GDL10_ARATH
ID GDL10_ARATH Reviewed; 383 AA.
AC Q9SHP6; Q94JT8;
DT 24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 2.
DT 03-AUG-2022, entry version 119.
DE RecName: Full=GDSL esterase/lipase At1g28610;
DE EC=3.1.1.-;
DE AltName: Full=Extracellular lipase At1g28610;
DE Flags: Precursor;
GN OrderedLocusNames=At1g28610; ORFNames=F1K23.16;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=cv. Columbia;
RX PubMed=14993207; DOI=10.1101/gr.1515604;
RA Castelli V., Aury J.-M., Jaillon O., Wincker P., Clepet C., Menard M.,
RA Cruaud C., Quetier F., Scarpelli C., Schaechter V., Temple G., Caboche M.,
RA Weissenbach J., Salanoubat M.;
RT "Whole genome sequence comparisons and 'full-length' cDNA sequences: a
RT combined approach to evaluate and improve Arabidopsis genome annotation.";
RL Genome Res. 14:406-413(2004).
RN [5]
RP REVIEW.
RX PubMed=15522763; DOI=10.1016/j.plipres.2004.09.002;
RA Akoh C.C., Lee G.-C., Liaw Y.-C., Huang T.-H., Shaw J.-F.;
RT "GDSL family of serine esterases/lipases.";
RL Prog. Lipid Res. 43:534-552(2004).
RN [6]
RP GENE FAMILY.
RX PubMed=18819574; DOI=10.3923/pjbs.2008.763.767;
RA Ling H.;
RT "Sequence analysis of GDSL lipase gene family in Arabidopsis thaliana.";
RL Pak. J. Biol. Sci. 11:763-767(2008).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9SHP6-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9SHP6-2; Sequence=VSP_036689;
CC -!- SIMILARITY: Belongs to the 'GDSL' lipolytic enzyme family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BX814880; Type=Miscellaneous discrepancy; Note=Sequencing errors.; Evidence={ECO:0000305};
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DR EMBL; AC007508; AAG22835.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE31001.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE31002.1; -; Genomic_DNA.
DR EMBL; AF372948; AAK50088.1; -; mRNA.
DR EMBL; AY133590; AAM91420.1; -; mRNA.
DR EMBL; BX814880; -; NOT_ANNOTATED_CDS; mRNA.
DR PIR; F86411; F86411.
DR RefSeq; NP_564313.1; NM_102629.2. [Q9SHP6-2]
DR RefSeq; NP_973932.1; NM_202203.2. [Q9SHP6-1]
DR AlphaFoldDB; Q9SHP6; -.
DR SMR; Q9SHP6; -.
DR BioGRID; 24996; 1.
DR IntAct; Q9SHP6; 1.
DR PaxDb; Q9SHP6; -.
DR PRIDE; Q9SHP6; -.
DR ProteomicsDB; 224747; -. [Q9SHP6-1]
DR EnsemblPlants; AT1G28610.1; AT1G28610.1; AT1G28610. [Q9SHP6-2]
DR EnsemblPlants; AT1G28610.2; AT1G28610.2; AT1G28610. [Q9SHP6-1]
DR GeneID; 839761; -.
DR Gramene; AT1G28610.1; AT1G28610.1; AT1G28610. [Q9SHP6-2]
DR Gramene; AT1G28610.2; AT1G28610.2; AT1G28610. [Q9SHP6-1]
DR KEGG; ath:AT1G28610; -.
DR Araport; AT1G28610; -.
DR TAIR; locus:2018733; AT1G28610.
DR eggNOG; ENOG502QSMM; Eukaryota.
DR HOGENOM; CLU_015101_2_1_1; -.
DR InParanoid; Q9SHP6; -.
DR OMA; IVFVACY; -.
DR PhylomeDB; Q9SHP6; -.
DR BioCyc; ARA:AT1G28610-MON; -.
DR PRO; PR:Q9SHP6; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q9SHP6; baseline and differential.
DR Genevisible; Q9SHP6; AT.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0016788; F:hydrolase activity, acting on ester bonds; IEA:InterPro.
DR GO; GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW.
DR CDD; cd01837; SGNH_plant_lipase_like; 1.
DR Gene3D; 3.40.50.1110; -; 1.
DR InterPro; IPR001087; GDSL.
DR InterPro; IPR036514; SGNH_hydro_sf.
DR InterPro; IPR035669; SGNH_plant_lipase-like.
DR Pfam; PF00657; Lipase_GDSL; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Glycoprotein; Hydrolase; Lipid degradation;
KW Lipid metabolism; Reference proteome; Secreted; Signal.
FT SIGNAL 1..22
FT /evidence="ECO:0000255"
FT CHAIN 23..383
FT /note="GDSL esterase/lipase At1g28610"
FT /id="PRO_0000367352"
FT ACT_SITE 38
FT /note="Nucleophile"
FT /evidence="ECO:0000250"
FT ACT_SITE 340
FT /evidence="ECO:0000250"
FT ACT_SITE 343
FT /evidence="ECO:0000250"
FT CARBOHYD 134
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 184
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 315
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VAR_SEQ 206..383
FT /note="ELVDMGGRTFLVPGNFPLGCSATYLTLYQTSNKEEYDPLTGCLTWLNDFSEY
FT YNEKLQAELNRLSKLYPHVNIIYGDYFNALLRLYQEPSKFGFMDRPLPACCGLGGPYNF
FT TLSKKCGSVGVKYCSDPSKYVNWDGVHMTEAAYKWIADGLLKGPYTIPSFHWLCLGSKI
FT KSKESLDT -> VNILDQRVPRTSNFFKKLLCFLFCFCVLVLNVESRSWSIWEEEHS
FT (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14593172"
FT /id="VSP_036689"
SQ SEQUENCE 383 AA; 42427 MW; 2E39221E149BC63B CRC64;
MASLDSLVSF FLSTLFVTIV SSQTQCRNLE SIISFGDSIT DTGNLVGLSD RNHLPVTAFL
PYGETFFHHP TGRSCNGRII IDFIAEFLGL PHVPPFYGSK NGNFEKGVNF AVAGATALET
SILEKRGIYY PHSNISLGIQ LKTFKESLPN LCGSPTDCRD MIGNAFIIMG EIGGNDFNFA
FFVNKTSEVK ELVPLVITKI SSAIVELVDM GGRTFLVPGN FPLGCSATYL TLYQTSNKEE
YDPLTGCLTW LNDFSEYYNE KLQAELNRLS KLYPHVNIIY GDYFNALLRL YQEPSKFGFM
DRPLPACCGL GGPYNFTLSK KCGSVGVKYC SDPSKYVNWD GVHMTEAAYK WIADGLLKGP
YTIPSFHWLC LGSKIKSKES LDT
