GDNF_XENLA
ID GDNF_XENLA Reviewed; 227 AA.
AC Q06PM8;
DT 26-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT 31-OCT-2006, sequence version 1.
DT 03-AUG-2022, entry version 56.
DE RecName: Full=Glial cell line-derived neurotrophic factor;
DE Short=xGDNF;
DE Flags: Precursor;
GN Name=gdnf {ECO:0000312|EMBL:ABG77975.1};
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355;
RN [1] {ECO:0000305, ECO:0000312|EMBL:ABG77975.1}
RP NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
RX PubMed=17049928; DOI=10.1016/j.modgep.2006.08.005;
RA Kyuno J., Jones E.A.;
RT "GDNF expression during Xenopus development.";
RL Gene Expr. Patterns 7:313-317(2007).
CC -!- FUNCTION: Neurotrophic factor that enhances survival and morphological
CC differentiation of dopaminergic neurons and increases their high-
CC affinity dopamine uptake. {ECO:0000250|UniProtKB:Q07731}.
CC -!- SUBUNIT: Homodimer; disulfide-linked. {ECO:0000250|UniProtKB:Q07731}.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- TISSUE SPECIFICITY: From stage 22, expressed in somites and the
CC pronephros. At stage 24 and 26, expressed in the pharyngeal arches I-
CC III. At stage 31, expression in the eye, central nervous system and
CC pharyngeal arches IV and V increases. Up to stage 34, expression
CC becomes intense at the oral cavity and lateral line structures. At this
CC stage, expression weakens in the pharyngeal arches, and increases in
CC the epibranchial arches. Expressed in the digestive tract in stage 34
CC embryos. {ECO:0000269|PubMed:17049928}.
CC -!- DEVELOPMENTAL STAGE: First expressed at a low level at stage 12, with
CC expression gradually increasing up to stage 22. From stage 24,
CC expression increases sharply and continues at a similar level as
CC development progresses through the tadpole stages.
CC {ECO:0000269|PubMed:17049928}.
CC -!- SIMILARITY: Belongs to the TGF-beta family. GDNF subfamily.
CC {ECO:0000255}.
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DR EMBL; DQ779994; ABG77975.1; -; mRNA.
DR RefSeq; NP_001090196.1; NM_001096727.1.
DR AlphaFoldDB; Q06PM8; -.
DR SMR; Q06PM8; -.
DR GeneID; 779087; -.
DR KEGG; xla:779087; -.
DR CTD; 779087; -.
DR Xenbase; XB-GENE-865016; gdnf.L.
DR OrthoDB; 1373773at2759; -.
DR Proteomes; UP000186698; Chromosome 1L.
DR Bgee; 779087; Expressed in lung and 7 other tissues.
DR GO; GO:0005576; C:extracellular region; ISS:UniProtKB.
DR GO; GO:0030116; F:glial cell-derived neurotrophic factor receptor binding; IEA:InterPro.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR GO; GO:0042803; F:protein homodimerization activity; ISS:UniProtKB.
DR GO; GO:0030971; F:receptor tyrosine kinase binding; IEA:InterPro.
DR GO; GO:0001658; P:branching involved in ureteric bud morphogenesis; ISS:UniProtKB.
DR GO; GO:0048484; P:enteric nervous system development; ISS:UniProtKB.
DR GO; GO:0001656; P:metanephros development; ISS:UniProtKB.
DR GO; GO:0048255; P:mRNA stabilization; ISS:UniProtKB.
DR GO; GO:0043524; P:negative regulation of neuron apoptotic process; ISS:UniProtKB.
DR GO; GO:0001755; P:neural crest cell migration; ISS:UniProtKB.
DR GO; GO:0031175; P:neuron projection development; ISS:UniProtKB.
DR GO; GO:0030432; P:peristalsis; ISS:UniProtKB.
DR GO; GO:0090190; P:positive regulation of branching involved in ureteric bud morphogenesis; ISS:UniProtKB.
DR GO; GO:0032770; P:positive regulation of monooxygenase activity; ISS:UniProtKB.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISS:UniProtKB.
DR GO; GO:0072107; P:positive regulation of ureteric bud formation; ISS:UniProtKB.
DR GO; GO:0021784; P:postganglionic parasympathetic fiber development; ISS:UniProtKB.
DR GO; GO:0051584; P:regulation of dopamine uptake involved in synaptic transmission; ISS:UniProtKB.
DR GO; GO:0060688; P:regulation of morphogenesis of a branching structure; ISS:UniProtKB.
DR GO; GO:0048485; P:sympathetic nervous system development; ISS:UniProtKB.
DR Gene3D; 2.10.90.10; -; 1.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR016649; GDNF.
DR InterPro; IPR043401; GDNF_fam.
DR InterPro; IPR001839; TGF-b_C.
DR PANTHER; PTHR12173; PTHR12173; 1.
DR PANTHER; PTHR12173:SF1; PTHR12173:SF1; 1.
DR Pfam; PF00019; TGF_beta; 1.
DR PIRSF; PIRSF016238; GDNF; 1.
DR SMART; SM00204; TGFB; 1.
DR SUPFAM; SSF57501; SSF57501; 1.
DR PROSITE; PS51362; TGF_BETA_2; 1.
PE 2: Evidence at transcript level;
KW Cleavage on pair of basic residues; Disulfide bond; Glycoprotein;
KW Growth factor; Reference proteome; Secreted; Signal.
FT SIGNAL 1..19
FT /evidence="ECO:0000255"
FT PROPEP 20..93
FT /evidence="ECO:0000250|UniProtKB:Q07731"
FT /id="PRO_0000292934"
FT CHAIN 96..227
FT /note="Glial cell line-derived neurotrophic factor"
FT /evidence="ECO:0000255"
FT /id="PRO_0000292935"
FT REGION 32..61
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 93..113
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 142
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 178
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 134..195
FT /evidence="ECO:0000250|UniProtKB:Q07731"
FT DISULFID 161..224
FT /evidence="ECO:0000250|UniProtKB:Q07731"
FT DISULFID 165..226
FT /evidence="ECO:0000250|UniProtKB:Q07731"
FT DISULFID 194
FT /note="Interchain"
FT /evidence="ECO:0000250|UniProtKB:Q07731"
SQ SEQUENCE 227 AA; 25771 MW; 68BFA7EE9EE52C0A CRC64;
MKLWAILAVC ILLLSSVSSI PLPSNWLAGK KRSHLPDPQE GEDQVFGMDG AVPEDPTANM
APQDQQTYTE IPDDYPDQFD DVLEFIQDTI KRLKRSSNKQ PPSRRDRGRQ SLAANTQISS
KKTVKDRKRK NKGCVLREIH LNVTDLGLGY ETKEELKFRY CSGSCNNPET TYDQILKNLT
IRKKLVNDKV KQACCRPIAF DDDLSFLDDN LVYHTLKQHS AKKCGCI
