GDL79_ARATH
ID GDL79_ARATH Reviewed; 366 AA.
AC Q8LB81; A8MQ91;
DT 24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 106.
DE RecName: Full=GDSL esterase/lipase At5g33370;
DE EC=3.1.1.-;
DE AltName: Full=Extracellular lipase At5g33370;
DE Flags: Precursor;
GN OrderedLocusNames=At5g33370; ORFNames=F19N2.90;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130714; DOI=10.1038/35048507;
RA Tabata S., Kaneko T., Nakamura Y., Kotani H., Kato T., Asamizu E.,
RA Miyajima N., Sasamoto S., Kimura T., Hosouchi T., Kawashima K., Kohara M.,
RA Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Naruo K.,
RA Okumura S., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M.,
RA Yasuda M., Sato S., de la Bastide M., Huang E., Spiegel L., Gnoj L.,
RA O'Shaughnessy A., Preston R., Habermann K., Murray J., Johnson D.,
RA Rohlfing T., Nelson J., Stoneking T., Pepin K., Spieth J., Sekhon M.,
RA Armstrong J., Becker M., Belter E., Cordum H., Cordes M., Courtney L.,
RA Courtney W., Dante M., Du H., Edwards J., Fryman J., Haakensen B.,
RA Lamar E., Latreille P., Leonard S., Meyer R., Mulvaney E., Ozersky P.,
RA Riley A., Strowmatt C., Wagner-McPherson C., Wollam A., Yoakum M., Bell M.,
RA Dedhia N., Parnell L., Shah R., Rodriguez M., Hoon See L., Vil D.,
RA Baker J., Kirchoff K., Toth K., King L., Bahret A., Miller B., Marra M.A.,
RA Martienssen R., McCombie W.R., Wilson R.K., Murphy G., Bancroft I.,
RA Volckaert G., Wambutt R., Duesterhoeft A., Stiekema W., Pohl T.,
RA Entian K.-D., Terryn N., Hartley N., Bent E., Johnson S., Langham S.-A.,
RA McCullagh B., Robben J., Grymonprez B., Zimmermann W., Ramsperger U.,
RA Wedler H., Balke K., Wedler E., Peters S., van Staveren M., Dirkse W.,
RA Mooijman P., Klein Lankhorst R., Weitzenegger T., Bothe G., Rose M.,
RA Hauf J., Berneiser S., Hempel S., Feldpausch M., Lamberth S.,
RA Villarroel R., Gielen J., Ardiles W., Bents O., Lemcke K., Kolesov G.,
RA Mayer K.F.X., Rudd S., Schoof H., Schueller C., Zaccaria P., Mewes H.-W.,
RA Bevan M., Fransz P.F.;
RT "Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana.";
RL Nature 408:823-826(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RA Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
RA Feldmann K.A.;
RT "Full-length cDNA from Arabidopsis thaliana.";
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP REVIEW.
RX PubMed=15522763; DOI=10.1016/j.plipres.2004.09.002;
RA Akoh C.C., Lee G.-C., Liaw Y.-C., Huang T.-H., Shaw J.-F.;
RT "GDSL family of serine esterases/lipases.";
RL Prog. Lipid Res. 43:534-552(2004).
RN [6]
RP GENE FAMILY.
RX PubMed=18819574; DOI=10.3923/pjbs.2008.763.767;
RA Ling H.;
RT "Sequence analysis of GDSL lipase gene family in Arabidopsis thaliana.";
RL Pak. J. Biol. Sci. 11:763-767(2008).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8LB81-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8LB81-2; Sequence=VSP_036696;
CC -!- SIMILARITY: Belongs to the 'GDSL' lipolytic enzyme family.
CC {ECO:0000305}.
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DR EMBL; AC051625; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CP002688; AED93898.1; -; Genomic_DNA.
DR EMBL; CP002688; AED93899.1; -; Genomic_DNA.
DR EMBL; BT004124; AAO42146.1; -; mRNA.
DR EMBL; BT004981; AAO50514.1; -; mRNA.
DR EMBL; AY087366; AAM64916.1; -; mRNA.
