GDF9_MOUSE
ID GDF9_MOUSE Reviewed; 441 AA.
AC Q07105;
DT 01-OCT-1994, integrated into UniProtKB/Swiss-Prot.
DT 23-NOV-2004, sequence version 2.
DT 03-AUG-2022, entry version 157.
DE RecName: Full=Growth/differentiation factor 9;
DE Short=GDF-9;
DE Flags: Precursor;
GN Name=Gdf9; Synonyms=Gdf-9;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=8429021; DOI=10.1016/s0021-9258(18)53714-5;
RA McPherron A.C., Lee S.-J.;
RT "GDF-3 and GDF-9: two new members of the transforming growth factor-beta
RT superfamily containing a novel pattern of cysteines.";
RL J. Biol. Chem. 268:3444-3449(1993).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=129/SvEv;
RX PubMed=8186260; DOI=10.1016/0167-4889(94)90034-5;
RA Incerti B., Dong J., Borsani G., Matzuk M.M.;
RT "Structure of the mouse growth/differentiation factor 9 gene.";
RL Biochim. Biophys. Acta 1222:125-128(1994).
RN [3]
RP SPECIES-SPECIFIC OVULATION RATE DETERMINATION.
RX PubMed=21970812; DOI=10.1016/j.mce.2011.09.033;
RA Crawford J.L., McNatty K.P.;
RT "The ratio of growth differentiation factor 9: bone morphogenetic protein
RT 15 mRNA expression is tightly co-regulated and differs between species over
RT a wide range of ovulation rates.";
RL Mol. Cell. Endocrinol. 348:339-343(2012).
CC -!- FUNCTION: Required for ovarian folliculogenesis.
CC -!- SUBUNIT: Homodimer or heterodimer (Potential). But, in contrast to
CC other members of this family, cannot be disulfide-linked.
CC {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Ovary.
CC -!- PTM: Phosphorylated; phosphorylation is critical for GDF9 function.
CC {ECO:0000250}.
CC -!- MISCELLANEOUS: Ovarian physiology and fertility are controlled by
CC endocrine and paracrine signals. These act in a species-dependent
CC manner and determine the ovulation quota in different mammalian
CC species. While humans, and mammals such as the cow or red deer,
CC normally ovulate only one egg per cycle, other mammals such as mouse
CC and pig can ovulate in excess of ten per cycle. The mechanisms that
CC regulate the species-specific differences in the number of follicles
CC that go onto ovulate during each reproductive cycle are poorly
CC understood. According to PubMed:21970812, mRNA expression levels of
CC GDF9 and BMP15 are tightly coregulated within each species and
CC influence species-specific ovulation-rates.
CC -!- SIMILARITY: Belongs to the TGF-beta family. {ECO:0000305}.
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DR EMBL; L06444; AAA53035.1; -; mRNA.
DR EMBL; X77112; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; X77113; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS24679.1; -.
DR PIR; S45284; S45284.
DR RefSeq; NP_032136.2; NM_008110.2.
DR AlphaFoldDB; Q07105; -.
DR IntAct; Q07105; 1.
DR STRING; 10090.ENSMUSP00000018382; -.
DR GlyGen; Q07105; 4 sites.
DR iPTMnet; Q07105; -.
DR PhosphoSitePlus; Q07105; -.
DR PaxDb; Q07105; -.
DR PRIDE; Q07105; -.
DR Antibodypedia; 26178; 566 antibodies from 31 providers.
DR DNASU; 14566; -.
DR Ensembl; ENSMUST00000018382; ENSMUSP00000018382; ENSMUSG00000018238.
DR GeneID; 14566; -.
DR KEGG; mmu:14566; -.
DR UCSC; uc007iwa.2; mouse.
DR CTD; 2661; -.
DR MGI; MGI:95692; Gdf9.
DR VEuPathDB; HostDB:ENSMUSG00000018238; -.
DR eggNOG; KOG3900; Eukaryota.
DR GeneTree; ENSGT00940000159784; -.
DR HOGENOM; CLU_055377_1_0_1; -.
DR InParanoid; Q07105; -.
DR OMA; CAQHKQA; -.
DR OrthoDB; 724783at2759; -.
