GDF7_CHLAE
ID GDF7_CHLAE Reviewed; 447 AA.
AC Q9BDW8;
DT 19-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 25-MAY-2022, entry version 61.
DE RecName: Full=Growth/differentiation factor 7;
DE Short=GDF-7;
DE Flags: Precursor;
GN Name=GDF7;
OS Chlorocebus aethiops (Green monkey) (Cercopithecus aethiops).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Chlorocebus.
OX NCBI_TaxID=9534;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND TISSUE SPECIFICITY.
RX PubMed=11238730; DOI=10.1046/j.1471-4159.2001.00177.x;
RA Watakabe A., Fujita H., Hayashi M., Yamamori T.;
RT "Growth/differentiation factor 7 is preferentially expressed in the primary
RT motor area of the monkey neocortex.";
RL J. Neurochem. 76:1455-1464(2001).
CC -!- FUNCTION: May play an active role in the motor area of the primate
CC neocortex.
CC -!- SUBUNIT: Homodimer; disulfide-linked. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Highly expressed in the primary aera of brain
CC neocortex. {ECO:0000269|PubMed:11238730}.
CC -!- SIMILARITY: Belongs to the TGF-beta family. {ECO:0000305}.
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DR EMBL; AF254569; AAK30842.1; -; Genomic_DNA.
DR EMBL; AF254568; AAK30842.1; JOINED; Genomic_DNA.
DR AlphaFoldDB; Q9BDW8; -.
DR SMR; Q9BDW8; -.
DR GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR Gene3D; 2.10.90.10; -; 1.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR001839; TGF-b_C.
DR InterPro; IPR001111; TGF-b_propeptide.
DR InterPro; IPR015615; TGF-beta-rel.
DR InterPro; IPR017948; TGFb_CS.
DR PANTHER; PTHR11848; PTHR11848; 1.
DR Pfam; PF00019; TGF_beta; 1.
DR Pfam; PF00688; TGFb_propeptide; 1.
DR SMART; SM00204; TGFB; 1.
DR SUPFAM; SSF57501; SSF57501; 1.
DR PROSITE; PS00250; TGF_BETA_1; 1.
DR PROSITE; PS51362; TGF_BETA_2; 1.
PE 2: Evidence at transcript level;
KW Cleavage on pair of basic residues; Cytokine; Disulfide bond; Glycoprotein;
KW Growth factor; Secreted; Signal.
FT SIGNAL 1..19
FT /evidence="ECO:0000255"
FT PROPEP 20..318
FT /evidence="ECO:0000255"
FT /id="PRO_0000033920"
FT CHAIN 319..447
FT /note="Growth/differentiation factor 7"
FT /id="PRO_0000033921"
FT REGION 292..346
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 80
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 346..412
FT /evidence="ECO:0000250"
FT DISULFID 375..444
FT /evidence="ECO:0000250"
FT DISULFID 379..446
FT /evidence="ECO:0000250"
FT DISULFID 411
FT /note="Interchain"
FT /evidence="ECO:0000250"
SQ SEQUENCE 447 AA; 46866 MW; DF46D591925A8391 CRC64;
MDLSAAAALC LWLLSACRPR DGLEAAAVLR AAGAGPVRSP GGGGGGGRTL AQAAGAAAVP
AAAVSRARAP RRAAGSGFRN GSVVPHHFMM SLYRSLAGRA PAGAVAVSSS GHGRADTITG
FTDQATQDES AAETGQSFLF DVSSLNDADE VVGAELRVLR RGSPEPGPGS STSPPLLLLS
TCPGAARAPR LLYSRAAEPL VGQRWEVFDV ADAMRRHRRE PRPPRAFCLL LRAVTGPVRS
PLALRRLGFG WPGGGGSAPE ERALLVVSSR TQRKESLFRE MRAQARALGA ALAAQPPPDP
GTGTGSPRAV TAGRRRRRTA LAGTRTAQGS GGGAGRGHGR RGRSRCSRKP LHVDFKELGW
DDWIIAPLDY EAYHCEGVCD FPLRSHLEPT NHAIIQTLLN SMAPDAAPAS CCVPARLSPI
SILYIDAANN VVYKQYEDMV VEACGCR