DR RefSeq; NP_001078631.1; NM_001085162.1. [Q8LB81-2]
DR RefSeq; NP_198322.1; NM_122861.4. [Q8LB81-1]
DR AlphaFoldDB; Q8LB81; -.
DR SMR; Q8LB81; -.
DR STRING; 3702.AT5G33370.1; -.
DR PaxDb; Q8LB81; -.
DR PRIDE; Q8LB81; -.
DR ProteomicsDB; 221989; -. [Q8LB81-1]
DR EnsemblPlants; AT5G33370.1; AT5G33370.1; AT5G33370. [Q8LB81-1]
DR EnsemblPlants; AT5G33370.2; AT5G33370.2; AT5G33370. [Q8LB81-2]
DR GeneID; 833315; -.
DR Gramene; AT5G33370.1; AT5G33370.1; AT5G33370. [Q8LB81-1]
DR Gramene; AT5G33370.2; AT5G33370.2; AT5G33370. [Q8LB81-2]
DR KEGG; ath:AT5G33370; -.
DR Araport; AT5G33370; -.
DR TAIR; locus:2145969; AT5G33370.
DR eggNOG; ENOG502QQP0; Eukaryota.
DR HOGENOM; CLU_015101_0_0_1; -.
DR InParanoid; Q8LB81; -.
DR OMA; RECEAKP; -.
DR OrthoDB; 704138at2759; -.
DR PhylomeDB; Q8LB81; -.
DR BioCyc; ARA:AT5G33370-MON; -.
DR PRO; PR:Q8LB81; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; Q8LB81; baseline and differential.
DR Genevisible; Q8LB81; AT.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0016788; F:hydrolase activity, acting on ester bonds; IEA:InterPro.
DR GO; GO:0042335; P:cuticle development; IMP:TAIR.
DR GO; GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW.
DR CDD; cd01837; SGNH_plant_lipase_like; 1.
DR Gene3D; 3.40.50.1110; -; 1.
DR InterPro; IPR001087; GDSL.
DR InterPro; IPR036514; SGNH_hydro_sf.
DR InterPro; IPR035669; SGNH_plant_lipase-like.
DR Pfam; PF00657; Lipase_GDSL; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Glycoprotein; Hydrolase; Lipid degradation;
KW Lipid metabolism; Reference proteome; Secreted; Signal.
FT SIGNAL 1..28
FT /evidence="ECO:0000255"
FT CHAIN 29..366
FT /note="GDSL esterase/lipase At5g33370"
FT /id="PRO_0000367419"
FT ACT_SITE 37
FT /note="Nucleophile"
FT /evidence="ECO:0000250"
FT ACT_SITE 327
FT /evidence="ECO:0000250"
FT ACT_SITE 330
FT /evidence="ECO:0000250"
FT CARBOHYD 118
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 355
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VAR_SEQ 291..366
FT /note="FVTSKVACCGQGPYNGIGLCTPLSNLCPNRDLFAFWDPFHPSEKASRIIAQQ
FT ILNGSPEYMHPMNLSTILTVDSMT -> GLLWTRAVQWDRAMHSIIKSLPKQRSLCLLG
FT SFSPIRKSK (in isoform 2)"
FT /evidence="ECO:0000305"
FT /id="VSP_036696"
SQ SEQUENCE 366 AA; 40359 MW; B20375B4CCB87CD1 CRC64;
MTNSVAKLAL LGFCILQVTS LLVPQANARA FLVFGDSLVD NGNNDFLATT ARADNYPYGI
DFPTHRPTGR FSNGLNIPDL ISEHLGQESP MPYLSPMLKK DKLLRGANFA SAGIGILNDT
GIQFLNIIRI TKQLEYFEQY KVRVSGLVGE EEMNRLVNGA LVLITLGGND FVNNYYLVPF
SARSRQFSLP DYVVFVISEY RKVLRKMYDL GARRVLVTGT GPMGCVPAEL AQRSRNGECA
TELQRAASLF NPQLIQMITD LNNEVGSSAF IAANTQQMHM DFISDPQAYG FVTSKVACCG
QGPYNGIGLC TPLSNLCPNR DLFAFWDPFH PSEKASRIIA QQILNGSPEY MHPMNLSTIL
TVDSMT
