DAGNNVVYKQ YEDMVVESCG CR
