ID   GDIR_CAEEL              Reviewed;         191 AA.
AC   Q20496;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 1.
DT   03-AUG-2022, entry version 130.
DE   RecName: Full=Probable rho GDP-dissociation inhibitor;
DE            Short=Rho GDI;
GN   Name=rhi-1; ORFNames=F46H6.1;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- FUNCTION: Regulates the GDP/GTP exchange reaction of the Rho proteins
CC       by inhibiting the dissociation of GDP from them, and the subsequent
CC       binding of GTP to them. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the Rho GDI family. {ECO:0000305}.
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DR   EMBL; FO080405; CCD63475.1; -; Genomic_DNA.
DR   PIR; T16379; T16379.
DR   RefSeq; NP_508774.1; NM_076373.5.
DR   AlphaFoldDB; Q20496; -.
DR   SMR; Q20496; -.
DR   BioGRID; 45656; 3.
DR   STRING; 6239.F46H6.1; -.
DR   iPTMnet; Q20496; -.
DR   EPD; Q20496; -.
DR   PaxDb; Q20496; -.
DR   PeptideAtlas; Q20496; -.
DR   PRIDE; Q20496; -.
DR   EnsemblMetazoa; F46H6.1.1; F46H6.1.1; WBGene00004356.
DR   GeneID; 180721; -.
DR   KEGG; cel:CELE_F46H6.1; -.
DR   UCSC; F46H6.1.1; c. elegans.
DR   CTD; 180721; -.
DR   WormBase; F46H6.1; CE04595; WBGene00004356; rhi-1.
DR   eggNOG; KOG3205; Eukaryota.
DR   GeneTree; ENSGT00390000006233; -.
DR   HOGENOM; CLU_076228_1_1_1; -.
DR   InParanoid; Q20496; -.
DR   OMA; KHHPEHH; -.
DR   OrthoDB; 1265661at2759; -.
DR   PhylomeDB; Q20496; -.
DR   Reactome; R-CEL-8980692; RHOA GTPase cycle.
DR   Reactome; R-CEL-9013026; RHOB GTPase cycle.
DR   Reactome; R-CEL-9013106; RHOC GTPase cycle.
DR   Reactome; R-CEL-9013148; CDC42 GTPase cycle.
DR   Reactome; R-CEL-9013149; RAC1 GTPase cycle.
DR   Reactome; R-CEL-9013407; RHOH GTPase cycle.
DR   PRO; PR:Q20496; -.
DR   Proteomes; UP000001940; Chromosome X.
DR   Bgee; WBGene00004356; Expressed in pharyngeal muscle cell (C elegans) and 4 other tissues.
DR   GO; GO:0005829; C:cytosol; IDA:WormBase.
DR   GO; GO:0016020; C:membrane; IDA:WormBase.
DR   GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR   GO; GO:0005094; F:Rho GDP-dissociation inhibitor activity; IBA:GO_Central.
DR   GO; GO:0007266; P:Rho protein signal transduction; IBA:GO_Central.
DR   Gene3D; 2.70.50.30; -; 1.
DR   InterPro; IPR014756; Ig_E-set.
DR   InterPro; IPR000406; Rho_GDI.
DR   InterPro; IPR024792; RhoGDI_dom_sf.
DR   PANTHER; PTHR10980; PTHR10980; 1.
DR   Pfam; PF02115; Rho_GDI; 1.
DR   PRINTS; PR00492; RHOGDI.
DR   SUPFAM; SSF81296; SSF81296; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; GTPase activation; Reference proteome.
FT   CHAIN           1..191
FT                   /note="Probable rho GDP-dissociation inhibitor"
FT                   /id="PRO_0000219020"
FT   REGION          1..22
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   191 AA;  21919 MW;  66A5B84ED0BCD450 CRC64;
     MSDHENTGEN TSEYQYKQPP QKSIDELLNA DKEDESLKVY KAKLLGQGTV IVDEKNPLRV
     IVRSVELLIN GKTAQSFDLS DPAKLVNSDL SVSIKEGSNY RLSFAFHVQR EITSGLHYKH
     KVKRSGITVE NEKYMMGSYA PKLEIQEYKS PNEEAPSGMM HRGKYKVYSK ITDDDNNVYL
     DWQWTLHITK E