DR PhylomeDB; Q07105; -.
DR TreeFam; TF351788; -.
DR BioGRID-ORCS; 14566; 0 hits in 72 CRISPR screens.
DR ChiTaRS; Gdf9; mouse.
DR PRO; PR:Q07105; -.
DR Proteomes; UP000000589; Chromosome 11.
DR RNAct; Q07105; protein.
DR Bgee; ENSMUSG00000018238; Expressed in secondary oocyte and 68 other tissues.
DR ExpressionAtlas; Q07105; baseline and differential.
DR Genevisible; Q07105; MM.
DR GO; GO:0005737; C:cytoplasm; IDA:MGI.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0005125; F:cytokine activity; IBA:GO_Central.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR GO; GO:0070698; F:type I activin receptor binding; IBA:GO_Central.
DR GO; GO:0030509; P:BMP signaling pathway; IBA:GO_Central.
DR GO; GO:0030308; P:negative regulation of cell growth; IMP:MGI.
DR GO; GO:0001555; P:oocyte growth; IMP:MGI.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; ISO:MGI.
DR GO; GO:0010862; P:positive regulation of pathway-restricted SMAD protein phosphorylation; IBA:GO_Central.
DR GO; GO:2000870; P:regulation of progesterone secretion; ISO:MGI.
DR GO; GO:0060395; P:SMAD protein signal transduction; IBA:GO_Central.
DR Gene3D; 2.10.90.10; -; 1.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR015617; Growth_differentiation_fac-9.
DR InterPro; IPR001839; TGF-b_C.
DR InterPro; IPR015615; TGF-beta-rel.
DR InterPro; IPR017948; TGFb_CS.
DR PANTHER; PTHR11848; PTHR11848; 1.
DR PANTHER; PTHR11848:SF19; PTHR11848:SF19; 1.
DR Pfam; PF00019; TGF_beta; 1.
DR SMART; SM00204; TGFB; 1.
DR SUPFAM; SSF57501; SSF57501; 1.
DR PROSITE; PS00250; TGF_BETA_1; 1.
DR PROSITE; PS51362; TGF_BETA_2; 1.
PE 2: Evidence at transcript level;
KW Cleavage on pair of basic residues; Cytokine; Disulfide bond; Glycoprotein;
KW Growth factor; Phosphoprotein; Reference proteome; Secreted; Signal.
FT SIGNAL 1..29
FT /evidence="ECO:0000255"
FT PROPEP 30..306
FT /evidence="ECO:0000255"
FT /id="PRO_0000033982"
FT CHAIN 307..441
FT /note="Growth/differentiation factor 9"
FT /id="PRO_0000033983"
FT CARBOHYD 163
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 229
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 258
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 325
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 340..406
FT /evidence="ECO:0000250"
FT DISULFID 369..438
FT /evidence="ECO:0000250"
FT DISULFID 373..440
FT /evidence="ECO:0000250"
FT CONFLICT 296
FT /note="I -> T (in Ref. 1; AAA53035)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 441 AA; 49649 MW; 43B47ADD41B99C29 CRC64;
MALPSNFLLG VCCFAWLCFL SSLSSQASTE ESQSGASENV ESEADPWSLL LPVDGTDRSG
LLPPLFKVLS DRRGETPKLQ PDSRALYYMK KLYKTYATKE GVPKPSRSHL YNTVRLFSPC
AQQEQAPSNQ VTGPLPMVDL LFNLDRVTAM EHLLKSVLLY TLNNSASSSS TVTCMCDLVV
KEAMSSGRAP PRAPYSFTLK KHRWIEIDVT SLLQPLVTSS ERSIHLSVNF TCTKDQVPED
GVFSMPLSVP PSLILYLNDT STQAYHSWQS LQSTWRPLQH PGQAGVAARP VKEEAIEVER
SPRRRRGQKA IRSEAKGPLL TASFNLSEYF KQFLFPQNEC ELHDFRLSFS QLKWDNWIVA
PHRYNPRYCK GDCPRAVRHR YGSPVHTMVQ NIIYEKLDPS VPRPSCVPGK YSPLSVLTIE
PDGSIAYKEY EDMIATRCTC R
