ID   GDPP1_MACFA             Reviewed;         385 AA.
AC   Q8HXE4;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   03-AUG-2022, entry version 51.
DE   RecName: Full=GDP-D-glucose phosphorylase 1;
DE            EC=2.7.7.78;
GN   Name=GDPGP1; ORFNames=QflA-20034;
OS   Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Frontal cortex;
RG   International consortium for macaque cDNA sequencing and analysis;
RT   "DNA sequences of macaque genes expressed in brain or testis and its
RT   evolutionary implications.";
RL   Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Specific and highly efficient GDP-D-glucose phosphorylase
CC       regulating the levels of GDP-D-glucose in cells. {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=GDP-alpha-D-glucose + phosphate = alpha-D-glucose 1-phosphate
CC         + GDP + H(+); Xref=Rhea:RHEA:30387, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:58189, ChEBI:CHEBI:58601,
CC         ChEBI:CHEBI:62230; EC=2.7.7.78;
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the GDPGP1 family. {ECO:0000305}.
CC   -!- CAUTION: The orthologs in A.thaliana catalyze the first reaction of the
CC       Smirnoff-Wheeler pathway, the major route to ascorbate biosynthesis in
CC       plants. {ECO:0000305}.
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DR   EMBL; AB093646; BAC21620.1; -; mRNA.
DR   RefSeq; NP_001306358.1; NM_001319429.1.
DR   AlphaFoldDB; Q8HXE4; -.
DR   STRING; 9541.XP_005560569.1; -.
DR   GeneID; 102121174; -.
DR   CTD; 390637; -.
DR   eggNOG; KOG2720; Eukaryota.
DR   Proteomes; UP000233100; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0080048; F:GDP-D-glucose phosphorylase activity; ISS:UniProtKB.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
DR   GO; GO:0016779; F:nucleotidyltransferase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006006; P:glucose metabolic process; ISS:UniProtKB.
DR   InterPro; IPR026506; GDPGP.
DR   PANTHER; PTHR20884; PTHR20884; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Guanine-nucleotide releasing factor; Hydrolase;
KW   Nucleotide-binding; Nucleotidyltransferase; Reference proteome;
KW   Transferase.
FT   CHAIN           1..385
FT                   /note="GDP-D-glucose phosphorylase 1"
FT                   /id="PRO_0000336751"
FT   ACT_SITE        218
FT                   /note="Tele-GMP-histidine intermediate"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   385 AA;  42444 MW;  A83701F59EAA6898 CRC64;
     MALPHDSNET SYLLPPNNED WDRQAIPDFV YGQKDLMAEG IQWPRNAPGV LEALPQSPFD
     AALCSAWKQR VELGLFRYRL RELQTQILPG VVGFVAQLNV ERGVQRRRPQ TIKSVRQAFD
     PEQFNFNKIQ PGEVLYRLHR EPDLPGTLLQ EDILVVINVS PLEWGHVLLV PEPARGLPQR
     LLPGALRAGI EAVLLSLHPG FRVGFNSLGG LASVNHLHLH GYYLAHRLPV EQAPSEPLDP
     GGHLHLLQGL PAPGFLFYTR GPGLDLESLI CRVCRATDYL TDHEIAHNLF VTRGAPPGKT
     SPSSALTGVR VILWARKSCF GIKDGEAFNV ALCELAGHLP VKTSQDFSSL TEAAAVALIQ
     DCRLPPSQAE EVQAALVALM SQKEQ