ID   GDPD3_ARATH             Reviewed;         370 AA.
AC   Q680A6; Q6NQN1; Q9FHR6;
DT   29-OCT-2014, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 108.
DE   RecName: Full=Glycerophosphodiester phosphodiesterase GDPD3 {ECO:0000305};
DE            EC=3.1.4.46 {ECO:0000250|UniProtKB:Q9SGA2};
DE   AltName: Full=Glycerophosphodiester phosphodiesterase 3 {ECO:0000303|PubMed:21323773};
DE            Short=ATGDPD3 {ECO:0000303|PubMed:21323773};
GN   Name=GDPD3 {ECO:0000303|PubMed:21323773};
GN   OrderedLocusNames=At5g43300 {ECO:0000312|Araport:AT5G43300};
GN   ORFNames=MNL12.12 {ECO:0000312|EMBL:BAB10593.1};
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=10470850; DOI=10.1093/dnares/6.3.183;
RA   Kaneko T., Katoh T., Sato S., Nakamura Y., Asamizu E., Kotani H.,
RA   Miyajima N., Tabata S.;
RT   "Structural analysis of Arabidopsis thaliana chromosome 5. IX. Sequence
RT   features of the regions of 1,011,550 bp covered by seventeen P1 and TAC
RT   clones.";
RL   DNA Res. 6:183-195(1999).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Columbia;
RA   Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA   Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA   Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA   Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA   Shinozaki K.;
RT   "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL   Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 38-370.
RC   STRAIN=cv. Columbia;
RX   PubMed=14593172; DOI=10.1126/science.1088305;
RA   Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA   Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA   Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA   Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA   Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA   Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA   Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA   Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA   Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA   Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA   Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA   Ecker J.R.;
RT   "Empirical analysis of transcriptional activity in the Arabidopsis
RT   genome.";
RL   Science 302:842-846(2003).
RN   [5]
RP   TISSUE SPECIFICITY, INDUCTION, GENE FAMILY, AND NOMENCLATURE.
RX   PubMed=21323773; DOI=10.1111/j.1365-313x.2011.04538.x;
RA   Cheng Y., Zhou W., El Sheery N.I., Peters C., Li M., Wang X., Huang J.;
RT   "Characterization of the Arabidopsis glycerophosphodiester
RT   phosphodiesterase (GDPD) family reveals a role of the plastid-localized
RT   AtGDPD1 in maintaining cellular phosphate homeostasis under phosphate
RT   starvation.";
RL   Plant J. 66:781-795(2011).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a sn-glycero-3-phosphodiester + H2O = an alcohol + H(+) + sn-
CC         glycerol 3-phosphate; Xref=Rhea:RHEA:12969, ChEBI:CHEBI:15377,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:30879, ChEBI:CHEBI:57597,
CC         ChEBI:CHEBI:83408; EC=3.1.4.46;
CC         Evidence={ECO:0000250|UniProtKB:Q9SGA2};
CC   -!- TISSUE SPECIFICITY: Expressed in flowers and siliques.
CC       {ECO:0000269|PubMed:21323773}.
CC   -!- INDUCTION: By phosphate starvation. {ECO:0000269|PubMed:21323773}.
CC   -!- SIMILARITY: Belongs to the glycerophosphoryl diester phosphodiesterase
CC       family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAB10593.1; Type=Erroneous gene model prediction;
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DR   EMBL; AB017070; BAB10593.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; CP002688; AED94940.1; -; Genomic_DNA.
DR   EMBL; AK175961; BAD43724.1; -; mRNA.
DR   EMBL; BT010420; AAQ62421.1; -; mRNA.
DR   RefSeq; NP_199144.3; NM_123696.5.
DR   AlphaFoldDB; Q680A6; -.
DR   SMR; Q680A6; -.
DR   STRING; 3702.AT5G43300.1; -.
DR   iPTMnet; Q680A6; -.
DR   PaxDb; Q680A6; -.
DR   PRIDE; Q680A6; -.
DR   ProteomicsDB; 247116; -.
DR   EnsemblPlants; AT5G43300.1; AT5G43300.1; AT5G43300.
DR   GeneID; 834348; -.
DR   Gramene; AT5G43300.1; AT5G43300.1; AT5G43300.
DR   KEGG; ath:AT5G43300; -.
DR   Araport; AT5G43300; -.
DR   TAIR; locus:2169278; AT5G43300.
DR   eggNOG; KOG2421; Eukaryota.
DR   HOGENOM; CLU_013007_0_0_1; -.
DR   InParanoid; Q680A6; -.
DR   OMA; EGEVTIC; -.
DR   OrthoDB; 687958at2759; -.
DR   PhylomeDB; Q680A6; -.
DR   PRO; PR:Q680A6; -.
DR   Proteomes; UP000006548; Chromosome 5.
DR   ExpressionAtlas; Q680A6; baseline and differential.
DR   GO; GO:0008889; F:glycerophosphodiester phosphodiesterase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006071; P:glycerol metabolic process; IEA:UniProtKB-KW.
DR   GO; GO:0046475; P:glycerophospholipid catabolic process; IBA:GO_Central.
DR   Gene3D; 3.20.20.190; -; 1.
DR   InterPro; IPR030395; GP_PDE_dom.
DR   InterPro; IPR017946; PLC-like_Pdiesterase_TIM-brl.
DR   Pfam; PF03009; GDPD; 1.
DR   SUPFAM; SSF51695; SSF51695; 1.
DR   PROSITE; PS51704; GP_PDE; 1.
PE   2: Evidence at transcript level;
KW   Glycerol metabolism; Hydrolase; Reference proteome.
FT   CHAIN           1..370
FT                   /note="Glycerophosphodiester phosphodiesterase GDPD3"
FT                   /id="PRO_0000430609"
FT   DOMAIN          35..322
FT                   /note="GP-PDE"
SQ   SEQUENCE   370 AA;  42293 MW;  BE9F7A799F2F33EF CRC64;
     MALETMTLSL SSSAMLSSGV VEDDKKQEAI VFPKFVLMGH RGFGMNMLQS PDEKMKFIKE
     NSLLSFNVAA DFPIDFIEFD VQVTRDGCPV IFHDIFMFTQ EQGVIIEKRV TEMDLHEFLS
     YGPQRDGTNV KPMWRKTKDG RIFEWKVEKD DPLCTLEDAF LNVKHSLGFN IELKFDDNTV
     YGEGELRQTL DNILTVVNEH SKNRPIIFSS FHPDAARLIR NMQRCYPVFF LTNGGCEIYK
     DVRRNSLDEA IKLCKESGLQ GLVSEVKAIL RTPNAITRVK DSKLSLLSYG QLNNVVEVIY
     LQYLMGVEGV IVDMVKDISE AIANIEVTNE DDCEGEDERK CLIRFGEERK KVEITKDMIT
     LLNKFVPKLL