GDPD4_MACFA
ID GDPD4_MACFA Reviewed; 627 AA.
AC Q95JR7; Q95K28;
DT 03-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 03-OCT-2006, sequence version 2.
DT 03-AUG-2022, entry version 65.
DE RecName: Full=Glycerophosphodiester phosphodiesterase domain-containing protein 4;
DE EC=3.1.-.-;
GN Name=GDPD4; ORFNames=QtsA-10771, QtsA-10831;
OS Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9541;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=12498619; DOI=10.1186/1471-2164-3-36;
RA Osada N., Hida M., Kusuda J., Tanuma R., Hirata M., Suto Y., Hirai M.,
RA Terao K., Sugano S., Hashimoto K.;
RT "Cynomolgus monkey testicular cDNAs for discovery of novel human genes in
RT the human genome sequence.";
RL BMC Genomics 3:36-36(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 89-627.
RC TISSUE=Testis;
RA Hashimoto K., Osada N., Hida M., Kusuda J., Tanuma R., Hirai M., Terao K.,
RA Sugano S.;
RT "Isolation of novel full-length cDNA clones from macaque testis cDNA
RT libraries.";
RL Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the glycerophosphoryl diester phosphodiesterase
CC family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB62944.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=BAB63057.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AB069999; BAB62944.1; ALT_INIT; mRNA.
DR EMBL; AB070112; BAB63057.1; ALT_INIT; mRNA.
DR AlphaFoldDB; Q95JR7; -.
DR SMR; Q95JR7; -.
DR STRING; 9541.XP_005579219.1; -.
DR eggNOG; KOG2258; Eukaryota.
DR Proteomes; UP000233100; Unplaced.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0008081; F:phosphoric diester hydrolase activity; IEA:InterPro.
DR GO; GO:0006629; P:lipid metabolic process; IEA:InterPro.
DR Gene3D; 3.20.20.190; -; 1.
DR InterPro; IPR030395; GP_PDE_dom.
DR InterPro; IPR017946; PLC-like_Pdiesterase_TIM-brl.
DR Pfam; PF03009; GDPD; 1.
DR SUPFAM; SSF51695; SSF51695; 1.
DR PROSITE; PS51704; GP_PDE; 1.
PE 2: Evidence at transcript level;
KW Glycoprotein; Hydrolase; Membrane; Metal-binding; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..627
FT /note="Glycerophosphodiester phosphodiesterase domain-
FT containing protein 4"
FT /id="PRO_0000251939"
FT TOPO_DOM 1..17
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 18..38
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 39
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 40..60
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 61..69
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 70..90
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 91..107
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 108..128
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 129..162
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 163..183
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 184..468
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 469..489
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 490..627
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 198..457
FT /note="GP-PDE"
FT BINDING 230
FT /ligand="a divalent metal cation"
FT /ligand_id="ChEBI:CHEBI:60240"
FT /evidence="ECO:0000255"
FT BINDING 232
FT /ligand="a divalent metal cation"
FT /ligand_id="ChEBI:CHEBI:60240"
FT /evidence="ECO:0000255"
FT BINDING 245
FT /ligand="a divalent metal cation"
FT /ligand_id="ChEBI:CHEBI:60240"
FT /evidence="ECO:0000255"
FT CARBOHYD 308
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 397
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 627 AA; 72388 MW; 3BB5C1C331E7D753 CRC64;
MLLFLWIETS NEYFNFDWVI FLGTGYWFYW SIFILSLAGI LTAYSSLLLL LGLLLLWEGI
ELYLHLCHKI LILLVILPCV ILMFIICKFW KERWLVAGLS LQIFAPYVHL VSITVMVILF
WPVAIYVARL EREVRMRRYR MTHSEKKRLK KCNVIARLRG LQVAVGLPFL LIFLSLCLMP
LGIYSPCIQE KENLGPKPTL FGHRGAPMLG PENTMMSFEK AVEHGAHGLE TDVHLSYDRV
PFLMHDFDLR RTTNIREVQP ESAFKNPATF SWDFLSTLNA GKWFVKPELK PFYNMKPLSK
ADKERARNQS IPTLADLLTL AKKERKFVIF DLRGPPPRHP LRHTFVRQVV SVILASKIEQ
HLIFWLPAHD RRYVRSMAPG FQHVGHLVSV KTLAKNNISI INVDYKKLFP NGLRDYKAAN
IRINVYTINE PWLFSLAWCS RINSVTTDNI GLLSQLNHPH FFMTPKFYMF IWLLVDIISV
LFIVAIFCFH WRRETIKEKL FETSSTLTDT QSRSENEEDL HIAMKPARVV ESPWTLAALY
PALSKSGKEH QGRFNFAAPS KKLVPIKNAV TPLKPGKHDI QPPMPTTVFE LTQAPSRQAK
SKATFQTTLP TLKVDKPTMP SVEVPYP