ID   ALP16_SCHPO             Reviewed;         759 AA.
AC   P87244;
DT   06-DEC-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1997, sequence version 1.
DT   25-MAY-2022, entry version 122.
DE   RecName: Full=Spindle pole body component alp16;
DE   AltName: Full=Altered polarity protein 16;
GN   Name=alp16; ORFNames=SPCC4G3.19;
OS   Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=284812;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, SUBUNIT, AND SUBCELLULAR
RP   LOCATION.
RX   PubMed=12134075; DOI=10.1091/mbc.02-01-0603;
RA   Fujita A., Vardy L., Garcia M.-I., Toda T.;
RT   "A fourth component of the fission yeast gamma-tubulin complex, Alp16, is
RT   required for cytoplasmic microtubule integrity and becomes indispensable
RT   when gamma-tubulin function is compromised.";
RL   Mol. Biol. Cell 13:2360-2373(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA   Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA   Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA   Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA   Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA   Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA   O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA   Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA   Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA   Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA   Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA   Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA   Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA   Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA   Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA   Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA   Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA   Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA   del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA   Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA   Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA   Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
CC   -!- FUNCTION: Component of the gamma tubule complex that is required for
CC       the regulation of both interphase microtubules and mitotic bipolar
CC       spindles. {ECO:0000269|PubMed:12134075}.
CC   -!- SUBUNIT: Interacts with gamma-tubulin. {ECO:0000269|PubMed:12134075}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC       center, spindle pole body {ECO:0000269|PubMed:12134075}. Note=And the
CC       microtubule organizing center (MTOC).
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DR   EMBL; AB074978; BAB79248.1; -; Genomic_DNA.
DR   EMBL; CU329672; CAB09763.1; -; Genomic_DNA.
DR   PIR; T41357; T41357.
DR   RefSeq; NP_587819.1; NM_001022812.2.
DR   AlphaFoldDB; P87244; -.
DR   BioGRID; 275876; 59.
DR   STRING; 4896.SPCC4G3.19.1; -.
DR   MaxQB; P87244; -.
DR   PaxDb; P87244; -.
DR   PRIDE; P87244; -.
DR   EnsemblFungi; SPCC4G3.19.1; SPCC4G3.19.1:pep; SPCC4G3.19.
DR   GeneID; 2539309; -.
DR   KEGG; spo:SPCC4G3.19; -.
DR   PomBase; SPCC4G3.19; alp16.
DR   VEuPathDB; FungiDB:SPCC4G3.19; -.
DR   HOGENOM; CLU_374751_0_0_1; -.
DR   OMA; MNVGRKS; -.
DR   PRO; PR:P87244; -.
DR   Proteomes; UP000002485; Chromosome III.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0000923; C:equatorial microtubule organizing center; IDA:PomBase.
DR   GO; GO:0000930; C:gamma-tubulin complex; IDA:PomBase.
DR   GO; GO:0000931; C:gamma-tubulin large complex; IDA:PomBase.
DR   GO; GO:0008275; C:gamma-tubulin small complex; IDA:PomBase.
DR   GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR   GO; GO:0044732; C:mitotic spindle pole body; HDA:PomBase.
DR   GO; GO:0000922; C:spindle pole; IEA:InterPro.
DR   GO; GO:0043015; F:gamma-tubulin binding; IBA:GO_Central.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0031122; P:cytoplasmic microtubule organization; IMP:PomBase.
DR   GO; GO:0051321; P:meiotic cell cycle; IBA:GO_Central.
DR   GO; GO:0007020; P:microtubule nucleation; IBA:GO_Central.
DR   GO; GO:0051415; P:microtubule nucleation by interphase microtubule organizing center; IGI:PomBase.
DR   GO; GO:0000278; P:mitotic cell cycle; IBA:GO_Central.
DR   GO; GO:0051225; P:spindle assembly; IBA:GO_Central.
DR   InterPro; IPR007259; GCP.
DR   PANTHER; PTHR19302; PTHR19302; 1.
PE   1: Evidence at protein level;
KW   Cell cycle; Cell division; Cytoplasm; Cytoskeleton; Microtubule; Mitosis;
KW   Reference proteome.
FT   CHAIN           1..759
FT                   /note="Spindle pole body component alp16"
FT                   /id="PRO_0000064567"
SQ   SEQUENCE   759 AA;  87236 MW;  D53A2FC71EA3A8AA CRC64;
     MDGIMKNDLL WFGNHVFDLT PNSFDSDFVE QLSKFEGKEG LKRKLFDSSE YFQNFSFQVN
     DDLLGKDVIL DISNQQLTPA VPGCETSSNS KLISASKEIT SERKRAKSSV SPSYLTDSSP
     SDLSVENKVL LTCPSWDGEN FKNLEARSPF ISEAPSRVYD YFLHNQDWSP KPLFSALQVY
     PLATIFNCVA GLPQGFESTV FPWNKTSSTF ELDPTISVSG MSDECFASIV QKFSAIGGLI
     KKALNEFSLY KTNISFYLSN FIVNGVLQYR KEFQRWLRLY EFRRFGLIGL SNFVNSFSSF
     FELISHFLIK SAQNLKGDSL LDFLFDYARS CQNTISYPIA LQCLIYCSNP YFKRLELALK
     VSCAYGHIDS SLFLSLPRFF PSELCVSIEQ CIQFLSLIRE QKEIFNKNNK EFINPLNIRF
     AYSFNDINQA CVIEERCNFS SLSFGNLEQT SVNNDSEEFE TLLAKMNMTP DFNDNLLQLK
     FTDDVRNVCP LNLNVCCCIA EPIQSFILSF LRSTYKVLKN DFQVFDLLNF FHSTFLFQNY
     EFSDNVISLL KSRRLDKSDR NELAEDLNSD DRYNFISRLK KFIFMEKEKN GLSRSLSKSI
     TFTLDSASVS EFEDVYPDLQ FQCQVIGALR ILFTDNSLNY YSKTFSYVLH LFQAQSDFES
     SVELKDRSIV TKTTIMSWSK YQGTKESLFQ FLSIYIPECM LPFTKLLKSI YSPDCPTNIQ
     NSAIKNAASV HEQCTKAIYQ KVKELFDTMK LWESSIKVS