GDPP1_MOUSE
ID GDPP1_MOUSE Reviewed; 386 AA.
AC Q3TLS3; Q3UP89; Q8C3L2; Q8C3Y3; Q8CI49;
DT 20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT 20-MAY-2008, sequence version 2.
DT 03-AUG-2022, entry version 95.
DE RecName: Full=GDP-D-glucose phosphorylase 1;
DE EC=2.7.7.78;
GN Name=Gdpgp1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Heart, Kidney, Mammary gland, and Spleen;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Spleen;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [4]
RP TISSUE SPECIFICITY.
RX PubMed=21507950; DOI=10.1074/jbc.m111.238774;
RA Adler L.N., Gomez T.A., Clarke S.G., Linster C.L.;
RT "A novel GDP-D-glucose phosphorylase involved in quality control of the
RT nucleoside diphosphate sugar pool in Caenorhabditis elegans and mammals.";
RL J. Biol. Chem. 286:21511-21523(2011).
CC -!- FUNCTION: Specific and highly efficient GDP-D-glucose phosphorylase
CC regulating the levels of GDP-D-glucose in cells. {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=GDP-alpha-D-glucose + phosphate = alpha-D-glucose 1-phosphate
CC + GDP + H(+); Xref=Rhea:RHEA:30387, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:58189, ChEBI:CHEBI:58601,
CC ChEBI:CHEBI:62230; EC=2.7.7.78;
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Highly expressed in the nervous and male
CC reproductive systems compared to kidney, liver and heart.
CC {ECO:0000269|PubMed:21507950}.
CC -!- MISCELLANEOUS: The orthologs in A.thaliana are GDP-L-galactose
CC phosphorylases catalyzing the first reaction of the Smirnoff-Wheeler
CC pathway, the major route to ascorbate biosynthesis in plants.
CC -!- SIMILARITY: Belongs to the GDPGP1 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC39476.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AK084531; BAC39213.1; -; mRNA.
DR EMBL; AK085577; BAC39476.1; ALT_FRAME; mRNA.
DR EMBL; AK143704; BAE25508.1; -; mRNA.
DR EMBL; AK166345; BAE38719.1; -; mRNA.
DR EMBL; BC037479; AAH37479.1; -; mRNA.
DR CCDS; CCDS39995.1; -.
DR RefSeq; NP_848867.2; NM_178752.3.
DR AlphaFoldDB; Q3TLS3; -.
DR BioGRID; 234734; 1.
DR STRING; 10090.ENSMUSP00000061808; -.
DR PhosphoSitePlus; Q3TLS3; -.
DR EPD; Q3TLS3; -.
DR MaxQB; Q3TLS3; -.
DR PaxDb; Q3TLS3; -.
DR PeptideAtlas; Q3TLS3; -.
DR PRIDE; Q3TLS3; -.
DR ProteomicsDB; 266789; -.
DR Ensembl; ENSMUST00000062915; ENSMUSP00000061808; ENSMUSG00000050973.
DR GeneID; 269952; -.
DR KEGG; mmu:269952; -.
DR UCSC; uc009hzu.1; mouse.
DR CTD; 390637; -.
DR MGI; MGI:2443429; Gdpgp1.
DR VEuPathDB; HostDB:ENSMUSG00000050973; -.
DR eggNOG; KOG2720; Eukaryota.
DR GeneTree; ENSGT00390000016718; -.
DR HOGENOM; CLU_041964_2_1_1; -.
DR InParanoid; Q3TLS3; -.
DR OMA; GIRVILW; -.
DR OrthoDB; 1178383at2759; -.
DR PhylomeDB; Q3TLS3; -.
DR TreeFam; TF313615; -.
DR BRENDA; 2.7.7.78; 3474.
DR BioGRID-ORCS; 269952; 0 hits in 72 CRISPR screens.
DR ChiTaRS; Gdpgp1; mouse.
DR PRO; PR:Q3TLS3; -.
DR Proteomes; UP000000589; Chromosome 7.
DR RNAct; Q3TLS3; protein.
DR Bgee; ENSMUSG00000050973; Expressed in primary oocyte and 130 other tissues.
DR Genevisible; Q3TLS3; MM.
DR GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR GO; GO:0080048; F:GDP-D-glucose phosphorylase activity; ISS:UniProtKB.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
DR GO; GO:0016779; F:nucleotidyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0006006; P:glucose metabolic process; ISS:UniProtKB.
DR InterPro; IPR026506; GDPGP.
DR PANTHER; PTHR20884; PTHR20884; 1.
PE 1: Evidence at protein level;
KW Cytoplasm; Guanine-nucleotide releasing factor; Hydrolase;
KW Nucleotide-binding; Nucleotidyltransferase; Reference proteome;
KW Transferase.
FT CHAIN 1..386
FT /note="GDP-D-glucose phosphorylase 1"
FT /id="PRO_0000336752"
FT ACT_SITE 219
FT /note="Tele-GMP-histidine intermediate"
FT /evidence="ECO:0000250"
FT CONFLICT 7
FT /note="L -> S (in Ref. 1; BAE38719 and 2; AAH37479)"
FT /evidence="ECO:0000305"
FT CONFLICT 8
FT /note="Q -> L (in Ref. 2; AAH37479)"
FT /evidence="ECO:0000305"
FT CONFLICT 44
FT /note="P -> S (in Ref. 1; BAE25508)"
FT /evidence="ECO:0000305"
FT CONFLICT 81
FT /note="E -> K (in Ref. 1; BAC39476)"
FT /evidence="ECO:0000305"
FT CONFLICT 95
FT /note="V -> L (in Ref. 1; BAC39476)"
FT /evidence="ECO:0000305"
FT CONFLICT 101
FT /note="E -> D (in Ref. 2; AAH37479)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 386 AA; 42515 MW; B69E1EECF9D719A0 CRC64;
MAVPHHLQET SYLLPPDPED WEKQGIPDFV YGQEDLVGKE VQWPRDSPSA VDTVPLSRFD
SALRSAWRQR LELGLFRYRL EDLQTQILPG SVGFVAQLNI ERGIQRRRPQ NIRSVRQEFD
PEQFNFNKIR PGEVLFRMQR EPKGPATPKQ EDDVLVVINV SPLEWGHVLL VPAPAQGLPQ
RLLPGVLRVG LEAVLLSLHP GFRVGFNSLG GLASVNHLHL HCYYLAHPLP VEGAPSTPLD
PKGCIHLLQA LPAPGFLFYT SGPGPDLEVL ISRVCRATDY LSDREIAHNL FVTRGAPPGP
TSSTSDLSGI RVILWARKSS FGIKESGAFN VALCELAGHL PVKTSQDFSS LTEAAAVALI
QDCLLPETQA GEVRAALVAL MAQEEL
