GDL24_ARATH
ID GDL24_ARATH Reviewed; 349 AA.
AC Q9C653; F4IBD5;
DT 24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT 22-JUL-2015, sequence version 2.
DT 03-AUG-2022, entry version 108.
DE RecName: Full=GDSL esterase/lipase At1g58525;
DE EC=3.1.1.-;
DE AltName: Full=Extracellular lipase At1g58525;
DE Flags: Precursor;
GN OrderedLocusNames=At1g58525; ORFNames=F9K23.12;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP REVIEW.
RX PubMed=15522763; DOI=10.1016/j.plipres.2004.09.002;
RA Akoh C.C., Lee G.-C., Liaw Y.-C., Huang T.-H., Shaw J.-F.;
RT "GDSL family of serine esterases/lipases.";
RL Prog. Lipid Res. 43:534-552(2004).
RN [4]
RP GENE FAMILY.
RX PubMed=18819574; DOI=10.3923/pjbs.2008.763.767;
RA Ling H.;
RT "Sequence analysis of GDSL lipase gene family in Arabidopsis thaliana.";
RL Pak. J. Biol. Sci. 11:763-767(2008).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=1;
CC Comment=A number of isoforms are produced. According to EST
CC sequences.;
CC Name=1;
CC IsoId=Q9C653-1; Sequence=Displayed;
CC -!- SIMILARITY: Belongs to the 'GDSL' lipolytic enzyme family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAG50643.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=AEE33555.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AC082643; AAG50643.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002684; AEE33555.1; ALT_SEQ; Genomic_DNA.
DR PIR; G96618; G96618.
DR RefSeq; NP_001154437.1; NM_001160965.1.
DR RefSeq; NP_001333135.1; NM_001346206.1.
DR AlphaFoldDB; Q9C653; -.
DR SMR; Q9C653; -.
DR BioGRID; 27443; 8.
DR PeptideAtlas; Q9C653; -.
DR PRIDE; Q9C653; -.
DR GeneID; 28717378; -.
DR KEGG; ath:AT1G58525; -.
DR Araport; AT1G58525; -.
DR HOGENOM; CLU_015101_0_1_1; -.
DR InParanoid; Q9C653; -.
DR PRO; PR:Q9C653; -.
DR Proteomes; UP000006548; Chromosome 1.
DR Genevisible; Q9C653; AT.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0016298; F:lipase activity; IEA:InterPro.
DR GO; GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW.
DR CDD; cd01837; SGNH_plant_lipase_like; 1.
DR Gene3D; 3.40.50.1110; -; 1.
DR InterPro; IPR001087; GDSL.
DR InterPro; IPR008265; Lipase_GDSL_AS.
DR InterPro; IPR036514; SGNH_hydro_sf.
DR InterPro; IPR035669; SGNH_plant_lipase-like.
DR Pfam; PF00657; Lipase_GDSL; 1.
DR PROSITE; PS01098; LIPASE_GDSL_SER; 1.
PE 3: Inferred from homology;
KW Alternative splicing; Glycoprotein; Hydrolase; Lipid degradation;
KW Lipid metabolism; Reference proteome; Secreted; Signal.
FT SIGNAL 1..19
FT /evidence="ECO:0000255"
FT CHAIN 20..349
FT /note="GDSL esterase/lipase At1g58525"
FT /id="PRO_0000367366"
FT ACT_SITE 37
FT /note="Nucleophile"
FT /evidence="ECO:0000250"
FT ACT_SITE 324
FT /evidence="ECO:0000250"
FT ACT_SITE 327
FT /evidence="ECO:0000250"
FT CARBOHYD 25
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 316
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 349 AA; 38839 MW; 5C780E2FFA0B0514 CRC64;
MKLQILLLAL VLIAVEANAV KQGINATIPA LIVFGDSIMD TGNNNNLPTL LKCNFPPYGK
DYPGGDATGR FSDGRVPSDL IAEKLGLAKT LPAYMNSYLK PEDLLKGVTF ASRGTGYDPL
TAKIMSVISV WDQLIYFKEY ISKIKRHFGE EKAKDILEHS FFLVVSSSND LAHTYLAQAH
RYDRTSYANF LADSAVHFVR ELHKLGARKI GVFSAVPVGC VPLQRTVFGG FFTRGCNEPL
NNMAKQFNAR LSPALDSLDK ELDGVILYIN VYDTLFDMIQ HPKKYGFDVA DKGCCGKGLL
TISYLCNSLN PFTCSNSSSY IFWDSYHPSE RAYQVIVDNL LDKYLSKVY
