GDL46_ARATH
ID GDL46_ARATH Reviewed; 312 AA.
AC O80443; Q8W4R1;
DT 24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1998, sequence version 1.
DT 25-MAY-2022, entry version 107.
DE RecName: Full=GDSL esterase/lipase At2g38180;
DE EC=3.1.1.-;
DE AltName: Full=Extracellular lipase At2g38180;
DE Flags: Precursor;
GN OrderedLocusNames=At2g38180; ORFNames=F16M14.11;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617197; DOI=10.1038/45471;
RA Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL Nature 402:761-768(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Shinn P., Chen H., Cheuk R.F., Kim C.J., Ecker J.R.;
RT "Arabidopsis ORF clone.";
RL Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP REVIEW.
RX PubMed=15522763; DOI=10.1016/j.plipres.2004.09.002;
RA Akoh C.C., Lee G.-C., Liaw Y.-C., Huang T.-H., Shaw J.-F.;
RT "GDSL family of serine esterases/lipases.";
RL Prog. Lipid Res. 43:534-552(2004).
RN [6]
RP GENE FAMILY.
RX PubMed=18819574; DOI=10.3923/pjbs.2008.763.767;
RA Ling H.;
RT "Sequence analysis of GDSL lipase gene family in Arabidopsis thaliana.";
RL Pak. J. Biol. Sci. 11:763-767(2008).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the 'GDSL' lipolytic enzyme family.
CC {ECO:0000305}.
CC -!- CAUTION: Lacks the conserved active site 'GDSL' motif. Its enzyme
CC activity is therefore unsure. {ECO:0000305}.
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DR EMBL; AC003028; AAC27167.1; -; Genomic_DNA.
DR EMBL; CP002685; AEC09502.1; -; Genomic_DNA.
DR EMBL; AY060593; AAL31218.1; -; mRNA.
DR EMBL; BT021087; AAX12857.1; -; mRNA.
DR EMBL; BT021116; AAX12886.1; -; mRNA.
DR PIR; T01250; T01250.
DR RefSeq; NP_565883.1; NM_129374.4.
DR AlphaFoldDB; O80443; -.
DR SMR; O80443; -.
DR STRING; 3702.AT2G38180.1; -.
DR PaxDb; O80443; -.
DR PRIDE; O80443; -.
DR ProteomicsDB; 247095; -.
DR EnsemblPlants; AT2G38180.1; AT2G38180.1; AT2G38180.
DR GeneID; 818396; -.
DR Gramene; AT2G38180.1; AT2G38180.1; AT2G38180.
DR KEGG; ath:AT2G38180; -.
DR Araport; AT2G38180; -.
DR TAIR; locus:2042862; AT2G38180.
DR eggNOG; KOG3035; Eukaryota.
DR HOGENOM; CLU_051989_0_2_1; -.
DR InParanoid; O80443; -.
DR OMA; NEQLEPP; -.
DR OrthoDB; 1226154at2759; -.
DR PhylomeDB; O80443; -.
DR PRO; PR:O80443; -.
DR Proteomes; UP000006548; Chromosome 2.
DR ExpressionAtlas; O80443; baseline and differential.
DR Genevisible; O80443; AT.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.1110; -; 1.
DR InterPro; IPR045136; Iah1-like.
DR InterPro; IPR013830; SGNH_hydro.
DR InterPro; IPR036514; SGNH_hydro_sf.
DR PANTHER; PTHR14209; PTHR14209; 1.
DR Pfam; PF13472; Lipase_GDSL_2; 1.
PE 2: Evidence at transcript level;
KW Glycoprotein; Hydrolase; Lipid degradation; Lipid metabolism;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1..22
FT /evidence="ECO:0000255"
FT CHAIN 23..312
FT /note="GDSL esterase/lipase At2g38180"
FT /id="PRO_0000367387"
FT REGION 285..312
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 79
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CONFLICT 255
FT /note="C -> F (in Ref. 3; AAL31218)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 312 AA; 35405 MW; 4FB948CB0ED617BA CRC64;
MVGPVRPQIV LFGSSIVQYS FTDRGWGATL ADLYSRTADI ILRGYAGWNS RFALKVLHQV
FPKDAVIQPS LVIVYFGGND STHPHPSGHG PHVPLSEFIE NMRKIGEHLL SLSDKTRVIF
LTPPPMNEKQ IEIVFGDAIK GRSNELCRPY AEELLNLCRE INVKGIDIWT AIQQQDDWLN
SCFTDGIHFT AKASEIVVKE ILKVLRGADW KPSLYWKSLP VEFPFDFDAP NSISLHDLEL
TRNNHFESPH LVSLCEQELT RNEQLEPPHP VSLCDHELTR NEQLEPPHPV SLCDHELTQN
EQLEPPQPTA RL
