ID   GDPP1_BOVIN             Reviewed;         385 AA.
AC   Q5E9T1; Q0V8C7; Q58D74;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   15-MAR-2005, sequence version 1.
DT   03-AUG-2022, entry version 80.
DE   RecName: Full=GDP-D-glucose phosphorylase 1;
DE            EC=2.7.7.78;
GN   Name=GDPGP1;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=16305752; DOI=10.1186/1471-2164-6-166;
RA   Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L.,
RA   Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L.;
RT   "Characterization of 954 bovine full-CDS cDNA sequences.";
RL   BMC Genomics 6:166-166(2005).
CC   -!- FUNCTION: Specific and highly efficient GDP-D-glucose phosphorylase
CC       regulating the levels of GDP-D-glucose in cells. {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=GDP-alpha-D-glucose + phosphate = alpha-D-glucose 1-phosphate
CC         + GDP + H(+); Xref=Rhea:RHEA:30387, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:58189, ChEBI:CHEBI:58601,
CC         ChEBI:CHEBI:62230; EC=2.7.7.78;
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- MISCELLANEOUS: The orthologs in A.thaliana are GDP-L-galactose
CC       phosphorylases catalyzing the first reaction of the Smirnoff-Wheeler
CC       pathway, the major route to ascorbate biosynthesis in plants.
CC   -!- SIMILARITY: Belongs to the GDPGP1 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAX46570.1; Type=Frameshift; Evidence={ECO:0000305};
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DR   EMBL; BT020839; AAX08856.1; -; mRNA.
DR   EMBL; BT021157; AAX31339.1; -; mRNA.
DR   EMBL; BT021160; AAX31342.1; -; mRNA.
DR   EMBL; BT021723; AAX46570.1; ALT_FRAME; mRNA.
DR   EMBL; BT026292; ABG81448.1; -; mRNA.
DR   RefSeq; NP_001015629.1; NM_001015629.1.
DR   AlphaFoldDB; Q5E9T1; -.
DR   SMR; Q5E9T1; -.
DR   STRING; 9913.ENSBTAP00000006812; -.
DR   PaxDb; Q5E9T1; -.
DR   PRIDE; Q5E9T1; -.
DR   Ensembl; ENSBTAT00000006812; ENSBTAP00000006812; ENSBTAG00000005174.
DR   GeneID; 522909; -.
DR   KEGG; bta:522909; -.
DR   CTD; 390637; -.
DR   VEuPathDB; HostDB:ENSBTAG00000005174; -.
DR   VGNC; VGNC:29314; GDPGP1.
DR   eggNOG; KOG2720; Eukaryota.
DR   GeneTree; ENSGT00390000016718; -.
DR   HOGENOM; CLU_041964_2_1_1; -.
DR   InParanoid; Q5E9T1; -.
DR   OMA; GIRVILW; -.
DR   OrthoDB; 1178383at2759; -.
DR   TreeFam; TF313615; -.
DR   Proteomes; UP000009136; Chromosome 21.
DR   Bgee; ENSBTAG00000005174; Expressed in oocyte and 103 other tissues.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0080048; F:GDP-D-glucose phosphorylase activity; ISS:UniProtKB.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
DR   GO; GO:0016779; F:nucleotidyltransferase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006006; P:glucose metabolic process; ISS:UniProtKB.
DR   InterPro; IPR026506; GDPGP.
DR   PANTHER; PTHR20884; PTHR20884; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Guanine-nucleotide releasing factor; Hydrolase;
KW   Nucleotide-binding; Nucleotidyltransferase; Reference proteome;
KW   Transferase.
FT   CHAIN           1..385
FT                   /note="GDP-D-glucose phosphorylase 1"
FT                   /id="PRO_0000336749"
FT   ACT_SITE        218
FT                   /note="Tele-GMP-histidine intermediate"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   385 AA;  42333 MW;  86149682324C8D7D CRC64;
     MAIPHASNET SYLLPPNKED WEGQGIPDFV YEQEELMMEG VQWPRGALSL LNTPPLSHFD
     SALCSAWRQR MELGLFRYPL GELPTQTLPG TVGFVAQLNV ERGVQRRCPQ NIKSVRQEFD
     PEQFNFNQIR PGEVLFRLHR KQDCSGTVQQ EDILVVINVS PLEWGHVLLV PEPARGLPQR
     LLPGALRAGV EAVLLSSHPG FRVGFNSLGG LASVNHLHLH GYYLAHRLPV EGAPSEPLDP
     RGRLHVLQAL PAPGFLFYTS RPGPDLEALI SRVCRATDYL TDCEIAHNLF VTRGAPPGKA
     TSSSALSGVR VILWPRKPSF GIKEGEAFNV ALCELAGHLP VKTAQDFSSL TEAAALALIR
     ECLLPPAQAE DVRAALVALI AREEE