GDL72_ARATH
ID GDL72_ARATH Reviewed; 353 AA.
AC Q9FFN0; B0ZCL3; B0ZCL4; B0ZCL9; B0ZCM0; B0ZCM2; Q9LZC6;
DT 24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 100.
DE RecName: Full=GDSL esterase/lipase At5g03810;
DE EC=3.1.1.-;
DE AltName: Full=Extracellular lipase At5g03810;
DE Flags: Precursor;
GN OrderedLocusNames=At5g03810; ORFNames=F8F6.20, MED24.11;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=9330910; DOI=10.1093/dnares/4.3.215;
RA Sato S., Kotani H., Nakamura Y., Kaneko T., Asamizu E., Fukami M.,
RA Miyajima N., Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 5. I. Sequence
RT features of the 1.6 Mb regions covered by twenty physically assigned P1
RT clones.";
RL DNA Res. 4:215-230(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130714; DOI=10.1038/35048507;
RA Tabata S., Kaneko T., Nakamura Y., Kotani H., Kato T., Asamizu E.,
RA Miyajima N., Sasamoto S., Kimura T., Hosouchi T., Kawashima K., Kohara M.,
RA Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Naruo K.,
RA Okumura S., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M.,
RA Yasuda M., Sato S., de la Bastide M., Huang E., Spiegel L., Gnoj L.,
RA O'Shaughnessy A., Preston R., Habermann K., Murray J., Johnson D.,
RA Rohlfing T., Nelson J., Stoneking T., Pepin K., Spieth J., Sekhon M.,
RA Armstrong J., Becker M., Belter E., Cordum H., Cordes M., Courtney L.,
RA Courtney W., Dante M., Du H., Edwards J., Fryman J., Haakensen B.,
RA Lamar E., Latreille P., Leonard S., Meyer R., Mulvaney E., Ozersky P.,
RA Riley A., Strowmatt C., Wagner-McPherson C., Wollam A., Yoakum M., Bell M.,
RA Dedhia N., Parnell L., Shah R., Rodriguez M., Hoon See L., Vil D.,
RA Baker J., Kirchoff K., Toth K., King L., Bahret A., Miller B., Marra M.A.,
RA Martienssen R., McCombie W.R., Wilson R.K., Murphy G., Bancroft I.,
RA Volckaert G., Wambutt R., Duesterhoeft A., Stiekema W., Pohl T.,
RA Entian K.-D., Terryn N., Hartley N., Bent E., Johnson S., Langham S.-A.,
RA McCullagh B., Robben J., Grymonprez B., Zimmermann W., Ramsperger U.,
RA Wedler H., Balke K., Wedler E., Peters S., van Staveren M., Dirkse W.,
RA Mooijman P., Klein Lankhorst R., Weitzenegger T., Bothe G., Rose M.,
RA Hauf J., Berneiser S., Hempel S., Feldpausch M., Lamberth S.,
RA Villarroel R., Gielen J., Ardiles W., Bents O., Lemcke K., Kolesov G.,
RA Mayer K.F.X., Rudd S., Schoof H., Schueller C., Zaccaria P., Mewes H.-W.,
RA Bevan M., Fransz P.F.;
RT "Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana.";
RL Nature 408:823-826(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-289, AND VARIANTS ASP-98; THR-150
RP AND ARG-193.
RC STRAIN=cv. Bla-10, cv. Chi-1, cv. Co-1, cv. Columbia, cv. Cvi-0,
RC cv. Da(1)-12, cv. Di-G, cv. Gr-3, cv. Landsberg erecta, cv. Li-3, cv. Mt-0,
RC cv. PHW-1, cv. PHW-32, and cv. Sha;
RX PubMed=18273534; DOI=10.1007/s00239-007-9063-3;
RA Moore R.C., Stevens M.H.H.;
RT "Local patterns of nucleotide polymorphism are highly variable in the
RT selfing species Arabidopsis thaliana.";
RL J. Mol. Evol. 66:116-129(2008).
RN [5]
RP REVIEW.
RX PubMed=15522763; DOI=10.1016/j.plipres.2004.09.002;
RA Akoh C.C., Lee G.-C., Liaw Y.-C., Huang T.-H., Shaw J.-F.;
RT "GDSL family of serine esterases/lipases.";
RL Prog. Lipid Res. 43:534-552(2004).
RN [6]
RP GENE FAMILY.
RX PubMed=18819574; DOI=10.3923/pjbs.2008.763.767;
RA Ling H.;
RT "Sequence analysis of GDSL lipase gene family in Arabidopsis thaliana.";
RL Pak. J. Biol. Sci. 11:763-767(2008).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the 'GDSL' lipolytic enzyme family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAB85501.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AB005235; BAB08607.1; -; Genomic_DNA.
DR EMBL; AL162873; CAB85501.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002688; AED90657.1; -; Genomic_DNA.
DR EMBL; EU352030; ABZ85648.1; -; Genomic_DNA.
DR EMBL; EU352031; ABZ85649.1; -; Genomic_DNA.
DR EMBL; EU352032; ABZ85650.1; -; Genomic_DNA.
DR EMBL; EU352033; ABZ85651.1; -; Genomic_DNA.
