GDL8_ARATH
ID GDL8_ARATH Reviewed; 403 AA.
AC Q8RXT9; Q9FXJ3;
DT 24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT 24-MAR-2009, sequence version 2.
DT 03-AUG-2022, entry version 99.
DE RecName: Full=GDSL esterase/lipase At1g28590;
DE EC=3.1.1.-;
DE AltName: Full=Extracellular lipase At1g28590;
DE Flags: Precursor;
GN OrderedLocusNames=At1g28590; ORFNames=F1K23.17;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 161-403.
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP REVIEW.
RX PubMed=15522763; DOI=10.1016/j.plipres.2004.09.002;
RA Akoh C.C., Lee G.-C., Liaw Y.-C., Huang T.-H., Shaw J.-F.;
RT "GDSL family of serine esterases/lipases.";
RL Prog. Lipid Res. 43:534-552(2004).
RN [5]
RP GENE FAMILY.
RX PubMed=18819574; DOI=10.3923/pjbs.2008.763.767;
RA Ling H.;
RT "Sequence analysis of GDSL lipase gene family in Arabidopsis thaliana.";
RL Pak. J. Biol. Sci. 11:763-767(2008).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the 'GDSL' lipolytic enzyme family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAF24548.2; Type=Erroneous gene model prediction; Note=The predicted gene At1g28590 has been split into 2 genes: At1g28590 and At1g28600.; Evidence={ECO:0000305};
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DR EMBL; AC007508; AAF24548.2; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002684; AEE30998.1; -; Genomic_DNA.
DR EMBL; AY080675; AAL86351.1; -; mRNA.
DR RefSeq; NP_174181.1; NM_102627.3.
DR AlphaFoldDB; Q8RXT9; -.
DR SMR; Q8RXT9; -.
DR STRING; 3702.AT1G28590.1; -.
DR PaxDb; Q8RXT9; -.
DR PRIDE; Q8RXT9; -.
DR ProteomicsDB; 221996; -.
DR EnsemblPlants; AT1G28590.1; AT1G28590.1; AT1G28590.
DR GeneID; 839759; -.
DR Gramene; AT1G28590.1; AT1G28590.1; AT1G28590.
DR KEGG; ath:AT1G28590; -.
DR Araport; AT1G28590; -.
DR TAIR; locus:2018743; AT1G28590.
DR eggNOG; ENOG502QSMM; Eukaryota.
DR HOGENOM; CLU_015101_2_1_1; -.
DR InParanoid; Q8RXT9; -.
DR OMA; SNKQAYD; -.
DR OrthoDB; 704138at2759; -.
DR PhylomeDB; Q8RXT9; -.
DR BioCyc; ARA:AT1G28590-MON; -.
DR PRO; PR:Q8RXT9; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q8RXT9; baseline and differential.
DR Genevisible; Q8RXT9; AT.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0016788; F:hydrolase activity, acting on ester bonds; IEA:InterPro.
DR GO; GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW.
DR CDD; cd01837; SGNH_plant_lipase_like; 1.
DR Gene3D; 3.40.50.1110; -; 1.
DR InterPro; IPR001087; GDSL.
DR InterPro; IPR036514; SGNH_hydro_sf.
DR InterPro; IPR035669; SGNH_plant_lipase-like.
DR Pfam; PF00657; Lipase_GDSL; 1.
PE 2: Evidence at transcript level;
KW Glycoprotein; Hydrolase; Lipid degradation; Lipid metabolism;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1..27
FT /evidence="ECO:0000255"
FT CHAIN 28..403
FT /note="GDSL esterase/lipase At1g28590"
FT /id="PRO_0000367350"
FT ACT_SITE 43
FT /note="Nucleophile"
FT /evidence="ECO:0000250"
FT ACT_SITE 346
FT /evidence="ECO:0000250"
FT ACT_SITE 349
FT /evidence="ECO:0000250"
FT CARBOHYD 139
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 323
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 403 AA; 44811 MW; 0B869AC23AA2F0B1 CRC64;
MASLDSLPAM KLVRFILSTL LVTSVNSQTQ CRNFKSIISF GDSIADTGNL LGLSDPNDLP
ASAFPPYGET FFHHPTGRYS DGRLIIDFIA EFLGFPLVPP FYGCQNANFK KGVNFAVAGA
TALEPSFLEE RGIHSTITNV SLSVQLRSFT ESLPNLCGSP SDCRDMIENA LILMGEIGGN
DYNFALFQRK PVKEVEELVP FVIATISSAI TELVCMGGRT FLVPGNFPIG YSASYLTLYK
TSNKEEYDPL TGCLKWLNDF SEYYNKQLQE ELNGLRKLYP HVNIIYADYY NALLRLFQEP
AKFGFMNRPL PACCGVGGSY NFNFSRRCGS VGVEYCDDPS QYVNYDGIHM TEAAYRLISE
GLLKGPYAIP PFKWSCLSSE IMNKMSLDTQ ILDEQLLQGC LKV
