ID   GDL52_ARATH             Reviewed;         351 AA.
AC   Q9LH73;
DT   24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   24-MAR-2009, sequence version 2.
DT   03-AUG-2022, entry version 103.
DE   RecName: Full=GDSL esterase/lipase At3g14820;
DE            EC=3.1.1.-;
DE   AltName: Full=Extracellular lipase At3g14820;
DE   Flags: Precursor;
GN   OrderedLocusNames=At3g14820; ORFNames=T21E2.10;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=10907853; DOI=10.1093/dnares/7.3.217;
RA   Kaneko T., Katoh T., Sato S., Nakamura Y., Asamizu E., Tabata S.;
RT   "Structural analysis of Arabidopsis thaliana chromosome 3. II. Sequence
RT   features of the 4,251,695 bp regions covered by 90 P1, TAC and BAC
RT   clones.";
RL   DNA Res. 7:217-221(2000).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [3]
RP   REVIEW.
RX   PubMed=15522763; DOI=10.1016/j.plipres.2004.09.002;
RA   Akoh C.C., Lee G.-C., Liaw Y.-C., Huang T.-H., Shaw J.-F.;
RT   "GDSL family of serine esterases/lipases.";
RL   Prog. Lipid Res. 43:534-552(2004).
RN   [4]
RP   GENE FAMILY.
RX   PubMed=18819574; DOI=10.3923/pjbs.2008.763.767;
RA   Ling H.;
RT   "Sequence analysis of GDSL lipase gene family in Arabidopsis thaliana.";
RL   Pak. J. Biol. Sci. 11:763-767(2008).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the 'GDSL' lipolytic enzyme family.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAB02648.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; AP002061; BAB02648.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; CP002686; AEE75570.1; -; Genomic_DNA.
DR   RefSeq; NP_188100.2; NM_112343.2.
DR   AlphaFoldDB; Q9LH73; -.
DR   SMR; Q9LH73; -.
DR   PaxDb; Q9LH73; -.
DR   PRIDE; Q9LH73; -.
DR   ProteomicsDB; 224761; -.
DR   EnsemblPlants; AT3G14820.1; AT3G14820.1; AT3G14820.
DR   GeneID; 820711; -.
DR   Gramene; AT3G14820.1; AT3G14820.1; AT3G14820.
DR   KEGG; ath:AT3G14820; -.
DR   Araport; AT3G14820; -.
DR   TAIR; locus:2099387; AT3G14820.
DR   eggNOG; ENOG502SJTB; Eukaryota.
DR   HOGENOM; CLU_015101_0_1_1; -.
DR   InParanoid; Q9LH73; -.
DR   OMA; WARSLEY; -.
DR   OrthoDB; 704138at2759; -.
DR   PhylomeDB; Q9LH73; -.
DR   BioCyc; ARA:AT3G14820-MON; -.
DR   PRO; PR:Q9LH73; -.
DR   Proteomes; UP000006548; Chromosome 3.
DR   ExpressionAtlas; Q9LH73; baseline and differential.
DR   Genevisible; Q9LH73; AT.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0016298; F:lipase activity; IEA:InterPro.
DR   GO; GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW.
DR   CDD; cd01837; SGNH_plant_lipase_like; 1.
DR   Gene3D; 3.40.50.1110; -; 1.
DR   InterPro; IPR001087; GDSL.
DR   InterPro; IPR008265; Lipase_GDSL_AS.
DR   InterPro; IPR036514; SGNH_hydro_sf.
DR   InterPro; IPR035669; SGNH_plant_lipase-like.
DR   Pfam; PF00657; Lipase_GDSL; 1.
DR   PROSITE; PS01098; LIPASE_GDSL_SER; 1.
PE   3: Inferred from homology;
KW   Glycoprotein; Hydrolase; Lipid degradation; Lipid metabolism;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   CHAIN           23..351
FT                   /note="GDSL esterase/lipase At3g14820"
FT                   /id="PRO_0000367393"
FT   ACT_SITE        39
FT                   /note="Nucleophile"
FT                   /evidence="ECO:0000250"
FT   ACT_SITE        325
FT                   /evidence="ECO:0000250"
FT   ACT_SITE        328
FT                   /evidence="ECO:0000250"
FT   CARBOHYD        25
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   351 AA;  39194 MW;  99F2D5992A5EA57B CRC64;
     MDLHLIGFLL WFFVVQVTTS SAHRNITTTI PALIVFGDSI MDTGNNNDIP TLLKSNFPPY
     GRDFPGAIPT GRFSDGKVPS DIIAESLGIA KTLPPYLGSN LKPHDLLKGV IFASGGSGYD
     PLTSTLLSVV SMSDQLKYFQ EYLAKIKQHF GEEKVKFILE KSVFLVVSSS NDLAETYWVR
     SVEYDRNSYA EYLVELASEF IKELSELGAK NIGLFSGVPV GCLPAQRTLF GGFERKCYEK
     LNNMALHFNS KLSSSLDTLK KELPSRLIFI DVYDTLLDII KNPTNYGFKV ADKGCCGTGK
     IELMELCNKF TPFTCSDAST HVFFDSYHPS EKAYQIITHK LLAKYRKYLN T