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GDF7_CHLAE
ID   GDF7_CHLAE              Reviewed;         447 AA.
AC   Q9BDW8;
DT   19-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   25-MAY-2022, entry version 61.
DE   RecName: Full=Growth/differentiation factor 7;
DE            Short=GDF-7;
DE   Flags: Precursor;
GN   Name=GDF7;
OS   Chlorocebus aethiops (Green monkey) (Cercopithecus aethiops).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Chlorocebus.
OX   NCBI_TaxID=9534;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND TISSUE SPECIFICITY.
RX   PubMed=11238730; DOI=10.1046/j.1471-4159.2001.00177.x;
RA   Watakabe A., Fujita H., Hayashi M., Yamamori T.;
RT   "Growth/differentiation factor 7 is preferentially expressed in the primary
RT   motor area of the monkey neocortex.";
RL   J. Neurochem. 76:1455-1464(2001).
CC   -!- FUNCTION: May play an active role in the motor area of the primate
CC       neocortex.
CC   -!- SUBUNIT: Homodimer; disulfide-linked. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Highly expressed in the primary aera of brain
CC       neocortex. {ECO:0000269|PubMed:11238730}.
CC   -!- SIMILARITY: Belongs to the TGF-beta family. {ECO:0000305}.
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DR   EMBL; AF254569; AAK30842.1; -; Genomic_DNA.
DR   EMBL; AF254568; AAK30842.1; JOINED; Genomic_DNA.
DR   AlphaFoldDB; Q9BDW8; -.
DR   SMR; Q9BDW8; -.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW.
DR   GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR   Gene3D; 2.10.90.10; -; 1.
DR   InterPro; IPR029034; Cystine-knot_cytokine.
DR   InterPro; IPR001839; TGF-b_C.
DR   InterPro; IPR001111; TGF-b_propeptide.
DR   InterPro; IPR015615; TGF-beta-rel.
DR   InterPro; IPR017948; TGFb_CS.
DR   PANTHER; PTHR11848; PTHR11848; 1.
DR   Pfam; PF00019; TGF_beta; 1.
DR   Pfam; PF00688; TGFb_propeptide; 1.
DR   SMART; SM00204; TGFB; 1.
DR   SUPFAM; SSF57501; SSF57501; 1.
DR   PROSITE; PS00250; TGF_BETA_1; 1.
DR   PROSITE; PS51362; TGF_BETA_2; 1.
PE   2: Evidence at transcript level;
KW   Cleavage on pair of basic residues; Cytokine; Disulfide bond; Glycoprotein;
KW   Growth factor; Secreted; Signal.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255"
FT   PROPEP          20..318
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000033920"
FT   CHAIN           319..447
FT                   /note="Growth/differentiation factor 7"
FT                   /id="PRO_0000033921"
FT   REGION          292..346
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        80
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        346..412
FT                   /evidence="ECO:0000250"
FT   DISULFID        375..444
FT                   /evidence="ECO:0000250"
FT   DISULFID        379..446
FT                   /evidence="ECO:0000250"
FT   DISULFID        411
FT                   /note="Interchain"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   447 AA;  46866 MW;  DF46D591925A8391 CRC64;
     MDLSAAAALC LWLLSACRPR DGLEAAAVLR AAGAGPVRSP GGGGGGGRTL AQAAGAAAVP
     AAAVSRARAP RRAAGSGFRN GSVVPHHFMM SLYRSLAGRA PAGAVAVSSS GHGRADTITG
     FTDQATQDES AAETGQSFLF DVSSLNDADE VVGAELRVLR RGSPEPGPGS STSPPLLLLS
     TCPGAARAPR LLYSRAAEPL VGQRWEVFDV ADAMRRHRRE PRPPRAFCLL LRAVTGPVRS
     PLALRRLGFG WPGGGGSAPE ERALLVVSSR TQRKESLFRE MRAQARALGA ALAAQPPPDP
     GTGTGSPRAV TAGRRRRRTA LAGTRTAQGS GGGAGRGHGR RGRSRCSRKP LHVDFKELGW
     DDWIIAPLDY EAYHCEGVCD FPLRSHLEPT NHAIIQTLLN SMAPDAAPAS CCVPARLSPI
     SILYIDAANN VVYKQYEDMV VEACGCR
 
 
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