GDIR3_MOUSE
ID GDIR3_MOUSE Reviewed; 225 AA.
AC Q62160;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1997, sequence version 1.
DT 03-AUG-2022, entry version 139.
DE RecName: Full=Rho GDP-dissociation inhibitor 3;
DE Short=Rho GDI 3;
DE AltName: Full=Rho-GDI gamma;
DE AltName: Full=Rho-GDI2;
GN Name=Arhgdig; Synonyms=Gdi5;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=BALB/cJ; TISSUE=Brain;
RX PubMed=8939998; DOI=10.1074/jbc.271.48.30366;
RA Zalcman G., Closson V., Camonis J., Honore N., Rousseau-Merck M.-F.,
RA Tavitian A., Olofsson B.;
RT "RhoGDI-3 is a new GDP dissociation inhibitor (GDI). Identification of a
RT non-cytosolic GDI protein interacting with the small GTP-binding proteins
RT RhoB and RhoG.";
RL J. Biol. Chem. 271:30366-30374(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Brain;
RA Gebbink M.F.B.G., Poland M., Kranenburg O., Vanhorck F.P.G.,
RA Moolenaar W.H.;
RL Submitted (DEC-1996) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Mammary gland;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Inhibits GDP/GTP exchange reaction of RhoB. Interacts
CC specifically with the GDP- and GTP-bound forms of post-translationally
CC processed Rhob and Rhog proteins, both of which show a growth-regulated
CC expression in mammalian cells. Stimulates the release of the GDP-bound
CC but not the GTP-bound RhoB protein. Also inhibits the GDP/GTP exchange
CC of RhoB but shows less ability to inhibit the dissociation of prebound
CC GTP.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Detected only in brain, lung, kidney and testis.
CC -!- SIMILARITY: Belongs to the Rho GDI family. {ECO:0000305}.
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DR EMBL; L42463; AAC37704.1; -; mRNA.
DR EMBL; U73198; AAB18196.1; -; mRNA.
DR EMBL; BC002032; AAH02032.1; -; mRNA.
DR CCDS; CCDS28548.1; -.
DR RefSeq; NP_032139.1; NM_008113.3.
DR AlphaFoldDB; Q62160; -.
DR SMR; Q62160; -.
DR STRING; 10090.ENSMUSP00000025019; -.
DR iPTMnet; Q62160; -.
DR PhosphoSitePlus; Q62160; -.
DR PaxDb; Q62160; -.
DR PRIDE; Q62160; -.
DR ProteomicsDB; 267791; -.
DR Antibodypedia; 34941; 173 antibodies from 35 providers.
DR DNASU; 14570; -.
DR Ensembl; ENSMUST00000025019; ENSMUSP00000025019; ENSMUSG00000073433.
DR GeneID; 14570; -.
DR KEGG; mmu:14570; -.
DR UCSC; uc008bdp.1; mouse.
DR CTD; 398; -.
DR MGI; MGI:108430; Arhgdig.
DR VEuPathDB; HostDB:ENSMUSG00000073433; -.
DR eggNOG; KOG3205; Eukaryota.
DR GeneTree; ENSGT00390000006233; -.
DR HOGENOM; CLU_076228_1_1_1; -.
DR InParanoid; Q62160; -.
DR OMA; EWGLCIK; -.
DR OrthoDB; 1265661at2759; -.
DR PhylomeDB; Q62160; -.
DR TreeFam; TF105387; -.
DR Reactome; R-MMU-9013026; RHOB GTPase cycle.
DR Reactome; R-MMU-9013148; CDC42 GTPase cycle.
DR Reactome; R-MMU-9013407; RHOH GTPase cycle.
DR Reactome; R-MMU-9013408; RHOG GTPase cycle.
DR BioGRID-ORCS; 14570; 2 hits in 74 CRISPR screens.
DR ChiTaRS; Arhgdig; mouse.
DR PRO; PR:Q62160; -.
DR Proteomes; UP000000589; Chromosome 17.
DR RNAct; Q62160; protein.
DR Bgee; ENSMUSG00000073433; Expressed in nasal cavity epithelium and 102 other tissues.
DR ExpressionAtlas; Q62160; baseline and differential.
DR Genevisible; Q62160; MM.
DR GO; GO:0005829; C:cytosol; ISO:MGI.
DR GO; GO:0016020; C:membrane; IDA:MGI.
DR GO; GO:0005886; C:plasma membrane; ISO:MGI.
DR GO; GO:0005092; F:GDP-dissociation inhibitor activity; IDA:MGI.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0030695; F:GTPase regulator activity; IDA:MGI.
DR GO; GO:0005094; F:Rho GDP-dissociation inhibitor activity; IBA:GO_Central.
DR GO; GO:0001835; P:blastocyst hatching; IMP:MGI.
DR GO; GO:0032880; P:regulation of protein localization; IDA:MGI.
DR GO; GO:0007266; P:Rho protein signal transduction; IBA:GO_Central.
DR Gene3D; 2.70.50.30; -; 1.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR000406; Rho_GDI.
DR InterPro; IPR024792; RhoGDI_dom_sf.
DR PANTHER; PTHR10980; PTHR10980; 1.
DR Pfam; PF02115; Rho_GDI; 1.
DR PRINTS; PR00492; RHOGDI.
DR SUPFAM; SSF81296; SSF81296; 1.
PE 2: Evidence at transcript level;
KW Cytoplasm; GTPase activation; Reference proteome.
FT CHAIN 1..225
FT /note="Rho GDP-dissociation inhibitor 3"
FT /id="PRO_0000219019"
SQ SEQUENCE 225 AA; 25296 MW; BBCA9B71AC9AAED8 CRC64;
MLGLDACELG EQLLELLRLA LCARVLLADK DGESTPSDEV LDEIVPEYQA PGKKSMLAIW
QLDPGDVSLV KYKQALLGPL PPIMDPSLPN VQVTRLTLLT EQAPGPIIMD LTGDLDALKN
QVFVLKEGIE YKVKITFKVN KEIVSGLKCL HHTYRRGLRV DKAIFMVGSY GPRAQEYEFV
TSVEEAPRGA LARGLYVVRS LFTDDDRLNH LSWEWHLHVC QDWKD
