ID   GDPP1_DANRE             Reviewed;         343 AA.
AC   Q08CA1;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   31-OCT-2006, sequence version 1.
DT   03-AUG-2022, entry version 64.
DE   RecName: Full=GDP-D-glucose phosphorylase 1;
DE            EC=2.7.7.78;
GN   Name=gdpgp1; ORFNames=zgc:153343;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Ovary;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Specific and highly efficient GDP-D-glucose phosphorylase
CC       regulating the levels of GDP-D-glucose in cells. {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=GDP-alpha-D-glucose + phosphate = alpha-D-glucose 1-phosphate
CC         + GDP + H(+); Xref=Rhea:RHEA:30387, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:58189, ChEBI:CHEBI:58601,
CC         ChEBI:CHEBI:62230; EC=2.7.7.78;
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- MISCELLANEOUS: The orthologs in A.thaliana are GDP-L-galactose
CC       phosphorylases catalyzing the first reaction of the Smirnoff-Wheeler
CC       pathway, the major route to ascorbate biosynthesis in plants.
CC   -!- SIMILARITY: Belongs to the GDPGP1 family. {ECO:0000305}.
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DR   EMBL; BC124322; AAI24323.1; -; mRNA.
DR   RefSeq; NP_001071021.1; NM_001077553.1.
DR   AlphaFoldDB; Q08CA1; -.
DR   STRING; 7955.ENSDARP00000128968; -.
DR   PRIDE; Q08CA1; -.
DR   GeneID; 560896; -.
DR   KEGG; dre:560896; -.
DR   CTD; 390637; -.
DR   ZFIN; ZDB-GENE-060929-280; gdpgp1.
DR   eggNOG; KOG2720; Eukaryota.
DR   InParanoid; Q08CA1; -.
DR   OrthoDB; 1178383at2759; -.
DR   PhylomeDB; Q08CA1; -.
DR   PRO; PR:Q08CA1; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0080048; F:GDP-D-glucose phosphorylase activity; ISS:UniProtKB.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
DR   GO; GO:0016779; F:nucleotidyltransferase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006006; P:glucose metabolic process; ISS:UniProtKB.
DR   InterPro; IPR026506; GDPGP.
DR   PANTHER; PTHR20884; PTHR20884; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Guanine-nucleotide releasing factor; Hydrolase;
KW   Nucleotide-binding; Nucleotidyltransferase; Reference proteome;
KW   Transferase.
FT   CHAIN           1..343
FT                   /note="GDP-D-glucose phosphorylase 1"
FT                   /id="PRO_0000336753"
FT   ACT_SITE        183
FT                   /note="Tele-GMP-histidine intermediate"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   343 AA;  38992 MW;  2CD70DACD9A68129 CRC64;
     MGDCSIFTYT DNDFIGKVCC SGQQNRGRSR FDIALRSGWT EKRNTGLFRY RLDELETRIL
     PGSRGYIAQL NIMRGTERRK PQEILSVRQN FDPKQFNFNK INPKELLFEL KRESERKCSV
     IINVSPLEFG HCLLVPEPEK CFPQVLTHLA VQTGIETVLL SADPGFRVGF NSLGGFASVN
     HLHLHGYYLN HRLKIESSPA KLVLPNLNLY ELVDFPSGFL FYTQGPNLDL VVKAICSLTD
     VLVDHNIAHN LFLTRGCPPQ MEPDTSSSRN GVRVIVWPRL SCFGAKEESA FNVALCELAG
     HLPFKNRQDY ESATEETVQD IIQKYLLPQE ETAQLKEHLM KCL