GDIA_PANTR
ID GDIA_PANTR Reviewed; 447 AA.
AC P60028; A5A6L3;
DT 21-NOV-2003, integrated into UniProtKB/Swiss-Prot.
DT 21-NOV-2003, sequence version 1.
DT 03-AUG-2022, entry version 111.
DE RecName: Full=Rab GDP dissociation inhibitor alpha;
DE Short=Rab GDI alpha;
DE AltName: Full=Guanosine diphosphate dissociation inhibitor 1;
DE Short=GDI-1;
GN Name=GDI1; Synonyms=RABGDIA;
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=12777533; DOI=10.1093/molbev/msg134;
RA Kitano T., Schwarz C., Nickel B., Paeaebo S.;
RT "Gene diversity patterns at 10 X-chromosomal loci in humans and
RT chimpanzees.";
RL Mol. Biol. Evol. 20:1281-1289(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=15620360; DOI=10.1016/j.cell.2004.11.040;
RA Dorus S., Vallender E.J., Evans P.D., Anderson J.R., Gilbert S.L.,
RA Mahowald M., Wyckoff G.J., Malcom C.M., Lahn B.T.;
RT "Accelerated evolution of nervous system genes in the origin of Homo
RT sapiens.";
RL Cell 119:1027-1040(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Brain;
RX PubMed=17574350; DOI=10.1016/j.gene.2007.04.013;
RA Sakate R., Suto Y., Imanishi T., Tanoue T., Hida M., Hayasaka I.,
RA Kusuda J., Gojobori T., Hashimoto K., Hirai M.;
RT "Mapping of chimpanzee full-length cDNAs onto the human genome unveils
RT large potential divergence of the transcriptome.";
RL Gene 399:1-10(2007).
CC -!- FUNCTION: Regulates the GDP/GTP exchange reaction of most Rab proteins
CC by inhibiting the dissociation of GDP from them, and the subsequent
CC binding of GTP to them. Promotes the dissociation of GDP-bound Rab
CC proteins from the membrane and inhibits their activation. Promotes the
CC dissociation of RAB1A, RAB3A, RAB5A and RAB10 from membranes (By
CC similarity). {ECO:0000250}.
CC -!- SUBUNIT: Interacts with RHOH (By similarity). Interacts with the non-
CC phosphorylated forms of RAB1A, RAB3A, RAB5A, RAB5B, RAB5C, RAB8A,
CC RAB8B, RAB10, RAB12, RAB35, and RAB43 (By similarity).
CC {ECO:0000250|UniProtKB:P31150}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Golgi apparatus, trans-
CC Golgi network {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the Rab GDI family. {ECO:0000305}.
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DR EMBL; AB102648; BAC81117.1; -; mRNA.
DR EMBL; AY665281; AAV74319.1; -; mRNA.
DR EMBL; AB222141; BAF62386.1; -; mRNA.
DR RefSeq; NP_001009061.1; NM_001009061.1.
DR AlphaFoldDB; P60028; -.
DR SMR; P60028; -.
DR STRING; 9598.ENSPTRP00000047203; -.
DR PaxDb; P60028; -.
DR GeneID; 450155; -.
DR KEGG; ptr:450155; -.
DR CTD; 2664; -.
DR eggNOG; KOG1439; Eukaryota.
DR HOGENOM; CLU_021695_0_0_1; -.
DR InParanoid; P60028; -.
DR OrthoDB; 763627at2759; -.
DR TreeFam; TF300449; -.
DR Proteomes; UP000002277; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0005093; F:Rab GDP-dissociation inhibitor activity; ISS:UniProtKB.
DR GO; GO:0050771; P:negative regulation of axonogenesis; ISS:UniProtKB.
DR GO; GO:0090315; P:negative regulation of protein targeting to membrane; ISS:UniProtKB.
DR GO; GO:0015031; P:protein transport; IEA:InterPro.
DR GO; GO:0032482; P:Rab protein signal transduction; ISS:UniProtKB.
DR GO; GO:0016192; P:vesicle-mediated transport; IBA:GO_Central.
DR Gene3D; 3.50.50.60; -; 1.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR018203; GDP_dissociation_inhibitor.
DR InterPro; IPR000806; RabGDI.
DR PANTHER; PTHR11787; PTHR11787; 1.
DR Pfam; PF00996; GDI; 1.
DR PRINTS; PR00892; RABGDI.
DR PRINTS; PR00891; RABGDIREP.
DR SUPFAM; SSF51905; SSF51905; 2.
PE 2: Evidence at transcript level;
KW Cytoplasm; Golgi apparatus; GTPase activation; Reference proteome.
FT CHAIN 1..447
FT /note="Rab GDP dissociation inhibitor alpha"
FT /id="PRO_0000056674"
SQ SEQUENCE 447 AA; 50583 MW; BC283A445E50A652 CRC64;
MDEEYDVIVL GTGLTECILS GIMSVNGKKV LHMDRNPYYG GESSSITPLE ELYKRFQLLE
GPPESMGRGR DWNVDLIPKF LMANGQLVKM LLYTEVTRYL DFKVVEGSFV YKGGKIYKVP
STETEALASN LMGMFEKRRF RKFLVFVANF DENDPKTFEG VDPQTTSMRD VYRKFDLGQD
VIDFTGHALA LYRTDDYLDQ PCLETVNRIK LYSESLARYG KSPYLYPLYG LGELPQGFAR
LSAIYGGTYM LNKPVDDIIM ENGKVVGVKS EGEVARCKQL ICDPSYIPDR VRKAGQVIRI
ICILSHPIKN TNDANSCQII IPQNQVNRKS DIYVCMISYA HNVAAQGKYI AIASTTVETT
DPEKEVEPAL ELLEPIDQKF VAISDLYEPI DDGCESQVFC SCSYDATTHF ETTCNDIKDI
YKRMAGTAFD FENMKRKQND VFGEAEQ
