GDF7_MOUSE
ID GDF7_MOUSE Reviewed; 461 AA.
AC P43029; Q7TNX4; Q99MY1;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 19-JUL-2004, sequence version 2.
DT 03-AUG-2022, entry version 151.
DE RecName: Full=Growth/differentiation factor 7;
DE Short=GDF-7;
DE Flags: Precursor;
GN Name=Gdf7; Synonyms=Gdf-7;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=BALB/cJ; TISSUE=Testis;
RA Guo J.H., Yu L.;
RL Submitted (JUN-2002) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-441 (ISOFORM 1).
RC STRAIN=TT2;
RX PubMed=11238730; DOI=10.1046/j.1471-4159.2001.00177.x;
RA Watakabe A., Fujita H., Hayashi M., Yamamori T.;
RT "Growth/differentiation factor 7 is preferentially expressed in the primary
RT motor area of the monkey neocortex.";
RL J. Neurochem. 76:1455-1464(2001).
RN [3]
RP NUCLEOTIDE SEQUENCE OF 311-461.
RC STRAIN=BALB/cJ; TISSUE=Liver;
RX PubMed=8145850; DOI=10.1038/368639a0;
RA Storm E.E., Huynh T.V., Copeland N.G., Jenkins N.A., Kingsley D.M.,
RA Lee S.-J.;
RT "Limb alterations in brachypodism mice due to mutations in a new member of
RT the TGF beta-superfamily.";
RL Nature 368:639-643(1994).
CC -!- SUBUNIT: Homodimer; disulfide-linked. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=P43029-1; Sequence=Displayed;
CC Name=2;
CC IsoId=P43029-2; Sequence=VSP_010764;
CC -!- SIMILARITY: Belongs to the TGF-beta family. {ECO:0000305}.
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DR EMBL; AF525752; AAP97721.1; -; mRNA.
DR EMBL; AH010605; AAK30843.1; -; Genomic_DNA.
DR EMBL; U08339; AAA18780.1; -; Unassigned_DNA.
DR CCDS; CCDS83954.1; -. [P43029-1]
DR CCDS; CCDS88308.1; -. [P43029-2]
DR PIR; S43296; S43296.
DR RefSeq; NP_001299805.1; NM_001312876.1. [P43029-1]
DR RefSeq; NP_038555.1; NM_013527.1. [P43029-2]
DR AlphaFoldDB; P43029; -.
DR BioGRID; 231945; 1.
DR IntAct; P43029; 1.
DR STRING; 10090.ENSMUSP00000038301; -.
DR GlyGen; P43029; 1 site.
DR PhosphoSitePlus; P43029; -.
DR PaxDb; P43029; -.
DR PeptideAtlas; P43029; -.
DR PRIDE; P43029; -.
DR ProteomicsDB; 273040; -. [P43029-1]
DR ProteomicsDB; 273041; -. [P43029-2]
DR Antibodypedia; 27314; 266 antibodies from 28 providers.
DR DNASU; 238057; -.
DR Ensembl; ENSMUST00000037313; ENSMUSP00000038301; ENSMUSG00000037660. [P43029-1]
DR Ensembl; ENSMUST00000220073; ENSMUSP00000151234; ENSMUSG00000037660. [P43029-2]
DR GeneID; 238057; -.
DR KEGG; mmu:238057; -.
DR UCSC; uc007mzl.1; mouse. [P43029-2]
DR CTD; 151449; -.
DR MGI; MGI:95690; Gdf7.
DR VEuPathDB; HostDB:ENSMUSG00000037660; -.
DR eggNOG; KOG3900; Eukaryota.
DR GeneTree; ENSGT00940000160140; -.
DR HOGENOM; CLU_020515_0_1_1; -.
DR InParanoid; P43029; -.
DR OMA; GARWEVF; -.
DR OrthoDB; 749511at2759; -.
DR PhylomeDB; P43029; -.
DR TreeFam; TF316134; -.
DR BioGRID-ORCS; 238057; 1 hit in 65 CRISPR screens.
DR PRO; PR:P43029; -.
DR Proteomes; UP000000589; Chromosome 12.
DR RNAct; P43029; protein.
DR Bgee; ENSMUSG00000037660; Expressed in uterus and 18 other tissues.
DR GO; GO:0005576; C:extracellular region; IDA:MGI.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0005125; F:cytokine activity; IBA:GO_Central.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR GO; GO:0042802; F:identical protein binding; IPI:MGI.
DR GO; GO:0032924; P:activin receptor signaling pathway; ISO:MGI.
