GDL_DROME
ID GDL_DROME Reviewed; 194 AA.
AC P22468; Q4V3J8; Q9U5V5; Q9VUP2;
DT 01-AUG-1991, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2000, sequence version 3.
DT 03-AUG-2022, entry version 126.
DE RecName: Full=Gonadal protein gdl;
GN Name=gdl; ORFNames=CG7268;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], TISSUE SPECIFICITY, AND DEVELOPMENTAL
RP STAGE.
RC TISSUE=Embryo, Ovary, and Testis;
RX PubMed=2497054; DOI=10.1101/gad.3.2.232;
RA Schulz R.A., Butler B.A.;
RT "Overlapping genes of Drosophila melanogaster: organization of the z600-
RT gonadal-Eip28/29 gene cluster.";
RL Genes Dev. 3:232-242(1989).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley;
RA Stapleton M., Carlson J.W., Chavez C., Frise E., George R.A., Pacleb J.M.,
RA Park S., Wan K.H., Yu C., Celniker S.E.;
RL Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP CHARACTERIZATION.
RX PubMed=2117521; DOI=10.1242/dev.108.4.613;
RA Schulz R.A., Miksch J.L., Xie X.L., Cornish J.A., Galewsky S.;
RT "Expression of the Drosophila gonadal gene: alternative promoters control
RT the germ-line expression of monocistronic and bicistronic gene
RT transcripts.";
RL Development 108:613-622(1990).
CC -!- TISSUE SPECIFICITY: In stage 6-14 egg chamber nurse cells and oocytes
CC of adult females and spermatocyte cysts and bundles of maturing sperm
CC of larval, pupal and adult males. {ECO:0000269|PubMed:2497054}.
CC -!- DEVELOPMENTAL STAGE: During oogenesis and spermatogenesis.
CC {ECO:0000269|PubMed:2497054}.
CC -!- SIMILARITY: Belongs to the gonadal family. {ECO:0000305}.
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DR EMBL; X58286; CAB58351.1; -; Genomic_DNA.
DR EMBL; AE014296; AAF49633.1; -; Genomic_DNA.
DR EMBL; BT023358; AAY55774.1; -; mRNA.
DR PIR; S22881; S22881.
DR RefSeq; NP_001027127.1; NM_001031956.2.
DR RefSeq; NP_001261877.1; NM_001274948.1.
DR RefSeq; NP_001287071.1; NM_001300142.1.
DR AlphaFoldDB; P22468; -.
DR STRING; 7227.FBpp0306207; -.
DR PaxDb; P22468; -.
DR DNASU; 3772583; -.
DR EnsemblMetazoa; FBtr0091757; FBpp0075305; FBgn0001099.
DR EnsemblMetazoa; FBtr0334082; FBpp0306207; FBgn0001099.
DR EnsemblMetazoa; FBtr0346516; FBpp0312134; FBgn0001099.
DR GeneID; 3772583; -.
DR KEGG; dme:Dmel_CG33756; -.
DR UCSC; CG33756-RA; d. melanogaster.
DR CTD; 3772583; -.
DR FlyBase; FBgn0001099; gdl.
DR VEuPathDB; VectorBase:FBgn0001099; -.
DR eggNOG; KOG4810; Eukaryota.
DR GeneTree; ENSGT00390000017663; -.
DR HOGENOM; CLU_096921_0_0_1; -.
DR InParanoid; P22468; -.
DR OMA; CVLNESI; -.
DR PhylomeDB; P22468; -.
DR BioGRID-ORCS; 3772583; 0 hits in 3 CRISPR screens.
DR ChiTaRS; Arp1; fly.
DR GenomeRNAi; 3772583; -.
DR PRO; PR:P22468; -.
DR Proteomes; UP000000803; Chromosome 3L.
DR Bgee; FBgn0001099; Expressed in testis and 10 other tissues.
DR ExpressionAtlas; P22468; baseline and differential.
DR Genevisible; P22468; DM.
DR InterPro; IPR010849; Gonadal.
DR PANTHER; PTHR13054; PTHR13054; 1.
DR Pfam; PF07324; DGCR6; 1.
PE 1: Evidence at protein level;
KW Reference proteome.
FT CHAIN 1..194
FT /note="Gonadal protein gdl"
FT /id="PRO_0000070263"
FT CONFLICT 21
FT /note="Y -> H (in Ref. 1; CAB58351)"
FT /evidence="ECO:0000305"
FT CONFLICT 162..163
FT /note="GF -> V (in Ref. 1; CAB58351)"
FT /evidence="ECO:0000305"
FT CONFLICT 185..188
FT /note="LSRL -> FTAV (in Ref. 1; CAB58351)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 194 AA; 22653 MW; 48BAF262DEE891C0 CRC64;
MADIPATSEG SANTSEAVVE YQQPTPEFLQ RKIYFLVDQL RTYHSELPEN LQTRISYDLL
TELANCVLND GIFVIVKALM ELQHETERHL IKIRMQAENE YEIEVAEWRS KIKDPEELRH
ILGLMKIKHT KKLHESDTKI IEILDQKVND QQSTLQKAGV PGFYVTENPK EIKIQMFLLD
FILRLSRLKY EPGK
