GDIR2_DICDI
ID GDIR2_DICDI Reviewed; 152 AA.
AC Q95UP9; Q54VG8;
DT 03-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 87.
DE RecName: Full=Putative rho GDP-dissociation inhibitor 2;
GN Name=rdiB; Synonyms=RhoGDI2; ORFNames=DDB_G0280049;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=12198156; DOI=10.1093/emboj/cdf449;
RA Rivero F., Illenberger D., Somesh B.P., Dislich H., Adam N., Meyer A.-K.;
RT "Defects in cytokinesis, actin reorganization and the contractile vacuole
RT in cells deficient in RhoGDI.";
RL EMBO J. 21:4539-4549(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- FUNCTION: Regulates the GDP/GTP exchange reaction of the Rho proteins
CC by inhibiting the dissociation of GDP from them, and the subsequent
CC binding of GTP to them. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the Rho GDI family. {ECO:0000305}.
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DR EMBL; AY044086; AAK95685.1; -; Genomic_DNA.
DR EMBL; AAFI02000035; EAL67251.1; -; Genomic_DNA.
DR RefSeq; XP_641387.1; XM_636295.1.
DR AlphaFoldDB; Q95UP9; -.
DR SMR; Q95UP9; -.
DR STRING; 44689.DDB0214829; -.
DR PaxDb; Q95UP9; -.
DR PRIDE; Q95UP9; -.
DR EnsemblProtists; EAL67251; EAL67251; DDB_G0280049.
DR GeneID; 8622521; -.
DR KEGG; ddi:DDB_G0280049; -.
DR dictyBase; DDB_G0280049; rdiB.
DR eggNOG; ENOG502RHIB; Eukaryota.
DR HOGENOM; CLU_1725720_0_0_1; -.
DR InParanoid; Q95UP9; -.
DR OMA; GDICANT; -.
DR PhylomeDB; Q95UP9; -.
DR Reactome; R-DDI-9013148; CDC42 GTPase cycle.
DR Reactome; R-DDI-9013149; RAC1 GTPase cycle.
DR Reactome; R-DDI-9013404; RAC2 GTPase cycle.
DR Reactome; R-DDI-9013407; RHOH GTPase cycle.
DR PRO; PR:Q95UP9; -.
DR Proteomes; UP000002195; Chromosome 3.
DR GO; GO:0005829; C:cytosol; IDA:dictyBase.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0005094; F:Rho GDP-dissociation inhibitor activity; IBA:GO_Central.
DR GO; GO:0035023; P:regulation of Rho protein signal transduction; TAS:dictyBase.
DR GO; GO:0007266; P:Rho protein signal transduction; IBA:GO_Central.
DR Gene3D; 2.70.50.30; -; 1.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR000406; Rho_GDI.
DR InterPro; IPR024792; RhoGDI_dom_sf.
DR PANTHER; PTHR10980; PTHR10980; 1.
DR SUPFAM; SSF81296; SSF81296; 1.
PE 3: Inferred from homology;
KW Cytoplasm; GTPase activation; Reference proteome.
FT CHAIN 1..152
FT /note="Putative rho GDP-dissociation inhibitor 2"
FT /id="PRO_0000365603"
SQ SEQUENCE 152 AA; 17208 MW; A12B5DE470E47976 CRC64;
MINHNIISFK KFEAIFEQRP GGLELNMPIE IGSNNVDLTS KPFNIKGGSH YKVKIGYMAS
EPITDLICQI HTFRKSTPYG RDTQKVGDIC ANTNDLEFDF PKFGWEQAST QSSSMGDYTI
KMYFKGNGNQ DLATFFYSFN VAPDWENALP IN