ID   GDIR3_BOVIN             Reviewed;         225 AA.
AC   Q0II80;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   03-OCT-2006, sequence version 1.
DT   03-AUG-2022, entry version 79.
DE   RecName: Full=Rho GDP-dissociation inhibitor 3;
DE            Short=Rho GDI 3;
DE   AltName: Full=Rho-GDI gamma;
GN   Name=ARHGDIG;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Hypothalamus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Inhibits GDP/GTP exchange reaction of RhoB. Interacts
CC       specifically with the GDP- and GTP-bound forms of post-translationally
CC       processed Rhob and Rhog proteins, both of which show a growth-regulated
CC       expression in mammalian cells. Stimulates the release of the GDP-bound
CC       but not the GTP-bound RhoB protein. Also inhibits the GDP/GTP exchange
CC       of RhoB but shows less ability to inhibit the dissociation of prebound
CC       GTP (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the Rho GDI family. {ECO:0000305}.
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DR   EMBL; BC122764; AAI22765.1; -; mRNA.
DR   RefSeq; NP_001069754.1; NM_001076286.1.
DR   AlphaFoldDB; Q0II80; -.
DR   SMR; Q0II80; -.
DR   STRING; 9913.ENSBTAP00000039941; -.
DR   PaxDb; Q0II80; -.
DR   Ensembl; ENSBTAT00000040162; ENSBTAP00000039941; ENSBTAG00000027854.
DR   GeneID; 613745; -.
DR   KEGG; bta:613745; -.
DR   CTD; 398; -.
DR   VEuPathDB; HostDB:ENSBTAG00000027854; -.
DR   VGNC; VGNC:26103; ARHGDIG.
DR   eggNOG; KOG3205; Eukaryota.
DR   GeneTree; ENSGT00940000161859; -.
DR   InParanoid; Q0II80; -.
DR   OrthoDB; 1265661at2759; -.
DR   Proteomes; UP000009136; Chromosome 25.
DR   Bgee; ENSBTAG00000027854; Expressed in temporal cortex and 75 other tissues.
DR   ExpressionAtlas; Q0II80; baseline and differential.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0016020; C:membrane; IBA:GO_Central.
DR   GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR   GO; GO:0005094; F:Rho GDP-dissociation inhibitor activity; IBA:GO_Central.
DR   GO; GO:0007266; P:Rho protein signal transduction; IBA:GO_Central.
DR   Gene3D; 2.70.50.30; -; 1.
DR   InterPro; IPR014756; Ig_E-set.
DR   InterPro; IPR000406; Rho_GDI.
DR   InterPro; IPR024792; RhoGDI_dom_sf.
DR   PANTHER; PTHR10980; PTHR10980; 1.
DR   Pfam; PF02115; Rho_GDI; 1.
DR   PRINTS; PR00492; RHOGDI.
DR   SUPFAM; SSF81296; SSF81296; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; GTPase activation; Reference proteome.
FT   CHAIN           1..225
FT                   /note="Rho GDP-dissociation inhibitor 3"
FT                   /id="PRO_0000318592"
SQ   SEQUENCE   225 AA;  25007 MW;  C7ABE1AEE6DC8882 CRC64;
     MLGLDACELG AQLLELLRLA LCARVLLTDK EGGQLPPEEA LDEAVPEYRA PGKKSLLEIQ
     QLDPDDESLV KYKRALLGPV LPAVDPSLPN VQVTRLTLIS EQAPGPIVMD LTGELAALKN
     QVFVLKEGVD YKVKITFKVN KEIVSGLKCL HHTYRHGLRV DKAVYMVGSY GPSAQEYEFV
     TPVEEAPRGA LVRGAYVVTS FFTDDDRTAH LSWEWGLYVC QDWER