GDIR_ARATH
ID GDIR_ARATH Reviewed; 240 AA.
AC Q9SFC6;
DT 11-JUL-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 25-MAY-2022, entry version 126.
DE RecName: Full=Rho GDP-dissociation inhibitor 1;
DE Short=AtRhoGDI1;
DE Short=Rho GDI-1;
GN Name=GDI1; OrderedLocusNames=At3g07880; ORFNames=F17A17.22;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE.
RA Bavlnka B., Cvrckova F., Zarsky V.;
RT "AtRHO GDI interacts with NtRop1 in yeast 2-hybrid system.";
RL Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130713; DOI=10.1038/35048706;
RA Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B.,
RA Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M.,
RA Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V.,
RA Choisne N., Artiguenave F., Robert C., Brottier P., Wincker P.,
RA Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H.,
RA Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H.,
RA Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A.,
RA Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H.,
RA Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J.,
RA Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B.,
RA Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D.,
RA de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E.,
RA Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G.,
RA Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X.,
RA Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M.,
RA Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B.,
RA Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J.,
RA Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C.,
RA Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y.,
RA Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K.,
RA Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A.,
RA Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T.,
RA Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana.";
RL Nature 408:820-822(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
RA Feldmann K.A.;
RT "Full-length cDNA from Arabidopsis thaliana.";
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP INTERACTION WITH ARAC5/ROP4 AND ARAC3/ROP6.
RX PubMed=10798620; DOI=10.1023/a:1006341210147;
RA Bischoff F., Vahlkamp L., Molendijk A.J., Palme K.;
RT "Localization of AtROP4 and AtROP6 and interaction with the guanine
RT nucleotide dissociation inhibitor AtRhoGDI1 from Arabidopsis.";
RL Plant Mol. Biol. 42:515-530(2000).
CC -!- FUNCTION: Regulates the GDP/GTP exchange reaction of the Rho proteins
CC by inhibiting the dissociation of GDP from them, and the subsequent
CC binding of GTP to them. {ECO:0000250}.
CC -!- SUBUNIT: Interacts with RAC-like GTP binding proteins ARAC5/ROP4 and
CC ARAC3/ROP6. {ECO:0000269|PubMed:10798620}.
CC -!- INTERACTION:
CC Q9SFC6; Q38937: ARAC5; NbExp=2; IntAct=EBI-1751328, EBI-1751308;
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the Rho GDI family. {ECO:0000305}.
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DR EMBL; AF412276; AAL10299.1; -; mRNA.
DR EMBL; AC013483; AAF21198.1; -; Genomic_DNA.
DR EMBL; CP002686; AEE74614.1; -; Genomic_DNA.
DR EMBL; BT005578; AAO63998.1; -; mRNA.
DR EMBL; AY085508; AAM62732.1; -; mRNA.
DR RefSeq; NP_187445.1; NM_111667.4.
DR AlphaFoldDB; Q9SFC6; -.
DR SMR; Q9SFC6; -.
DR BioGRID; 5314; 5.
DR IntAct; Q9SFC6; 2.
DR STRING; 3702.AT3G07880.1; -.
DR iPTMnet; Q9SFC6; -.
DR PaxDb; Q9SFC6; -.
DR PRIDE; Q9SFC6; -.
DR ProteomicsDB; 247082; -.
DR EnsemblPlants; AT3G07880.1; AT3G07880.1; AT3G07880.
DR GeneID; 819979; -.
DR Gramene; AT3G07880.1; AT3G07880.1; AT3G07880.
DR KEGG; ath:AT3G07880; -.
DR Araport; AT3G07880; -.
DR TAIR; locus:2077462; AT3G07880.
DR eggNOG; KOG3205; Eukaryota.
DR HOGENOM; CLU_076228_0_0_1; -.
DR InParanoid; Q9SFC6; -.
DR OMA; HLKFEWS; -.
DR OrthoDB; 1265661at2759; -.
DR PhylomeDB; Q9SFC6; -.
DR PRO; PR:Q9SFC6; -.
DR Proteomes; UP000006548; Chromosome 3.
DR ExpressionAtlas; Q9SFC6; baseline and differential.
DR Genevisible; Q9SFC6; AT.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0005094; F:Rho GDP-dissociation inhibitor activity; IBA:GO_Central.
DR GO; GO:0009932; P:cell tip growth; IMP:TAIR.
DR GO; GO:0007266; P:Rho protein signal transduction; IBA:GO_Central.
DR GO; GO:0010053; P:root epidermal cell differentiation; IMP:TAIR.
DR Gene3D; 2.70.50.30; -; 1.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR000406; Rho_GDI.
DR InterPro; IPR024792; RhoGDI_dom_sf.
DR PANTHER; PTHR10980; PTHR10980; 1.
DR Pfam; PF02115; Rho_GDI; 1.
DR PRINTS; PR00492; RHOGDI.
DR SUPFAM; SSF81296; SSF81296; 1.
PE 1: Evidence at protein level;
KW Cytoplasm; GTPase activation; Reference proteome.
FT CHAIN 1..240
FT /note="Rho GDP-dissociation inhibitor 1"
FT /id="PRO_0000219021"
FT REGION 1..66
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 15..41
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 240 AA; 27231 MW; DD1A504F8EC1459F CRC64;
MSLVSGARDM GFDDNNNNKN NKDGDDENSS SRTRADDDAL SRQMSESSLC ATEEEEDDDS
KLQLGPQYTI KEHLEKDKDD ESLRKWKEQL LGSVDVTNIG ETLDPEVRID SLAIISPGRP
DIVLLVPENG NPKGMWFTLK EGSKYNLKFT FHVNNNIVSG LRYTNTVWKT GVKVDRAKEM
LGTFSPQLEP YNHVMPEETT PSGMFARGSY SARTKFLDDD NKCYLEINYS FDIRKEWPAL
