GDI2_ARATH
ID GDI2_ARATH Reviewed; 444 AA.
AC O24653;
DT 19-MAR-2014, integrated into UniProtKB/Swiss-Prot.
DT 01-JAN-1998, sequence version 1.
DT 25-MAY-2022, entry version 137.
DE RecName: Full=Guanosine nucleotide diphosphate dissociation inhibitor 2;
DE Short=AtGDI2;
GN Name=GDI2; OrderedLocusNames=At3g59920; ORFNames=F24G16.190;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=7846151; DOI=10.1104/pp.106.4.1241;
RA Newman T., de Bruijn F.J., Green P., Keegstra K., Kende H., Mclntosh L.,
RA Ohlrogge J., Raikhel N., Somerville S., Thomashow M., Retzel E.,
RA Somerville C.;
RT "Genes galore: a summary of methods for accessing results from large-scale
RT partial sequencing of anonymous Arabidopsis cDNA clones.";
RL Plant Physiol. 106:1241-1255(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND TISSUE SPECIFICITY.
RX PubMed=9461425; DOI=10.1016/s0378-1119(97)00584-2;
RA Ueda T., Yoshizumi T., Anai T., Matsui M., Uchimiya H., Nakano A.;
RT "AtGDI2, a novel Arabidopsis gene encoding a Rab GDP dissociation
RT inhibitor.";
RL Gene 206:137-143(1998).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130713; DOI=10.1038/35048706;
RA Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B.,
RA Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M.,
RA Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V.,
RA Choisne N., Artiguenave F., Robert C., Brottier P., Wincker P.,
RA Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H.,
RA Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H.,
RA Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A.,
RA Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H.,
RA Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J.,
RA Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B.,
RA Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D.,
RA de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E.,
RA Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G.,
RA Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X.,
RA Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M.,
RA Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B.,
RA Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J.,
RA Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C.,
RA Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y.,
RA Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K.,
RA Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A.,
RA Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T.,
RA Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana.";
RL Nature 408:820-822(2000).
RN [4]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
CC -!- FUNCTION: Regulates the GDP/GTP exchange reaction of most RAB proteins
CC by inhibiting the dissociation of GDP from them, and the subsequent
CC binding of GTP. {ECO:0000269|PubMed:9461425}.
CC -!- TISSUE SPECIFICITY: Expressed in roots and floral buds.
CC {ECO:0000269|PubMed:9461425}.
CC -!- SIMILARITY: Belongs to the Rab GDI family. {ECO:0000305}.
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DR EMBL; AJ001397; CAA04727.1; -; mRNA.
DR EMBL; AB005560; BAA22504.1; -; mRNA.
DR EMBL; AL138647; CAB75811.1; -; Genomic_DNA.
DR EMBL; CP002686; AEE79985.1; -; Genomic_DNA.
DR EMBL; AY081269; AAL91158.1; -; mRNA.
DR EMBL; BT000011; AAN15330.1; -; mRNA.
DR PIR; T47816; T47816.
DR RefSeq; NP_191551.1; NM_115855.4.
DR AlphaFoldDB; O24653; -.
DR SMR; O24653; -.
DR BioGRID; 10476; 4.
DR IntAct; O24653; 3.
DR STRING; 3702.AT3G59920.1; -.
DR iPTMnet; O24653; -.
DR PaxDb; O24653; -.
DR PRIDE; O24653; -.
DR ProteomicsDB; 224746; -.
DR EnsemblPlants; AT3G59920.1; AT3G59920.1; AT3G59920.
DR GeneID; 825162; -.
DR Gramene; AT3G59920.1; AT3G59920.1; AT3G59920.
DR KEGG; ath:AT3G59920; -.
DR Araport; AT3G59920; -.
DR TAIR; locus:2080527; AT3G59920.
DR eggNOG; KOG1439; Eukaryota.
DR HOGENOM; CLU_021695_0_0_1; -.
DR InParanoid; O24653; -.
DR OMA; LVIRVIC; -.
DR OrthoDB; 763627at2759; -.
DR PhylomeDB; O24653; -.
DR PRO; PR:O24653; -.
DR Proteomes; UP000006548; Chromosome 3.
DR ExpressionAtlas; O24653; baseline and differential.
DR Genevisible; O24653; AT.
DR GO; GO:0048046; C:apoplast; IDA:TAIR.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005829; C:cytosol; HDA:TAIR.
DR GO; GO:0009506; C:plasmodesma; HDA:TAIR.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0005093; F:Rab GDP-dissociation inhibitor activity; IGI:UniProtKB.
DR GO; GO:0015031; P:protein transport; IEA:InterPro.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR GO; GO:0016192; P:vesicle-mediated transport; IBA:GO_Central.
DR Gene3D; 3.50.50.60; -; 1.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR018203; GDP_dissociation_inhibitor.
DR InterPro; IPR000806; RabGDI.
DR PANTHER; PTHR11787; PTHR11787; 1.
DR Pfam; PF00996; GDI; 1.
DR PRINTS; PR00892; RABGDI.
DR PRINTS; PR00891; RABGDIREP.
DR SUPFAM; SSF51905; SSF51905; 2.
PE 2: Evidence at transcript level;
KW GTPase activation; Reference proteome.
FT CHAIN 1..444
FT /note="Guanosine nucleotide diphosphate dissociation
FT inhibitor 2"
FT /id="PRO_0000425808"
SQ SEQUENCE 444 AA; 49539 MW; 74DCD785558D9097 CRC64;
MDEEYEVIVL GTGLKECILS GLLSVDGVKV LHMDRNDYYG GESTSLNLNQ LWKKFRGEEK
APEHLGASRD YNVDMMPKFM MGNGKLVRTL IHTDVTKYLS FKAVDGSYVF VKGKVQKVPA
TPMEALKSSL MGIFEKRRAG KFFSFVQEYD EKDPKTHDGM DLTRVTTKEL IAKYGLDGNT
IDFIGHAVAL HTNDQHLDQP AFDTVMRMKL YAESLARFQG TSPYIYPLYG LGELPQAFAR
LSAVYGGTYM LNKPECKVEF DEGGKVIGVT SEGETAKCKK IVCDPSYLPN KVRKIGRVAR
AIAIMSHPIP NTNDSHSVQV IIPQKQLARK SDMYVFCCSY SHNVAPKGKF IAFVSTDAET
DNPQTELKPG TDLLGPVDEI FFDMYDRYEP VNEPELDNCF ISTSYDATTH FETTVADVLN
MYTLITGKQL DLSVDLSAAS AAEE
