GDL9_ARATH
ID GDL9_ARATH Reviewed; 393 AA.
AC Q94F40; A0A2H1ZEC6; Q2V4K5; Q8LAS3; Q9FXJ3;
DT 24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 112.
DE RecName: Full=GDSL esterase/lipase At1g28600;
DE EC=3.1.1.-;
DE AltName: Full=Extracellular lipase At1g28600;
DE Flags: Precursor;
GN OrderedLocusNames=At1g28600; ORFNames=F1K23.6;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RA Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
RA Feldmann K.A.;
RT "Full-length cDNA from Arabidopsis thaliana.";
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP REVIEW.
RX PubMed=15522763; DOI=10.1016/j.plipres.2004.09.002;
RA Akoh C.C., Lee G.-C., Liaw Y.-C., Huang T.-H., Shaw J.-F.;
RT "GDSL family of serine esterases/lipases.";
RL Prog. Lipid Res. 43:534-552(2004).
RN [6]
RP GENE FAMILY.
RX PubMed=18819574; DOI=10.3923/pjbs.2008.763.767;
RA Ling H.;
RT "Sequence analysis of GDSL lipase gene family in Arabidopsis thaliana.";
RL Pak. J. Biol. Sci. 11:763-767(2008).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q94F40-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q94F40-2; Sequence=VSP_036688;
CC -!- SIMILARITY: Belongs to the 'GDSL' lipolytic enzyme family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAF24548.2; Type=Erroneous gene model prediction; Note=The predicted gene At1g28590 has been split into 2 genes: At1g28590 and At1g28600.; Evidence={ECO:0000305};
CC Sequence=AEE31000.2; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AC007508; AAF24548.2; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002684; AEE31000.2; ALT_SEQ; Genomic_DNA.
DR EMBL; AF385739; AAK60329.1; -; mRNA.
DR EMBL; AY133675; AAM91505.1; -; mRNA.
DR EMBL; AY087645; AAM65183.1; -; mRNA.
DR RefSeq; NP_001319101.1; NM_001332821.1.
DR RefSeq; NP_174182.1; NM_102628.4. [Q94F40-1]
DR AlphaFoldDB; Q94F40; -.
DR SMR; Q94F40; -.
DR STRING; 3702.AT1G28600.1; -.
DR PaxDb; Q94F40; -.
DR PRIDE; Q94F40; -.
DR ProteomicsDB; 221998; -. [Q94F40-1]
DR EnsemblPlants; AT1G28600.1; AT1G28600.1; AT1G28600. [Q94F40-1]
DR GeneID; 839760; -.
DR Gramene; AT1G28600.1; AT1G28600.1; AT1G28600. [Q94F40-1]
DR KEGG; ath:AT1G28600; -.
DR Araport; AT1G28600; -.
DR TAIR; locus:2018753; AT1G28600.
DR eggNOG; ENOG502QSMM; Eukaryota.
DR HOGENOM; CLU_015101_2_1_1; -.
DR InParanoid; Q94F40; -.
DR OMA; ACENPAQ; -.
DR PhylomeDB; Q94F40; -.
DR BioCyc; ARA:AT1G28600-MON; -.
DR PRO; PR:Q94F40; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q94F40; baseline and differential.
DR Genevisible; Q94F40; AT.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0016788; F:hydrolase activity, acting on ester bonds; IEA:InterPro.
DR GO; GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW.
DR CDD; cd01837; SGNH_plant_lipase_like; 1.
DR Gene3D; 3.40.50.1110; -; 1.
DR InterPro; IPR001087; GDSL.
DR InterPro; IPR036514; SGNH_hydro_sf.
DR InterPro; IPR035669; SGNH_plant_lipase-like.
DR Pfam; PF00657; Lipase_GDSL; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Glycoprotein; Hydrolase; Lipid degradation;
KW Lipid metabolism; Reference proteome; Secreted; Signal.
FT SIGNAL 1..22
FT /evidence="ECO:0000255"
FT CHAIN 23..393
FT /note="GDSL esterase/lipase At1g28600"
FT /id="PRO_0000367351"
FT ACT_SITE 38
FT /note="Nucleophile"
FT /evidence="ECO:0000250"
FT ACT_SITE 340
FT /evidence="ECO:0000250"
FT ACT_SITE 343
FT /evidence="ECO:0000250"
FT CARBOHYD 133
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 317
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 382
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VAR_SEQ 299..393
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000305"
FT /id="VSP_036688"
FT CONFLICT 27
FT /note="P -> R (in Ref. 4; AAM65183)"
FT /evidence="ECO:0000305"
FT CONFLICT 137
FT /note="G -> R (in Ref. 4; AAM65183)"
FT /evidence="ECO:0000305"
FT CONFLICT 244
FT /note="S -> T (in Ref. 4; AAM65183)"
FT /evidence="ECO:0000305"
FT CONFLICT 264
FT /note="V -> A (in Ref. 4; AAM65183)"
FT /evidence="ECO:0000305"
FT CONFLICT 301
FT /note="E -> D (in Ref. 4; AAM65183)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 393 AA; 43610 MW; F08C7085A27E8A15 CRC64;
MASLDSLVIF LFSTLFVTIV SSETPCPNFK SIISFGDSIA DTGNLVGLSD RNQLPVTAFP
PYGETFFHHP TGRSCDGRII MDFIAEFVGL PYVPPYFGSK NRNFDKGVNF AVAGATALKS
SFLKKRGIQP HTNVSLGVQL KSFKKSLPNL CGSPSDCRDM IGNALILMGE IGGNDYNFPF
FNRKPVKEVE ELVPFVIASI SSTITELIGM GGKTFLVPGE FPIGCSVVYL TLYKTSNKDE
YDPSTGCLKW LNKFGEYHSE KLKVELNRLR KLYPHVNIIY ADYYNSLLRI FKEPAKFGFM
ERPFPACCGI GGPYNFNFTR KCGSVGVKSC KDPSKYVGWD GVHMTEAAYK WIADGILNGP
YANPPFDRSC LRSEIKKESL YNQSTLTQAC VKL