DR EMBL; EU352034; ABZ85652.1; -; Genomic_DNA.
DR EMBL; EU352035; ABZ85653.1; -; Genomic_DNA.
DR EMBL; EU352036; ABZ85654.1; -; Genomic_DNA.
DR EMBL; EU352037; ABZ85655.1; -; Genomic_DNA.
DR EMBL; EU352038; ABZ85656.1; -; Genomic_DNA.
DR EMBL; EU352039; ABZ85657.1; -; Genomic_DNA.
DR EMBL; EU352040; ABZ85658.1; -; Genomic_DNA.
DR EMBL; EU352041; ABZ85659.1; -; Genomic_DNA.
DR EMBL; EU352042; ABZ85660.1; -; Genomic_DNA.
DR EMBL; EU352043; ABZ85661.1; -; Genomic_DNA.
DR PIR; T48408; T48408.
DR RefSeq; NP_196001.2; NM_120462.2.
DR AlphaFoldDB; Q9FFN0; -.
DR SMR; Q9FFN0; -.
DR STRING; 3702.AT5G03810.1; -.
DR PaxDb; Q9FFN0; -.
DR ProteomicsDB; 221988; -.
DR EnsemblPlants; AT5G03810.1; AT5G03810.1; AT5G03810.
DR GeneID; 831715; -.
DR Gramene; AT5G03810.1; AT5G03810.1; AT5G03810.
DR KEGG; ath:AT5G03810; -.
DR Araport; AT5G03810; -.
DR TAIR; locus:2150555; AT5G03810.
DR eggNOG; KOG0017; Eukaryota.
DR HOGENOM; CLU_015101_0_1_1; -.
DR InParanoid; Q9FFN0; -.
DR OMA; NGFFETR; -.
DR OrthoDB; 704138at2759; -.
DR PhylomeDB; Q9FFN0; -.
DR BioCyc; ARA:AT5G03810-MON; -.
DR PRO; PR:Q9FFN0; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; Q9FFN0; baseline and differential.
DR Genevisible; Q9FFN0; AT.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0016298; F:lipase activity; IEA:InterPro.
DR GO; GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW.
DR CDD; cd01837; SGNH_plant_lipase_like; 1.
DR Gene3D; 3.40.50.1110; -; 1.
DR InterPro; IPR001087; GDSL.
DR InterPro; IPR008265; Lipase_GDSL_AS.
DR InterPro; IPR036514; SGNH_hydro_sf.
DR InterPro; IPR035669; SGNH_plant_lipase-like.
DR Pfam; PF00657; Lipase_GDSL; 1.
DR PROSITE; PS01098; LIPASE_GDSL_SER; 1.
PE 3: Inferred from homology;
KW Glycoprotein; Hydrolase; Lipid degradation; Lipid metabolism;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1..24
FT /evidence="ECO:0000255"
FT CHAIN 25..353
FT /note="GDSL esterase/lipase At5g03810"
FT /id="PRO_0000367412"
FT ACT_SITE 37
FT /note="Nucleophile"
FT /evidence="ECO:0000250"
FT ACT_SITE 328
FT /evidence="ECO:0000250"
FT ACT_SITE 331
FT /evidence="ECO:0000250"
FT CARBOHYD 100
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 255
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 256
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 260
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 320
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VARIANT 98
FT /note="E -> D (in strain: cv. Bla-10, cv. Chi-1, cv. Cvi-0,
FT cv. Di-G, cv. Gr-3, cv. Landsberg erecta, cv. Li-3, cv. Mt-
FT 0, cv. PHW-1 and cv. Sha)"
FT /evidence="ECO:0000269|PubMed:18273534"
FT VARIANT 150
FT /note="K -> T (in strain: cv. Bla-10)"
FT /evidence="ECO:0000269|PubMed:18273534"
FT VARIANT 193
FT /note="H -> R (in strain: cv. Bla-10, cv. Chi-1, cv. Co-1,
FT cv. Cvi-0, cv. Di-G, cv. Gr-3, cv. Landsberg erecta, cv.
FT Li-3, cv. Mt-0, cv. PHW-32 and cv. Sha)"
FT /evidence="ECO:0000269|PubMed:18273534"
SQ SEQUENCE 353 AA; 38355 MW; 0668FE27B79B265B CRC64;
MKMFITMSMC LSVIACFYAG VGTGETLVPA LIIMGDSVVD AGNNNHRITL VKANFPPYGR
DFVAHSATGR FSNGKLATDF TAENLGFTSY PVAYLSQEAN ETNLLTGANF ASGASGFDDA
TAIFYNAITL SQQLKNYKEY QNKVTNIVGK ERANEIFSGA IHLLSTGSSD FLQSYYINPI
LNRIFTPDQY SDHLLRSYST FVQNLYGLGA RRIGVTTLPP LGCLPAAITL FGGVGNNMCV
ERLNQDAVSF NTKLNNTSIN LTNNLPGLKL VVFDIYNPLL NMVINPVEYG FFESRRACCG
TGTMETSFLC NALSVGTCSN ATNYVFWDGF HPSEAANRVI ANNLLVQGIP LIS