DR GO; GO:0007411; P:axon guidance; IDA:MGI.
DR GO; GO:0030509; P:BMP signaling pathway; IDA:MGI.
DR GO; GO:0048754; P:branching morphogenesis of an epithelial tube; IMP:MGI.
DR GO; GO:0045165; P:cell fate commitment; IDA:MGI.
DR GO; GO:0030855; P:epithelial cell differentiation; IMP:MGI.
DR GO; GO:0048853; P:forebrain morphogenesis; IMP:MGI.
DR GO; GO:0022612; P:gland morphogenesis; IMP:MGI.
DR GO; GO:0030901; P:midbrain development; IMP:MGI.
DR GO; GO:0060571; P:morphogenesis of an epithelial fold; IMP:MGI.
DR GO; GO:0021915; P:neural tube development; IMP:MGI.
DR GO; GO:0060389; P:pathway-restricted SMAD protein phosphorylation; ISO:MGI.
DR GO; GO:0010628; P:positive regulation of gene expression; IDA:UniProtKB.
DR GO; GO:0045666; P:positive regulation of neuron differentiation; IDA:MGI.
DR GO; GO:0010862; P:positive regulation of pathway-restricted SMAD protein phosphorylation; ISO:MGI.
DR GO; GO:2001051; P:positive regulation of tendon cell differentiation; IDA:UniProtKB.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; ISO:MGI.
DR GO; GO:0048608; P:reproductive structure development; IMP:MGI.
DR GO; GO:0021509; P:roof plate formation; IMP:MGI.
DR GO; GO:0060395; P:SMAD protein signal transduction; IBA:GO_Central.
DR GO; GO:0021527; P:spinal cord association neuron differentiation; IMP:MGI.
DR Gene3D; 2.10.90.10; -; 1.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR001839; TGF-b_C.
DR InterPro; IPR001111; TGF-b_propeptide.
DR InterPro; IPR015615; TGF-beta-rel.
DR InterPro; IPR017948; TGFb_CS.
DR PANTHER; PTHR11848; PTHR11848; 1.
DR Pfam; PF00019; TGF_beta; 1.
DR Pfam; PF00688; TGFb_propeptide; 1.
DR SMART; SM00204; TGFB; 1.
DR SUPFAM; SSF57501; SSF57501; 1.
DR PROSITE; PS00250; TGF_BETA_1; 1.
DR PROSITE; PS51362; TGF_BETA_2; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Cleavage on pair of basic residues; Cytokine;
KW Disulfide bond; Glycoprotein; Growth factor; Reference proteome; Secreted;
KW Signal.
FT SIGNAL 1..19
FT /evidence="ECO:0000255"
FT PROPEP 20..315
FT /evidence="ECO:0000255"
FT /id="PRO_0000033924"
FT CHAIN 316..461
FT /note="Growth/differentiation factor 7"
FT /id="PRO_0000033925"
FT REGION 287..360
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 79
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 360..426
FT /evidence="ECO:0000250"
FT DISULFID 389..458
FT /evidence="ECO:0000250"
FT DISULFID 393..460
FT /evidence="ECO:0000250"
FT DISULFID 425
FT /note="Interchain"
FT /evidence="ECO:0000250"
FT VAR_SEQ 123..130
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|Ref.1"
FT /id="VSP_010764"
SQ SEQUENCE 461 AA; 47891 MW; 92C2511C86EDE478 CRC64;
MDLSAAAALC LWLLSACRPR DGLEAAAVLR AAGAGPAWSP GGGGGGRTLA RAPGPSALQA
AAVPGPRAVR RAAGSGFRNG SVVPHHFMMS LYRSLAGRAP VAAASGHGRV DTITGFTDQA
TQDETAAAEP GQSFLFDVSS LSEADEVVNA ELRVLRRRSP EPDRDSATLL PRLLLSTCPD
EAGTAHLLHS RAAEPLGGAR WEAFDVTDAV QSHRRWPRAS RKFCLVLRAV TASESSPLAL
RRLGFGWPGG GDGGGTAAEE RALLVISSRT QRKESLFREI RAQARALRAA AEPPPDPGPG
AGSRKANLGG RRRRRTALAG TRGAQGSGGG GGGGGGGGGG GGGGGGGAGR GHGRRGRSRC
SRKSLHVDFK ELGWDDWIIA PLDYEAYHCE GVCDFPLRSH LEPTNHAIIQ TLLNSMAPDA
APASCCVPAR LSPISILYID AANNVVYKQY EDMVVEACGC R
